General information
PDB ID 1HVU
Title HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REVERSE TRANSCRIPTASE COMPLEXED WITH A 33-BASE NUCLEOTIDE RNA PSEUDOKNOT
PDB header TRANSFERASE/RNA
Date 1998-06-30
Experimental method X-RAY DIFFRACTION
Resolution (A) 4.75
Kind rna
Organism HUMAN IMMUNODEFICIENCY VIRUS 1
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
PRIDB
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb1hvu.pdb ABDGJEHK CFIL 0
Biounits:
1hvu.pdb1.pdb AB C 1
1hvu.pdb2.pdb DE F 1
1hvu.pdb3.pdb GH I 1
1hvu.pdb4.pdb JK L 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
RVT_connect Domain P03366_917-1018 2.2e-59 1 No_clan A 318 419   
RNase_H Domain P03366_1035-1153 2.4e-28 1 CL0219 A 436 554 C   
RVT_thumb Domain P03366_840-903 1.8e-20 1 No_clan A 241 304   
RVT_connect Domain P03366_917-1018 1.2e-59 1 No_clan B 318 419 C   
RVT_thumb Domain P03366_840-903 1.1e-20 1 No_clan B 241 304   
RVT_connect Domain P03366_917-1018 2.2e-59 1 No_clan D 318 419   
RNase_H Domain P03366_1035-1153 2.4e-28 1 CL0219 D 436 554 F   
RVT_thumb Domain P03366_840-903 1.8e-20 1 No_clan D 241 304   
RVT_connect Domain P03366_917-1018 1.2e-59 1 No_clan E 318 419 F   
RVT_thumb Domain P03366_840-903 1.1e-20 1 No_clan E 241 304   
RVT_connect Domain P03366_917-1018 2.2e-59 1 No_clan G 318 419   
RNase_H Domain P03366_1035-1153 2.4e-28 1 CL0219 G 436 554 I   
RVT_thumb Domain P03366_840-903 1.8e-20 1 No_clan G 241 304   
RVT_connect Domain P03366_917-1018 1.2e-59 1 No_clan H 318 419 I   
RVT_thumb Domain P03366_840-903 1.1e-20 1 No_clan H 241 304   
RVT_connect Domain P03366_917-1018 2.2e-59 1 No_clan J 318 419   
RNase_H Domain P03366_1035-1153 2.4e-28 1 CL0219 J 436 554 L   
RVT_thumb Domain P03366_840-903 1.8e-20 1 No_clan J 241 304   
RVT_connect Domain P03366_917-1018 1.2e-59 1 No_clan K 318 419 L   
RVT_thumb Domain P03366_840-903 1.1e-20 1 No_clan K 241 304   
RVT_1 Family P03366_662-833 1.4e-34 1 CL0027 A 63 234   
RVT_1 Family P03366_662-810 4.3e-31 1 CL0027 B 63 240   
RVT_1 Family P03366_662-833 1.4e-34 1 CL0027 D 63 234   
RVT_1 Family P03366_662-810 4.3e-31 1 CL0027 E 63 240   
RVT_1 Family P03366_662-833 1.4e-34 1 CL0027 G 63 234   
RVT_1 Family P03366_662-810 4.3e-31 1 CL0027 H 63 240   
RVT_1 Family P03366_662-833 1.4e-34 1 CL0027 J 63 234   
RVT_1 Family P03366_662-810 4.3e-31 1 CL0027 K 63 240   
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: Alpha and beta proteins (a/b)
  Fold: Ribonuclease H-like motif
    Superfamily: Ribonuclease H-like
      Family: Ribonuclease H
HIV RNase H (Domain of reverse transcriptase) A 430 554 C -
Class: Alpha and beta proteins (a/b)
  Fold: Ribonuclease H-like motif
    Superfamily: Ribonuclease H-like
      Family: Ribonuclease H
HIV RNase H (Domain of reverse transcriptase) D 430 554 F -
Class: Alpha and beta proteins (a/b)
  Fold: Ribonuclease H-like motif
    Superfamily: Ribonuclease H-like
      Family: Ribonuclease H
HIV RNase H (Domain of reverse transcriptase) G 430 554 I -
Class: Alpha and beta proteins (a/b)
  Fold: Ribonuclease H-like motif
    Superfamily: Ribonuclease H-like
      Family: Ribonuclease H
HIV RNase H (Domain of reverse transcriptase) J 430 554 L -
Class: Multi-domain proteins (alpha and beta)
  Fold: DNA/RNA polymerases
    Superfamily: DNA/RNA polymerases
      Family: Reverse transcriptase
HIV-1 reverse transcriptase A 1 429 -
Class: Multi-domain proteins (alpha and beta)
  Fold: DNA/RNA polymerases
    Superfamily: DNA/RNA polymerases
      Family: Reverse transcriptase
HIV-1 reverse transcriptase B N/A N/A C -
Class: Multi-domain proteins (alpha and beta)
  Fold: DNA/RNA polymerases
    Superfamily: DNA/RNA polymerases
      Family: Reverse transcriptase
HIV-1 reverse transcriptase D 1 429 -
Class: Multi-domain proteins (alpha and beta)
  Fold: DNA/RNA polymerases
    Superfamily: DNA/RNA polymerases
      Family: Reverse transcriptase
HIV-1 reverse transcriptase E N/A N/A F -
Class: Multi-domain proteins (alpha and beta)
  Fold: DNA/RNA polymerases
    Superfamily: DNA/RNA polymerases
      Family: Reverse transcriptase
HIV-1 reverse transcriptase G 1 429 -
Class: Multi-domain proteins (alpha and beta)
  Fold: DNA/RNA polymerases
    Superfamily: DNA/RNA polymerases
      Family: Reverse transcriptase
HIV-1 reverse transcriptase H N/A N/A I -
Class: Multi-domain proteins (alpha and beta)
  Fold: DNA/RNA polymerases
    Superfamily: DNA/RNA polymerases
      Family: Reverse transcriptase
HIV-1 reverse transcriptase J 1 429 -
Class: Multi-domain proteins (alpha and beta)
  Fold: DNA/RNA polymerases
    Superfamily: DNA/RNA polymerases
      Family: Reverse transcriptase
HIV-1 reverse transcriptase K N/A N/A L -
GO terms
Protein chains: GO type: GO description:
A/D/G/J=600-1153, B/E/H/K=604-1026 C host cell cytoplasm
A/D/G/J=600-1153, B/E/H/K=604-1026 C host cell plasma membrane
A/D/G/J=600-1153, B/E/H/K=604-1026 C viral capsid
A/D/G/J=600-1153, B/E/H/K=604-1026 C nucleoplasm
A/D/G/J=600-1153, B/E/H/K=604-1026 C cytosol
A/D/G/J=600-1153, B/E/H/K=604-1026 C host cell nucleus
A/D/G/J=600-1153, B/E/H/K=604-1026 C membrane
A/D/G/J=600-1153, B/E/H/K=604-1026 F exoribonuclease H activity
A/D/G/J=600-1153, B/E/H/K=604-1026 F zinc ion binding
A/D/G/J=600-1153, B/E/H/K=604-1026 F aspartic-type endopeptidase activity
A/D/G/J=600-1153, B/E/H/K=604-1026 F DNA-directed DNA polymerase activity
A/D/G/J=600-1153, B/E/H/K=604-1026 F ribonuclease H activity
A/D/G/J=600-1153, B/E/H/K=604-1026 F RNA binding
A/D/G/J=600-1153, B/E/H/K=604-1026 F structural molecule activity
A/D/G/J=600-1153, B/E/H/K=604-1026 F RNA-directed DNA polymerase activity
A/D/G/J=600-1153, B/E/H/K=604-1026 F DNA binding
A/D/G/J=600-1153, B/E/H/K=604-1026 P provirus integration
A/D/G/J=600-1153, B/E/H/K=604-1026 P RNA-dependent DNA replication
A/D/G/J=600-1153, B/E/H/K=604-1026 P uncoating of virus
A/D/G/J=600-1153, B/E/H/K=604-1026 P proteolysis
A/D/G/J=600-1153, B/E/H/K=604-1026 P modulation by virus of host apoptosis
A/D/G/J=600-1153, B/E/H/K=604-1026 P nucleic acid phosphodiester bond hydrolysis
A/D/G/J=600-1153, B/E/H/K=604-1026 P entry into host cell
A/D/G/J=600-1153, B/E/H/K=604-1026 P viral procapsid maturation
Sequences
Download file with secondary structure created by Stride  
1hvu.pdb1.pdb:   [ download sequences in FASTA format ]
A (protein): 
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B (protein): 
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C (rna): 
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1hvu.pdb2.pdb:   [ download sequences in FASTA format ]
D (protein): 
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E (protein): 
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F (rna): 
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1hvu.pdb3.pdb:   [ download sequences in FASTA format ]
G (protein): 
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H (protein): 
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I (rna): 
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1hvu.pdb4.pdb:   [ download sequences in FASTA format ]
J (protein): 
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K (protein): 
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L (rna): 
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