General information
PDB ID 1HBX
Title TERNARY COMPLEX OF SAP-1 AND SRF WITH SPECIFIC SRE DNA
PDB header GENE REGULATION
Date 2001-04-20
Experimental method X-RAY DIFFRACTION
Resolution (A) 3.15
Kind dna
Organism HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb1hbx.pdb ABDEGH CFWX 0
Biounits:
1hbx.pdb1.pdb ABG CW 1
1hbx.pdb2.pdb DEH FX 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
SRF-TF Domain P11831_150-197 4.9e-21 1 No_clan A 150 197 CW   
SRF-TF Domain P11831_150-197 4.7e-21 1 No_clan B 150 197 CW   
SRF-TF Domain P11831_150-197 4.7e-21 1 No_clan D 150 197 FX   
SRF-TF Domain P11831_150-197 5.2e-21 1 No_clan E 150 197 FX   
Ets Domain P28324_6-85 8.5e-37 1 CL0123 G 6 85 CW   
Ets Domain P28324_6-85 7.8e-37 1 CL0123 H 6 85 FX   
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: Alpha and beta proteins (a+b)
  Fold: SRF-like
    Superfamily: SRF-like
      Family: SRF-like
Serum response factor (SRF) core A N/A N/A CW  H-Bb L-Bb 
Class: Alpha and beta proteins (a+b)
  Fold: SRF-like
    Superfamily: SRF-like
      Family: SRF-like
Serum response factor (SRF) core B N/A N/A CW  H-Bb H-Mj L-Bb L-Mn 
Class: Alpha and beta proteins (a+b)
  Fold: SRF-like
    Superfamily: SRF-like
      Family: SRF-like
Serum response factor (SRF) core D N/A N/A FX  H-Bb 
Class: Alpha and beta proteins (a+b)
  Fold: SRF-like
    Superfamily: SRF-like
      Family: SRF-like
Serum response factor (SRF) core E N/A N/A FX  H-Bb H-Mj L-Bb L-Mn 
Class: All alpha proteins
  Fold: DNA/RNA-binding 3-helical bundle
    Superfamily: "Winged helix" DNA-binding domain
      Family: ets domain
Serum response factor accessory protein 1a, SAP-1 G N/A N/A CW  L-Bb 
Class: All alpha proteins
  Fold: DNA/RNA-binding 3-helical bundle
    Superfamily: "Winged helix" DNA-binding domain
      Family: ets domain
Serum response factor accessory protein 1a, SAP-1 H N/A N/A FX  L-Bb 
GO terms
Protein chains: GO type: GO description:
A/B/D/E=132-223 C nuclear chromatin
A/B/D/E=132-223 C nucleus
A/B/D/E=132-223 C endoplasmic reticulum
A/B/D/E=132-223 F RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
A/B/D/E=132-223 F serum response element binding
A/B/D/E=132-223 F RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
A/B/D/E=132-223 F RNA polymerase II transcription factor binding transcription factor activity
A/B/D/E=132-223 F sequence-specific DNA binding
A/B/D/E=132-223 F chromatin DNA binding
A/B/D/E=132-223 P contractile actin filament bundle assembly
A/B/D/E=132-223 P regulation of cell adhesion
A/B/D/E=132-223 P epithelial cell-cell adhesion
A/B/D/E=132-223 P heart trabecula formation
A/B/D/E=132-223 P positive thymic T cell selection
A/B/D/E=132-223 P response to toxin
A/B/D/E=132-223 P stress fiber assembly
A/B/D/E=132-223 P developmental growth
A/B/D/E=132-223 P megakaryocyte development
A/B/D/E=132-223 P morphogenesis of an epithelial sheet
A/B/D/E=132-223 P neuron development
A/B/D/E=132-223 P cell migration involved in sprouting angiogenesis
A/B/D/E=132-223 P platelet formation
A/B/D/E=132-223 P cardiac myofibril assembly
A/B/D/E=132-223 P cellular senescence
A/B/D/E=132-223 P cardiac vascular smooth muscle cell differentiation
A/B/D/E=132-223 P patterning of blood vessels
A/B/D/E=132-223 P skin morphogenesis
A/B/D/E=132-223 P regulation of smooth muscle cell differentiation
A/B/D/E=132-223 P long-term memory
A/B/D/E=132-223 P dorsal aorta morphogenesis
A/B/D/E=132-223 P response to hormone stimulus
A/B/D/E=132-223 P mesoderm formation
A/B/D/E=132-223 P tangential migration from the subventricular zone to the olfactory bulb
A/B/D/E=132-223 P cell-matrix adhesion
A/B/D/E=132-223 P positive regulation of cell differentiation
A/B/D/E=132-223 P hippocampus development
A/B/D/E=132-223 P negative regulation of cell proliferation
A/B/D/E=132-223 P positive regulation of smooth muscle contraction
A/B/D/E=132-223 P heart looping
A/B/D/E=132-223 P long term synaptic depression
A/B/D/E=132-223 P response to cytokine stimulus
A/B/D/E=132-223 P positive regulation of transcription via serum response element binding
A/B/D/E=132-223 P negative regulation of cell migration
A/B/D/E=132-223 P trophectodermal cell differentiation
A/B/D/E=132-223 P tight junction assembly
A/B/D/E=132-223 P associative learning
A/B/D/E=132-223 P neuron projection development
A/B/D/E=132-223 P primitive streak formation
A/B/D/E=132-223 P neuron migration
A/B/D/E=132-223 P positive regulation of transcription initiation from RNA polymerase II promoter
A/B/D/E=132-223 P angiogenesis involved in wound healing
A/B/D/E=132-223 P erythrocyte development
A/B/D/E=132-223 P sarcomere organization
A/B/D/E=132-223 P regulation of water loss via skin
A/B/D/E=132-223 P platelet activation
A/B/D/E=132-223 P epithelial structure maintenance
A/B/D/E=132-223 P hemopoietic stem cell differentiation
A/B/D/E=132-223 P eyelid development in camera-type eye
A/B/D/E=132-223 P positive regulation of filopodium assembly
A/B/D/E=132-223 P muscle cell homeostasis
G/H=2-156 C cytoplasm
G/H=2-156 F DNA binding
G/H=2-156 F transcription cofactor activity
G/H=2-156 F sequence-specific DNA binding transcription factor activity
Sequences
Download file with secondary structure created by Stride  
1hbx.pdb1.pdb:   [ download sequences in FASTA format ]
C (dna): 
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W (dna): 
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A (protein): 
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B (protein): 
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G (protein): 
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1hbx.pdb2.pdb:   [ download sequences in FASTA format ]
F (dna): 
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X (dna): 
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D (protein): 
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E (protein): 
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H (protein): 
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