NPIDB: 1K4T structure

General information

PDB ID

1K4T

Title

HUMAN DNA TOPOISOMERASE I (70 KDA) IN COMPLEX WITH THE POISON TOPOTECAN AND COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX

PDB header

ISOMERASE/DNA

Date

2001-10-08

Experimental method

X-RAY DIFFRACTION

Resolution (A)

2.1

Kind

dna

Organism

HOMO SAPIENS


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PDB	PDBe	MMDB	Jena	OCA
CATH	PDBsum	HSSP	PDBePISA	UniProt
ProteopediA	BIPA
		PDIdb

Composition of PDB entry and biounits
File:	Protein chains:	DNA chains:	RNA chains:	No. of models:	Action:

PDB entry:

pdb1k4t.pdb	A	BCD		0

Biounits:

1k4t.pdb1.pdb	A	BCD		1

Pfam domains
Name:	Type:	Domain:	E-value:	Significance:	Clan:	Prot. chain:	Start res.:	End res.:	Nuc. chains:	Int. mode:	Action:

Topoisom_I	Domain	P11387_432-665	8.5e-103	1	CL0382	A	432	665	BD	H-Bb H-Mn L-Bb L-Mj
Topoisom_I_N	Family	P11387_215-429	1.4e-101	1	No_clan	A	215	429	BCD	H-Bb S-Bb S-Mj L-Bb L-Mn
Topo_C_assoc	Family	P11387_695-765	5.2e-31	1	No_clan	A	695	765	CB	H-Bb

SCOP domains
Classification:	Protein:	Prot. chain:	Start res.:	End res.:	Nuc. chains:	Int. mode:	Action:

Class: All alpha proteins Fold: Long alpha-hairpin Superfamily: Eukaryotic DNA topoisomerase I, dispensable insert domain Family: Eukaryotic DNA topoisomerase I, dispensable insert domain	Eukaryotic DNA topoisomerase I, dispensable insert domain	A	641	712		-
Class: Alpha and beta proteins (a+b) Fold: DNA breaking-rejoining enzymes Superfamily: DNA breaking-rejoining enzymes Family: Eukaryotic DNA topoisomerase I, catalytic core	Eukaryotic DNA topoisomerase I, catalytic core	A	431	640	CB	H-Bb H-Mn L-Bb
Class: Alpha and beta proteins (a+b) Fold: DNA breaking-rejoining enzymes Superfamily: DNA breaking-rejoining enzymes Family: Eukaryotic DNA topoisomerase I, catalytic core	Eukaryotic DNA topoisomerase I, catalytic core	A	431	640	BD	H-Bb H-Mn L-Bb
Class: Alpha and beta proteins (a+b) Fold: DNA breaking-rejoining enzymes Superfamily: DNA breaking-rejoining enzymes Family: Eukaryotic DNA topoisomerase I, catalytic core	Eukaryotic DNA topoisomerase I, catalytic core	A	713	765	CB	H-Bb
Class: Alpha and beta proteins (a+b) Fold: DNA breaking-rejoining enzymes Superfamily: DNA breaking-rejoining enzymes Family: Eukaryotic DNA topoisomerase I, catalytic core	Eukaryotic DNA topoisomerase I, catalytic core	A	713	765	BD	H-Bb
Class: Multi-domain proteins (alpha and beta) Fold: Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment Superfamily: Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment Family: Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	A	201	430	BCD	H-Bb S-Bb S-Mj L-Bb

GO terms
Protein chains:	GO type:	GO description:
A=174-765	C	cytoplasmic mRNA processing body
A=174-765	C	replication fork protection complex
A=174-765	C	perikaryon
A=174-765	C	nucleolus
A=174-765	C	nucleoplasm
A=174-765	F	ATP binding
A=174-765	F	DNA topoisomerase type I activity
A=174-765	F	chromatin binding
A=174-765	F	DNA topoisomerase (ATP-hydrolyzing) activity
A=174-765	P	chromatin remodeling
A=174-765	P	embryonic cleavage
A=174-765	P	DNA topological change
A=174-765	P	chromosome segregation
A=174-765	P	programmed cell death
A=174-765	P	phosphorylation
A=174-765	P	response to drug
A=174-765	P	DNA replication
A=174-765	P	virus-host interaction

Sequences

Download file with secondary structure created by Stride

1k4t.pdb1.pdb: [ download sequences in FASTA format ]

B (dna):

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C (dna):

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D (dna):

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A (protein):

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