General information
PDB ID 1FOS
Title TWO HUMAN C-FOS:C-JUN:DNA COMPLEXES
PDB header TRANSCRIPTION/DNA
Date 1995-03-07
Experimental method X-RAY DIFFRACTION
Resolution (A) 3.05
Kind dna
Organism HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb1fos.pdb EFGH ABCD 0
Biounits:
1fos.pdb1.pdb EF AB 1
1fos.pdb2.pdb GH CD 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
bZIP_1 Family P01100_139-197 1.1e-09 1 CL0018 E 139 197 AB  H-Bb H-Mj 
bZIP_1 Family P05412_257-313 4e-17 1 CL0018 F 266 322 BA  H-Bb H-Mj 
ZapB Family 0.00035 0 No_clan F 276 321 BA
PspA_IM30 Family 0.00044 0 CL0235 F 279 322 B
bZIP_1 Family P01100_139-197 3.1e-09 1 CL0018 G 140 197 CD  H-Bb H-Mj 
bZIP_1 Family P05412_257-313 1.6e-17 1 CL0018 H 265 322 CD  H-Bb H-Mj 
ZapB Family 0.0004 0 No_clan H 277 321 CD
PspA_IM30 Family 0.0005 0 CL0235 H 279 322 CD
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: Coiled coil proteins
  Fold: Parallel coiled-coil
    Superfamily: Leucine zipper domain
      Family: Leucine zipper domain
C-jun F N/A N/A BA  H-Bb H-Mj 
Class: Coiled coil proteins
  Fold: Parallel coiled-coil
    Superfamily: Leucine zipper domain
      Family: Leucine zipper domain
C-fos E N/A N/A AB  H-Bb H-Mj 
Class: Coiled coil proteins
  Fold: Parallel coiled-coil
    Superfamily: Leucine zipper domain
      Family: Leucine zipper domain
C-jun H N/A N/A CD  H-Bb H-Mj 
Class: Coiled coil proteins
  Fold: Parallel coiled-coil
    Superfamily: Leucine zipper domain
      Family: Leucine zipper domain
C-fos G N/A N/A CD  H-Bb H-Mj 
GO terms
Protein chains: GO type: GO description:
E/G=139-200 C nucleoplasm
E/G=139-200 F sequence-specific DNA binding transcription factor activity
E/G=139-200 F transcription regulatory region DNA binding
E/G=139-200 F sequence-specific DNA binding
E/G=139-200 P Toll signaling pathway
E/G=139-200 P inflammatory response
E/G=139-200 P MyD88-dependent toll-like receptor signaling pathway
E/G=139-200 P innate immune response
E/G=139-200 P TRIF-dependent toll-like receptor signaling pathway
E/G=139-200 P cellular response to reactive oxygen species
E/G=139-200 P toll-like receptor 1 signaling pathway
E/G=139-200 P toll-like receptor 2 signaling pathway
E/G=139-200 P toll-like receptor 3 signaling pathway
E/G=139-200 P toll-like receptor 4 signaling pathway
E/G=139-200 P transcription from RNA polymerase II promoter
E/G=139-200 P SMAD protein signal transduction
E/G=139-200 P positive regulation of transcription, DNA-dependent
E/G=139-200 P transforming growth factor beta receptor signaling pathway
E/G=139-200 P regulation of sequence-specific DNA binding transcription factor activity
E/G=139-200 P regulation of transcription from RNA polymerase II promoter
E/G=139-200 P stress-activated MAPK cascade
E/G=139-200 P DNA methylation
F/H=254-315 C transcriptional repressor complex
F/H=254-315 C cytosol
F/H=254-315 C transcription factor complex
F/H=254-315 C nuclear euchromatin
F/H=254-315 F double-stranded DNA binding
F/H=254-315 F RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
F/H=254-315 F transcription coactivator activity
F/H=254-315 F RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
F/H=254-315 F Rho GTPase activator activity
F/H=254-315 F cAMP response element binding
F/H=254-315 F RNA polymerase II distal enhancer sequence-specific DNA binding
F/H=254-315 P response to mechanical stimulus
F/H=254-315 P liver development
F/H=254-315 P negative regulation of transcription, DNA-dependent
F/H=254-315 P regulation of cell cycle
F/H=254-315 P negative regulation of cell proliferation
F/H=254-315 P negative regulation of neuron apoptotic process
F/H=254-315 P negative regulation by host of viral transcription
F/H=254-315 P release of cytochrome c from mitochondria
F/H=254-315 P axon regeneration
F/H=254-315 P positive regulation of fibroblast proliferation
F/H=254-315 P response to organic cyclic compound
F/H=254-315 P leading edge cell differentiation
F/H=254-315 P circadian rhythm
F/H=254-315 P response to hydrogen peroxide
F/H=254-315 P outflow tract morphogenesis
F/H=254-315 P positive regulation of endothelial cell proliferation
F/H=254-315 P response to lipopolysaccharide
F/H=254-315 P response to radiation
F/H=254-315 P learning
F/H=254-315 P microglial cell activation
F/H=254-315 P membrane depolarization
F/H=254-315 P positive regulation of smooth muscle cell proliferation
F/H=254-315 P positive regulation of neuron apoptotic process
F/H=254-315 P positive regulation by host of viral transcription
F/H=254-315 P response to cAMP
F/H=254-315 P positive regulation of DNA replication
F/H=254-315 P negative regulation of protein autophosphorylation
F/H=254-315 P response to cytokine stimulus
F/H=254-315 P response to drug
F/H=254-315 P cellular response to potassium ion starvation
F/H=254-315 P angiogenesis
F/H=254-315 P cellular response to calcium ion
F/H=254-315 P aging
F/H=254-315 P negative regulation of DNA binding
F/H=254-315 P monocyte differentiation
F/H=254-315 P positive regulation of monocyte differentiation
F/H=254-315 P SMAD protein import into nucleus
Sequences
Download file with secondary structure created by Stride  
1fos.pdb1.pdb:   [ download sequences in FASTA format ]
A (dna): 
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B (dna): 
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E (protein): 
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F (protein): 
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1fos.pdb2.pdb:   [ download sequences in FASTA format ]
C (dna): 
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D (dna): 
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G (protein): 
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H (protein): 
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