General information
PDB ID 1FOS
Title TWO HUMAN C-FOS:C-JUN:DNA COMPLEXES
PDB header TRANSCRIPTION/DNA
Date 1995-03-07
Experimental method X-RAY DIFFRACTION
Resolution (A) 3.05
Kind dna
Organism HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb1fos.pdb EFGH ABCD 0
Biounits:
1fos.pdb1.pdb EF AB 1
1fos.pdb2.pdb GH CD 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
bZIP_1 Coiled-coil P01100_139-197 1.3e-09 1 CL0018 E 139 197 AB  H-Bb H-Mj 
bZIP_1 Coiled-coil P05412_257-313 4.6e-17 1 CL0018 F 266 322 BA  H-Bb H-Mj 
ZapB Coiled-coil P05412_265-310 0.0005 0 CL0225 F 276 321 BA  H-Mj 
bZIP_1 Coiled-coil P01100_139-197 3.5e-09 1 CL0018 G 140 197 CD  H-Bb H-Mj 
bZIP_1 Coiled-coil P05412_257-313 1.8e-17 1 CL0018 H 265 322 CD  H-Bb H-Mj 
ZapB Coiled-coil P05412_265-310 0.00048 0 CL0225 H 277 321 CD  H-Bb H-Mj 
PspA_IM30 Family P05412_268-311 0.00051 0 CL0235 F 279 322 B  H-Mj 
PspA_IM30 Family P05412_268-311 0.00057 0 CL0235 H 279 322 CD  H-Bb H-Mj 
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: Coiled coil proteins
  Fold: Parallel coiled-coil
    Superfamily: Leucine zipper domain
      Family: Leucine zipper domain
C-jun F N/A N/A BA  H-Bb H-Mj 
Class: Coiled coil proteins
  Fold: Parallel coiled-coil
    Superfamily: Leucine zipper domain
      Family: Leucine zipper domain
C-fos E N/A N/A AB  H-Bb H-Mj 
Class: Coiled coil proteins
  Fold: Parallel coiled-coil
    Superfamily: Leucine zipper domain
      Family: Leucine zipper domain
C-jun H N/A N/A CD  H-Bb H-Mj 
Class: Coiled coil proteins
  Fold: Parallel coiled-coil
    Superfamily: Leucine zipper domain
      Family: Leucine zipper domain
C-fos G N/A N/A CD  H-Bb H-Mj 
GO terms
Protein chains: GO type: GO description:
E/G=139-200 C cytosol
E/G=139-200 C endoplasmic reticulum
E/G=139-200 C membrane
E/G=139-200 C neuron projection
E/G=139-200 C nuclear chromatin
E/G=139-200 C nucleoplasm
E/G=139-200 C nucleus
E/G=139-200 C protein-DNA complex
E/G=139-200 C transcription factor AP-1 complex
E/G=139-200 F chromatin binding
E/G=139-200 F DNA-binding transcription activator activity, RNA polymerase II-specific
E/G=139-200 F DNA-binding transcription factor activity
E/G=139-200 F DNA-binding transcription factor activity, RNA polymerase II-specific
E/G=139-200 F protein-containing complex binding
E/G=139-200 F R-SMAD binding
E/G=139-200 F RNA polymerase II activating transcription factor binding
E/G=139-200 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
E/G=139-200 F RNA polymerase II core promoter sequence-specific DNA binding
E/G=139-200 F sequence-specific double-stranded DNA binding
E/G=139-200 F transcription factor binding
E/G=139-200 F transcription regulatory region sequence-specific DNA binding
E/G=139-200 P aging
E/G=139-200 P cellular response to cadmium ion
E/G=139-200 P cellular response to calcium ion
E/G=139-200 P cellular response to extracellular stimulus
E/G=139-200 P cellular response to hormone stimulus
E/G=139-200 P cellular response to reactive oxygen species
E/G=139-200 P conditioned taste aversion
E/G=139-200 P cytokine-mediated signaling pathway
E/G=139-200 P DNA methylation
E/G=139-200 P Fc-epsilon receptor signaling pathway
E/G=139-200 P female pregnancy
E/G=139-200 P inflammatory response
E/G=139-200 P nervous system development
E/G=139-200 P positive regulation of neuron death
E/G=139-200 P positive regulation of osteoclast differentiation
E/G=139-200 P positive regulation of pri-miRNA transcription by RNA polymerase II
E/G=139-200 P positive regulation of transcription by RNA polymerase II
E/G=139-200 P positive regulation of transcription, DNA-templated
E/G=139-200 P regulation of DNA-binding transcription factor activity
E/G=139-200 P regulation of transcription by RNA polymerase II
E/G=139-200 P response to cAMP
E/G=139-200 P response to cold
E/G=139-200 P response to corticosterone
E/G=139-200 P response to drug
E/G=139-200 P response to gravity
E/G=139-200 P response to immobilization stress
E/G=139-200 P response to light stimulus
E/G=139-200 P response to lipopolysaccharide
E/G=139-200 P response to muscle stretch
E/G=139-200 P response to progesterone
E/G=139-200 P response to toxic substance
E/G=139-200 P skeletal muscle cell differentiation
E/G=139-200 P sleep
E/G=139-200 P SMAD protein signal transduction
E/G=139-200 P transcription by RNA polymerase II
E/G=139-200 P transforming growth factor beta receptor signaling pathway
F/H=254-315 C cytosol
F/H=254-315 C nuclear chromatin
F/H=254-315 C nuclear chromosome
F/H=254-315 C nuclear euchromatin
F/H=254-315 C nucleoplasm
F/H=254-315 C nucleus
F/H=254-315 C transcription factor AP-1 complex
F/H=254-315 C transcription regulator complex
F/H=254-315 C transcription repressor complex
F/H=254-315 F cAMP response element binding
F/H=254-315 F chromatin binding
F/H=254-315 F DNA binding
F/H=254-315 F DNA-binding transcription activator activity, RNA polymerase II-specific
F/H=254-315 F DNA-binding transcription factor activity
F/H=254-315 F DNA-binding transcription factor activity, RNA polymerase II-specific
F/H=254-315 F DNA-binding transcription repressor activity, RNA polymerase II-specific
F/H=254-315 F enzyme binding
F/H=254-315 F GTPase activator activity
F/H=254-315 F HMG box domain binding
F/H=254-315 F identical protein binding
F/H=254-315 F protein-containing complex binding
F/H=254-315 F R-SMAD binding
F/H=254-315 F RNA binding
F/H=254-315 F RNA polymerase II activating transcription factor binding
F/H=254-315 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
F/H=254-315 F sequence-specific double-stranded DNA binding
F/H=254-315 F transcription coactivator activity
F/H=254-315 F transcription factor binding
F/H=254-315 F transcription regulatory region sequence-specific DNA binding
F/H=254-315 F ubiquitin protein ligase binding
F/H=254-315 F ubiquitin-like protein ligase binding
F/H=254-315 P aging
F/H=254-315 P angiogenesis
F/H=254-315 P axon regeneration
F/H=254-315 P cellular response to cadmium ion
F/H=254-315 P cellular response to calcium ion
F/H=254-315 P cellular response to hormone stimulus
F/H=254-315 P cellular response to potassium ion starvation
F/H=254-315 P cellular response to reactive oxygen species
F/H=254-315 P circadian rhythm
F/H=254-315 P eyelid development in camera-type eye
F/H=254-315 P Fc-epsilon receptor signaling pathway
F/H=254-315 P leading edge cell differentiation
F/H=254-315 P learning
F/H=254-315 P liver development
F/H=254-315 P membrane depolarization
F/H=254-315 P microglial cell activation
F/H=254-315 P monocyte differentiation
F/H=254-315 P negative regulation by host of viral transcription
F/H=254-315 P negative regulation of cell population proliferation
F/H=254-315 P negative regulation of DNA binding
F/H=254-315 P negative regulation of neuron apoptotic process
F/H=254-315 P negative regulation of protein autophosphorylation
F/H=254-315 P negative regulation of transcription by RNA polymerase II
F/H=254-315 P negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
F/H=254-315 P negative regulation of transcription, DNA-templated
F/H=254-315 P outflow tract morphogenesis
F/H=254-315 P positive regulation by host of viral transcription
F/H=254-315 P positive regulation of apoptotic process
F/H=254-315 P positive regulation of cell differentiation
F/H=254-315 P positive regulation of DNA replication
F/H=254-315 P positive regulation of DNA-templated transcription, initiation
F/H=254-315 P positive regulation of endothelial cell proliferation
F/H=254-315 P positive regulation of epithelial cell migration
F/H=254-315 P positive regulation of ERK1 and ERK2 cascade
F/H=254-315 P positive regulation of fibroblast proliferation
F/H=254-315 P positive regulation of monocyte differentiation
F/H=254-315 P positive regulation of neuron apoptotic process
F/H=254-315 P positive regulation of pri-miRNA transcription by RNA polymerase II
F/H=254-315 P positive regulation of transcription by RNA polymerase II
F/H=254-315 P positive regulation of transcription, DNA-templated
F/H=254-315 P positive regulation of vascular associated smooth muscle cell proliferation
F/H=254-315 P Ras protein signal transduction
F/H=254-315 P regulation of cell cycle
F/H=254-315 P regulation of cell population proliferation
F/H=254-315 P regulation of DNA-binding transcription factor activity
F/H=254-315 P release of cytochrome c from mitochondria
F/H=254-315 P response to cAMP
F/H=254-315 P response to cytokine
F/H=254-315 P response to drug
F/H=254-315 P response to hydrogen peroxide
F/H=254-315 P response to lipopolysaccharide
F/H=254-315 P response to mechanical stimulus
F/H=254-315 P response to muscle stretch
F/H=254-315 P response to organic substance
F/H=254-315 P response to radiation
F/H=254-315 P SMAD protein signal transduction
F/H=254-315 P transcription by RNA polymerase II
F/H=254-315 P transforming growth factor beta receptor signaling pathway
Sequences
Download file with secondary structure created by Stride  
1fos.pdb1.pdb:   [ download sequences in FASTA format ]
A (dna): 
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B (dna): 
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E (protein): 
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F (protein): 
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1fos.pdb2.pdb:   [ download sequences in FASTA format ]
C (dna): 
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D (dna): 
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G (protein): 
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H (protein): 
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