General information
PDB ID 1HAO
Title COMPLEX OF HUMAN ALPHA-THROMBIN WITH A 15MER OLIGONUCLEOTIDE GGTTGGTGTGGTTGG (BASED ON NMR MODEL OF DNA)
PDB header HYDROLASE/HYDROLASE INHIBITOR/DNA
Date 1995-10-03
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.8
Kind dna
Organism HOMO SAPIENS
Download
complex
View in
Jmol
Quick Links
PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb1hao.pdb LH D 0
Biounits:
1hao.pdb1.pdb LH D 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Trypsin Domain P00734_364-613 4.4e-70 1 CL0124 H 16 238 D   
Thrombin_light Domain 0.0000000000000026 1 No_clan L 1 14
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: All beta proteins
  Fold: Trypsin-like serine proteases
    Superfamily: Trypsin-like serine proteases
      Family: Eukaryotic proteases
Thrombin H N/A N/A D -
Class: All beta proteins
  Fold: Trypsin-like serine proteases
    Superfamily: Trypsin-like serine proteases
      Family: Eukaryotic proteases
Thrombin L N/A N/A D -
Class: All beta proteins
  Fold: Trypsin-like serine proteases
    Superfamily: Trypsin-like serine proteases
      Family: Eukaryotic proteases
Thrombin H N/A N/A -
Class: All beta proteins
  Fold: Trypsin-like serine proteases
    Superfamily: Trypsin-like serine proteases
      Family: Eukaryotic proteases
Thrombin L N/A N/A -
GO terms
Protein chains: GO type: GO description:
H=364-622, L=328-363 C Golgi lumen
H=364-622, L=328-363 C extracellular space
H=364-622, L=328-363 C plasma membrane
H=364-622, L=328-363 C endoplasmic reticulum lumen
H=364-622, L=328-363 F calcium ion binding
H=364-622, L=328-363 F serine-type endopeptidase activity
H=364-622, L=328-363 F thrombospondin receptor activity
H=364-622, L=328-363 P peptidyl-glutamic acid carboxylation
H=364-622, L=328-363 P positive regulation of phosphatidylinositol 3-kinase cascade
H=364-622, L=328-363 P cytosolic calcium ion homeostasis
H=364-622, L=328-363 P positive regulation of cell proliferation
H=364-622, L=328-363 P cell surface receptor signaling pathway
H=364-622, L=328-363 P regulation of cell shape
H=364-622, L=328-363 P positive regulation of collagen biosynthetic process
H=364-622, L=328-363 P platelet activation
H=364-622, L=328-363 P positive regulation of protein phosphorylation
H=364-622, L=328-363 P acute-phase response
H=364-622, L=328-363 P positive regulation of cell growth
H=364-622, L=328-363 P negative regulation of astrocyte differentiation
H=364-622, L=328-363 P blood coagulation, intrinsic pathway
H=364-622, L=328-363 P negative regulation of proteolysis
H=364-622, L=328-363 P fibrinolysis
H=364-622, L=328-363 P positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
H=364-622, L=328-363 P proteolysis
H=364-622, L=328-363 P positive regulation of reactive oxygen species metabolic process
H=364-622, L=328-363 P leukocyte migration
H=364-622, L=328-363 P negative regulation of fibrinolysis
H=364-622, L=328-363 P post-translational protein modification
H=364-622, L=328-363 P negative regulation of platelet activation
H=364-622, L=328-363 P positive regulation of release of sequestered calcium ion into cytosol
Sequences
Download file with secondary structure created by Stride  
1hao.pdb1.pdb:   [ download sequences in FASTA format ]
D (dna): 
Click "SHOW" for view sequence
H (protein): 
Click "SHOW" for view sequence
L (protein): 
Click "SHOW" for view sequence
© NPIDB team 2003 - 2019

text