General information
PDB ID 1DE8
Title HUMAN APURINIC/APYRIMIDINIC ENDONUCLEASE-1 (APE1) BOUND TO ABASIC DNA
PDB header LYASE/DNA
Date 1999-11-13
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.95
Kind dna
Organism HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb1de8.pdb BA XYUV 0
Biounits:
1de8.pdb1.pdb A UV 1
1de8.pdb2.pdb B XY 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Exo_endo_phos Domain P27695_65-309 8.7e-22 1 CL0530 A 65 309 UV   
Exo_endo_phos Domain P27695_65-309 8.7e-22 1 CL0530 B 65 309 XY   
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: Alpha and beta proteins (a+b)
  Fold: DNase I-like
    Superfamily: DNase I-like
      Family: DNase I-like
DNA repair endonuclease Hap1 A N/A N/A UV -
Class: Alpha and beta proteins (a+b)
  Fold: DNase I-like
    Superfamily: DNase I-like
      Family: DNase I-like
DNA repair endonuclease Hap1 B N/A N/A XY -
GO terms
Protein chains: GO type: GO description:
A/B=43-318 C nucleolus
A/B=43-318 C endoplasmic reticulum
A/B=43-318 C mitochondrion
A/B=43-318 C perinuclear region of cytoplasm
A/B=43-318 C nuclear speck
A/B=43-318 C ribosome
A/B=43-318 C centrosome
A/B=43-318 F metal ion binding
A/B=43-318 F 3'-5' exonuclease activity
A/B=43-318 F oxidoreductase activity
A/B=43-318 F ribonuclease H activity
A/B=43-318 F site-specific endodeoxyribonuclease activity, specific for altered base
A/B=43-318 F transcription corepressor activity
A/B=43-318 F uracil DNA N-glycosylase activity
A/B=43-318 F RNA binding
A/B=43-318 F damaged DNA binding
A/B=43-318 F DNA-(apurinic or apyrimidinic site) lyase activity
A/B=43-318 F transcription coactivator activity
A/B=43-318 F chromatin DNA binding
A/B=43-318 F phosphodiesterase I activity
A/B=43-318 P positive regulation of anti-apoptosis
A/B=43-318 P regulation of transcription, DNA-dependent
A/B=43-318 P DNA demethylation
A/B=43-318 P transcription, DNA-dependent
A/B=43-318 P base-excision repair
A/B=43-318 P DNA recombination
A/B=43-318 P regulation of mRNA stability
A/B=43-318 P positive regulation of DNA repair
Sequences
Download file with secondary structure created by Stride  
1de8.pdb1.pdb:   [ download sequences in FASTA format ]
U (dna): 
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V (dna): 
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A (protein): 
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1de8.pdb2.pdb:   [ download sequences in FASTA format ]
X (dna): 
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Y (dna): 
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B (protein): 
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