General information
PDB ID 1O4X
Title TERNARY COMPLEX OF THE DNA BINDING DOMAINS OF THE OCT1 AND SOX2 TRANSCRIPTION FACTORS WITH A 19MER OLIGONUCLEOTIDE FROM THE HOXB1 REGULATORY ELEMENT
PDB header TRANSCRIPTION/DNA
Date 2003-07-17
Experimental method SOLUTION NMR
Resolution (A) N/A
Kind dna
Organism HOMO SAPIENS
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CATH PDBsum HSSP PDBePISA UniProt
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Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb1o4x.pdb AB CD 0
Pfam domains
Name: Type: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Action:
Pou Domain 3.3e-38 1 CL0123 A 8 79 CD
Homeobox Domain 2.3e-16 1 CL0123 A 79 161 CD
HMG_box Domain 4.9e-29 1 CL0114 B 208 276 CD
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: All alpha proteins
  Fold: DNA/RNA-binding 3-helical bundle
    Superfamily: Homeodomain-like
      Family: Homeodomain
Oct-1 POU Homeodomain A 110 163 CD  H-Bb H-Mj 
Class: All alpha proteins
  Fold: lambda repressor-like DNA-binding domains
    Superfamily: lambda repressor-like DNA-binding domains
      Family: POU-specific domain
Oct-1 A 5 79 CD  H-Bb H-Mj L-Bb 
Class: All alpha proteins
  Fold: HMG-box
    Superfamily: HMG-box
      Family: HMG-box
Sox-2 B N/A N/A CD  H-Bb H-Mn L-Bb L-Mn 
GO terms
Protein chains: GO type: GO description:
A=280-442 C transcription factor complex
A=280-442 C nucleoplasm
A=280-442 F sequence-specific DNA binding transcription factor activity
A=280-442 F sequence-specific DNA binding
A=280-442 P lens induction in camera-type eye
A=280-442 P positive regulation of transcription from RNA polymerase II promoter
A=280-442 P transcription from RNA polymerase III promoter
A=280-442 P negative regulation of transcription, DNA-dependent
A=280-442 P olfactory placode formation
B=39-121 C soluble fraction
B=39-121 C cytosol
B=39-121 F chromatin binding
B=39-121 F transcription regulatory region DNA binding
B=39-121 F miRNA binding
B=39-121 P cerebral cortex development
B=39-121 P response to retinoic acid
B=39-121 P lung alveolus development
B=39-121 P positive regulation of neuroblast proliferation
B=39-121 P retina morphogenesis in camera-type eye
B=39-121 P negative regulation of canonical Wnt receptor signaling pathway
B=39-121 P diencephalon morphogenesis
B=39-121 P eye development
B=39-121 P pituitary gland development
B=39-121 P negative regulation of neuron differentiation
B=39-121 P chromatin organization
B=39-121 P inner ear development
B=39-121 P forebrain neuron differentiation
B=39-121 P response to wounding
B=39-121 P negative regulation of epithelial cell proliferation
B=39-121 P negative regulation of osteoblast differentiation
B=39-121 P tongue development
B=39-121 P transcription, DNA-dependent
B=39-121 P male genitalia development
B=39-121 P negative regulation of transcription from RNA polymerase II promoter
B=39-121 P somatic stem cell maintenance
B=39-121 P neuron fate commitment
B=39-121 P positive regulation of Notch signaling pathway
B=39-121 P regulation of cysteine-type endopeptidase activity involved in apoptotic process
B=39-121 P detection of mechanical stimulus involved in sensory perception of sound
B=39-121 P positive regulation of epithelial cell differentiation
B=39-121 P pigment biosynthetic process
B=39-121 P response to growth factor stimulus
B=39-121 P inner ear morphogenesis
B=39-121 P cell cycle arrest
B=39-121 P detection of mechanical stimulus involved in equilibrioception
B=39-121 P neuronal stem cell maintenance
B=39-121 P adenohypophysis development
B=39-121 P positive regulation of neuron differentiation
B=39-121 P osteoblast differentiation
B=39-121 P epithelial tube branching involved in lung morphogenesis
B=39-121 P glial cell fate commitment
B=39-121 P positive regulation of MAPK cascade
B=39-121 P endodermal cell fate specification
Sequences
Download file with secondary structure created by Stride  
pdb1o4x.pdb:   [ download sequences in FASTA format ]
C (dna): 
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D (dna): 
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A (protein): 
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B (protein): 
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