General information
PDB ID 1HYS
Title CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH A POLYPURINE TRACT RNA:DNA
PDB header TRANSFERASE/DNA-RNA HYBRID
Date 2001-01-22
Experimental method X-RAY DIFFRACTION
Resolution (A) 3
Kind hybrid
Organism HUMAN IMMUNODEFICIENCY VIRUS 1, MUS MUSCULUS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
PRIDB
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb1hys.pdb ABCD F E 0
Biounits:
1hys.pdb1.pdb ABCD F E 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
RVT_connect Domain P03366_917-1018 2.2e-59 1 No_clan A 318 419 EF   
RNase_H Domain P03366_1035-1153 3.4e-28 1 CL0219 A 436 553 EF   
RVT_thumb Domain P03366_840-903 5.8e-20 1 No_clan A 241 304 EF   
RVT_connect Domain P03366_917-1018 1.4e-59 1 No_clan B 318 419   
RVT_thumb Domain P03366_840-903 3.9e-20 1 No_clan B 241 304   
C1-set Domain 2.5e-23 1 CL0011 C 115 201
V-set Domain 3.3e-18 1 CL0011 C 6 107
C1-set Domain 5.9e-16 1 CL0011 D 131 212
V-set Domain 2.2e-15 1 CL0011 D 6 122
RVT_1 Family P03366_662-833 1.4e-34 1 CL0027 A 63 234 EF   
RVT_1 Family P03366_662-833 8e-35 1 CL0027 B 63 234   
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: Alpha and beta proteins (a/b)
  Fold: Ribonuclease H-like motif
    Superfamily: Ribonuclease H-like
      Family: Ribonuclease H
HIV RNase H (Domain of reverse transcriptase) A 430 553 EF -
Class: Multi-domain proteins (alpha and beta)
  Fold: DNA/RNA polymerases
    Superfamily: DNA/RNA polymerases
      Family: Reverse transcriptase
HIV-1 reverse transcriptase A 1 429 EF -
Class: Multi-domain proteins (alpha and beta)
  Fold: DNA/RNA polymerases
    Superfamily: DNA/RNA polymerases
      Family: Reverse transcriptase
HIV-1 reverse transcriptase B N/A N/A E -
Class: All beta proteins
  Fold: Immunoglobulin-like beta-sandwich
    Superfamily: Immunoglobulin
      Family: V set domains (antibody variable domain-like)
Immunoglobulin light chain kappa variable domain, VL-kappa C 1 107 -
Class: All beta proteins
  Fold: Immunoglobulin-like beta-sandwich
    Superfamily: Immunoglobulin
      Family: C1 set domains (antibody constant domain-like)
Immunoglobulin light chain kappa constant domain, CL-kappa C 108 214 -
Class: All beta proteins
  Fold: Immunoglobulin-like beta-sandwich
    Superfamily: Immunoglobulin
      Family: V set domains (antibody variable domain-like)
Immunoglobulin heavy chain variable domain, VH D 1 123 -
Class: All beta proteins
  Fold: Immunoglobulin-like beta-sandwich
    Superfamily: Immunoglobulin
      Family: C1 set domains (antibody constant domain-like)
Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma D 124 220 -
GO terms
Protein chains: GO type: GO description:
A=600-1152, B=600-1024 C host cell cytoplasm
A=600-1152, B=600-1024 C host cell nucleus
A=600-1152, B=600-1024 C membrane
A=600-1152, B=600-1024 C nucleoplasm
A=600-1152, B=600-1024 C host cell plasma membrane
A=600-1152, B=600-1024 C viral capsid
A=600-1152, B=600-1024 C cytosol
A=600-1152, B=600-1024 F DNA binding
A=600-1152, B=600-1024 F zinc ion binding
A=600-1152, B=600-1024 F RNA-directed DNA polymerase activity
A=600-1152, B=600-1024 F structural molecule activity
A=600-1152, B=600-1024 F RNA binding
A=600-1152, B=600-1024 F exoribonuclease H activity
A=600-1152, B=600-1024 F ribonuclease H activity
A=600-1152, B=600-1024 F DNA-directed DNA polymerase activity
A=600-1152, B=600-1024 F aspartic-type endopeptidase activity
A=600-1152, B=600-1024 P proteolysis
A=600-1152, B=600-1024 P viral procapsid maturation
A=600-1152, B=600-1024 P uncoating of virus
A=600-1152, B=600-1024 P entry into host cell
A=600-1152, B=600-1024 P modulation by virus of host apoptosis
A=600-1152, B=600-1024 P provirus integration
A=600-1152, B=600-1024 P RNA-dependent DNA replication
A=600-1152, B=600-1024 P nucleic acid phosphodiester bond hydrolysis
Sequences
Download file with secondary structure created by Stride  
1hys.pdb1.pdb:   [ download sequences in FASTA format ]
F (dna): 
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A (protein): 
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B (protein): 
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C (protein): 
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D (protein): 
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E (rna): 
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