General information
PDB ID 1A02
Title STRUCTURE OF THE DNA BINDING DOMAINS OF NFAT, FOS AND JUN BOUND TO DNA
PDB header TRANSCRIPTION/DNA
Date 1997-12-08
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.7
Kind dna
Organism HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb1a02.pdb NFJ AB 0
Biounits:
1a02.pdb1.pdb NFJ AB 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
RHD_dimer Domain Q13469_579-678 6.2e-26 1 CL0159 N 579 678   
RHD_DNA_bind Domain Q13469_410-570 4.5e-23 1 CL0073 N 410 570 AB  H-Bb S-Bb L-Bb L-Mj L-Mn 
bZIP_2 Family 0.00000007 1 CL0018 F 140 189 AB
bZIP_1 Family P05412_257-308 0.0000000000000035 1 CL0018 J 267 318 AB  H-Bb H-Mj 
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: All beta proteins
  Fold: Immunoglobulin-like beta-sandwich
    Superfamily: E set domains
      Family: NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain
T-cell transcription factor NFAT1 (NFATC2) N 577 678 -
Class: All beta proteins
  Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f
    Superfamily: p53-like transcription factors
      Family: Rel/Dorsal transcription factors, DNA-binding domain
T-cell transcription factor NFAT1 (NFATC), DNA-binding domain N 399 576 AB  H-Bb H-Mj S-Bb L-Bb L-Mj L-Mn 
Class: Coiled coil proteins
  Fold: Parallel coiled-coil
    Superfamily: Leucine zipper domain
      Family: Leucine zipper domain
C-fos F N/A N/A AB  H-Bb H-Mj 
Class: Coiled coil proteins
  Fold: Parallel coiled-coil
    Superfamily: Leucine zipper domain
      Family: Leucine zipper domain
C-jun J N/A N/A AB  H-Bb H-Mj 
GO terms
Protein chains: GO type: GO description:
F=139-193 C nucleoplasm
F=139-193 F sequence-specific DNA binding transcription factor activity
F=139-193 F sequence-specific DNA binding
F=139-193 F transcription regulatory region DNA binding
F=139-193 P toll-like receptor 2 signaling pathway
F=139-193 P toll-like receptor 4 signaling pathway
F=139-193 P inflammatory response
F=139-193 P SMAD protein signal transduction
F=139-193 P TRIF-dependent toll-like receptor signaling pathway
F=139-193 P DNA methylation
F=139-193 P MyD88-dependent toll-like receptor signaling pathway
F=139-193 P cellular response to reactive oxygen species
F=139-193 P transcription from RNA polymerase II promoter
F=139-193 P stress-activated MAPK cascade
F=139-193 P transforming growth factor beta receptor signaling pathway
F=139-193 P regulation of transcription from RNA polymerase II promoter
F=139-193 P regulation of sequence-specific DNA binding transcription factor activity
F=139-193 P positive regulation of transcription, DNA-dependent
F=139-193 P innate immune response
F=139-193 P toll-like receptor 3 signaling pathway
F=139-193 P toll-like receptor 1 signaling pathway
F=139-193 P Toll signaling pathway
J=254-308 C nuclear euchromatin
J=254-308 C transcription factor complex
J=254-308 C transcriptional repressor complex
J=254-308 F RNA polymerase II distal enhancer sequence-specific DNA binding
J=254-308 F double-stranded DNA binding
J=254-308 F RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
J=254-308 F RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
J=254-308 F cAMP response element binding
J=254-308 F transcription coactivator activity
J=254-308 F Rho GTPase activator activity
J=254-308 P axon regeneration
J=254-308 P aging
J=254-308 P regulation of cell cycle
J=254-308 P cellular response to potassium ion starvation
J=254-308 P negative regulation of DNA binding
J=254-308 P positive regulation of neuron apoptotic process
J=254-308 P monocyte differentiation
J=254-308 P SMAD protein import into nucleus
J=254-308 P angiogenesis
J=254-308 P response to mechanical stimulus
J=254-308 P positive regulation of DNA replication
J=254-308 P leading edge cell differentiation
J=254-308 P negative regulation by host of viral transcription
J=254-308 P negative regulation of transcription, DNA-dependent
J=254-308 P negative regulation of protein autophosphorylation
J=254-308 P liver development
J=254-308 P positive regulation of fibroblast proliferation
J=254-308 P negative regulation of cell proliferation
J=254-308 P response to cytokine stimulus
J=254-308 P membrane depolarization
J=254-308 P response to lipopolysaccharide
J=254-308 P positive regulation of smooth muscle cell proliferation
J=254-308 P response to cAMP
J=254-308 P positive regulation of monocyte differentiation
J=254-308 P negative regulation of neuron apoptotic process
J=254-308 P outflow tract morphogenesis
J=254-308 P positive regulation by host of viral transcription
J=254-308 P response to radiation
J=254-308 P circadian rhythm
J=254-308 P learning
J=254-308 P response to organic cyclic compound
J=254-308 P positive regulation of endothelial cell proliferation
J=254-308 P response to hydrogen peroxide
J=254-308 P microglial cell activation
J=254-308 P release of cytochrome c from mitochondria
J=254-308 P cellular response to calcium ion
N=396-678 C ribonucleoprotein complex
N=396-678 C cytosol
N=396-678 C nucleus
N=396-678 C plasma membrane
N=396-678 C actin cytoskeleton
N=396-678 F DNA binding
N=396-678 P B cell receptor signaling pathway
N=396-678 P cytokine production
N=396-678 P transcription, DNA-dependent
N=396-678 P positive regulation of B cell proliferation
N=396-678 P positive regulation of transcription from RNA polymerase II promoter
N=396-678 P response to drug
N=396-678 P response to DNA damage stimulus
Sequences
Download file with secondary structure created by Stride  
1a02.pdb1.pdb:   [ download sequences in FASTA format ]
A (dna): 
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B (dna): 
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F (protein): 
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J (protein): 
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N (protein): 
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