General information
PDB ID 1HJB
Title CRYSTAL STRUCTURE OF RUNX-1/AML1/CBFALPHA RUNT DOMAIN AND C/EBPBETA BZIP DIMERIC BOUND TO A DNA FRAGMENT FROM THE CSF-1R PROMOTER
PDB header TRANSCRIPTION/DNA
Date 2001-01-11
Experimental method X-RAY DIFFRACTION
Resolution (A) 3
Kind dna
Organism HOMO SAPIENS, MUS MUSCULUS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb1hjb.pdb ABCDEF GHIJ 0
Biounits:
1hjb.pdb1.pdb ABC GH 1
1hjb.pdb2.pdb DEF IJ 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Taxilin Coiled-coil 0.00085 0 No_clan D 276 335 IJ
Taxilin Coiled-coil 0.00085 0 No_clan E 276 335 IJ
Runt Domain Q03347_60-179 4.8e-72 1 CL0073 C 60 179 GH  S-Bb S-Mj L-Bb L-Mj L-Mn 
Runt Domain Q03347_60-179 4.8e-72 1 CL0073 F 60 179 IJ  S-Bb S-Mj L-Bb L-Mj L-Mn 
bZIP_2 Family P17676_270-323 1.1e-19 1 CL0018 A 270 323 GH  H-Bb H-Mj 
bZIP_2 Family P17676_270-323 1.2e-19 1 CL0018 B 270 323 GH  H-Bb H-Mj 
bZIP_2 Family P17676_270-323 1.3e-19 1 CL0018 D 270 323 IJ  H-Bb H-Mj 
bZIP_2 Family P17676_270-323 1.3e-19 1 CL0018 E 270 323 IJ  H-Bb H-Mj 
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: All beta proteins
  Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f
    Superfamily: p53-like transcription factors
      Family: RUNT domain
Acute myeloid leukemia 1 protein (AML1), RUNT domain C N/A N/A GH  S-Bb S-Mj L-Bb L-Mj L-Mn 
Class: All beta proteins
  Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f
    Superfamily: p53-like transcription factors
      Family: RUNT domain
Acute myeloid leukemia 1 protein (AML1), RUNT domain F N/A N/A IJ  S-Bb S-Mj L-Bb L-Mj L-Mn 
Class: Coiled coil proteins
  Fold: Parallel coiled-coil
    Superfamily: Leucine zipper domain
      Family: Leucine zipper domain
C/ebp beta A N/A N/A GH  H-Bb H-Mj 
Class: Coiled coil proteins
  Fold: Parallel coiled-coil
    Superfamily: Leucine zipper domain
      Family: Leucine zipper domain
C/ebp beta B N/A N/A GH  H-Bb H-Mj 
Class: Coiled coil proteins
  Fold: Parallel coiled-coil
    Superfamily: Leucine zipper domain
      Family: Leucine zipper domain
C/ebp beta D N/A N/A IJ  H-Bb H-Mj L-Bb 
Class: Coiled coil proteins
  Fold: Parallel coiled-coil
    Superfamily: Leucine zipper domain
      Family: Leucine zipper domain
C/ebp beta E N/A N/A IJ  H-Bb H-Mj 
GO terms
Protein chains: GO type: GO description:
A/B/D/E=259-345 C nuclear chromatin
A/B/D/E=259-345 C cytoplasm
A/B/D/E=259-345 C nuclear matrix
A/B/D/E=259-345 F sequence-specific DNA binding
A/B/D/E=259-345 F RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
A/B/D/E=259-345 F RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
A/B/D/E=259-345 P embryonic placenta development
A/B/D/E=259-345 P neuron differentiation
A/B/D/E=259-345 P induction of apoptosis
A/B/D/E=259-345 P positive regulation of osteoblast differentiation
A/B/D/E=259-345 P cellular response to amino acid stimulus
A/B/D/E=259-345 P mammary gland epithelial cell proliferation
A/B/D/E=259-345 P brown fat cell differentiation
A/B/D/E=259-345 P negative regulation of transcription, DNA-dependent
A/B/D/E=259-345 P response to lipopolysaccharide
A/B/D/E=259-345 P mammary gland epithelial cell differentiation
A/B/D/E=259-345 P anti-apoptosis
A/B/D/E=259-345 P immune response
A/B/D/E=259-345 P acute-phase response
A/B/D/E=259-345 P regulation of interleukin-6 biosynthetic process
C/F=60-182 C basement membrane
C/F=60-182 C nucleus
C/F=60-182 F ATP binding
C/F=60-182 F sequence-specific DNA binding transcription factor activity
C/F=60-182 F DNA binding
C/F=60-182 P transcription, DNA-dependent
C/F=60-182 P neuron development
C/F=60-182 P response to retinoic acid
C/F=60-182 P hair follicle morphogenesis
C/F=60-182 P myeloid progenitor cell differentiation
C/F=60-182 P positive regulation of granulocyte differentiation
C/F=60-182 P liver development
C/F=60-182 P positive regulation of transcription from RNA polymerase II promoter
C/F=60-182 P regulation of signal transduction
C/F=60-182 P in utero embryonic development
C/F=60-182 P central nervous system development
C/F=60-182 P embryonic hemopoiesis
C/F=60-182 P skeletal system development
C/F=60-182 P behavioral response to pain
C/F=60-182 P positive regulation of angiogenesis
C/F=60-182 P regulation of hair follicle cell proliferation
C/F=60-182 P definitive hemopoiesis
Sequences
Download file with secondary structure created by Stride  
1hjb.pdb1.pdb:   [ download sequences in FASTA format ]
G (dna): 
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H (dna): 
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A (protein): 
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B (protein): 
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C (protein): 
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1hjb.pdb2.pdb:   [ download sequences in FASTA format ]
I (dna): 
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J (dna): 
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D (protein): 
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E (protein): 
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F (protein): 
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