General information
PDB ID 1EJ9
Title CRYSTAL STRUCTURE OF HUMAN TOPOISOMERASE I DNA COMPLEX
PDB header ISOMERASE/DNA
Date 2000-03-01
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.6
Kind dna
Organism HOMO SAPIENS
Download
complex
View in
Jmol
Quick Links
PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb1ej9.pdb A CD 0
Biounits:
1ej9.pdb1.pdb A CD 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Topoisom_I Domain P11387_432-635 1e-94 1 CL0382 A 432 724 CD  H-Bb H-Mn L-Bb L-Mj 
Topoisom_I_N Family P11387_215-429 9.6e-102 1 No_clan A 215 429 CD  S-Bb S-Mj L-Bb L-Mj L-Mn 
Topo_C_assoc Family P11387_713-765 1.8e-27 1 No_clan A 628 765 CD  H-Bb H-Mj L-Bb 
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: Alpha and beta proteins (a+b)
  Fold: DNA breaking-rejoining enzymes
    Superfamily: DNA breaking-rejoining enzymes
      Family: Eukaryotic DNA topoisomerase I, catalytic core
Eukaryotic DNA topoisomerase I, catalytic core A 431 633 DC  H-Bb H-Mn L-Bb 
Class: Alpha and beta proteins (a+b)
  Fold: DNA breaking-rejoining enzymes
    Superfamily: DNA breaking-rejoining enzymes
      Family: Eukaryotic DNA topoisomerase I, catalytic core
Eukaryotic DNA topoisomerase I, catalytic core A 714 765 DC  H-Bb H-Mj L-Bb 
Class: Alpha and beta proteins (a+b)
  Fold: DNA breaking-rejoining enzymes
    Superfamily: DNA breaking-rejoining enzymes
      Family: Eukaryotic DNA topoisomerase I, catalytic core
Eukaryotic DNA topoisomerase I, catalytic core A 431 633 CD  H-Bb H-Mn L-Bb 
Class: Alpha and beta proteins (a+b)
  Fold: DNA breaking-rejoining enzymes
    Superfamily: DNA breaking-rejoining enzymes
      Family: Eukaryotic DNA topoisomerase I, catalytic core
Eukaryotic DNA topoisomerase I, catalytic core A 714 765 CD  H-Bb H-Mj L-Bb 
Class: Multi-domain proteins (alpha and beta)
  Fold: Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment
    Superfamily: Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment
      Family: Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment A 203 430 CD  S-Bb S-Mj L-Bb L-Mj L-Mn 
GO terms
Protein chains: GO type: GO description:
A=203-765 C nucleolus
A=203-765 C nucleoplasm
A=203-765 C replication fork protection complex
A=203-765 C perikaryon
A=203-765 C cytoplasmic mRNA processing body
A=203-765 F DNA topoisomerase (ATP-hydrolyzing) activity
A=203-765 F chromatin binding
A=203-765 F DNA topoisomerase type I activity
A=203-765 F ATP binding
A=203-765 P DNA replication
A=203-765 P virus-host interaction
A=203-765 P chromatin remodeling
A=203-765 P response to drug
A=203-765 P embryonic cleavage
A=203-765 P DNA topological change
A=203-765 P phosphorylation
A=203-765 P chromosome segregation
A=203-765 P programmed cell death
Sequences
Download file with secondary structure created by Stride  
1ej9.pdb1.pdb:   [ download sequences in FASTA format ]
C (dna): 
Click "SHOW" for view sequence
D (dna): 
Click "SHOW" for view sequence
A (protein): 
Click "SHOW" for view sequence
© NPIDB team 2003 - 2019

text