General information
PDB ID 1IF1
Title INTERFERON REGULATORY FACTOR 1 (IRF-1) COMPLEX WITH DNA
PDB header TRANSCRIPTION/DNA
Date 1997-09-12
Experimental method X-RAY DIFFRACTION
Resolution (A) 3
Kind dna
Organism SYNTHETIC CONSTRUCT, MUS MUSCULUS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb1if1.pdb AB CD 0
Biounits:
1if1.pdb1.pdb AB CD 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
IRF Domain P15314_7-111 5.2e-42 1 CL0123 A 7 111 C  H-Bb H-Mj L-Bb 
IRF Domain P15314_7-111 1.9e-41 1 CL0123 B 8 111 D  H-Bb H-Mj L-Bb 
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: All alpha proteins
  Fold: DNA/RNA-binding 3-helical bundle
    Superfamily: "Winged helix" DNA-binding domain
      Family: Interferon regulatory factor
Interferon regulatory factor 1 (IRF-1) A N/A N/A C  H-Bb H-Mj L-Bb 
Class: All alpha proteins
  Fold: DNA/RNA-binding 3-helical bundle
    Superfamily: "Winged helix" DNA-binding domain
      Family: Interferon regulatory factor
Interferon regulatory factor 1 (IRF-1) B N/A N/A D  H-Bb H-Mj L-Bb 
GO terms
Protein chains: GO type: GO description:
A/B=1-113 C cytoplasm
A/B=1-113 C nucleus
A/B=1-113 F regulatory region DNA binding
A/B=1-113 F sequence-specific DNA binding
A/B=1-113 F sequence-specific DNA binding transcription factor activity
A/B=1-113 P negative regulation of transcription, DNA-dependent
A/B=1-113 P negative regulation of T-helper 2 cell differentiation
A/B=1-113 P CD8-positive, alpha-beta T cell differentiation
A/B=1-113 P I-kappaB kinase/NF-kappaB cascade
A/B=1-113 P response to heat
A/B=1-113 P cellular response to interleukin-1
A/B=1-113 P cellular response to tumor necrosis factor
A/B=1-113 P cellular response to mechanical stimulus
A/B=1-113 P transcription, DNA-dependent
A/B=1-113 P positive regulation of interleukin-12 biosynthetic process
A/B=1-113 P regulation of innate immune response
A/B=1-113 P negative regulation of regulatory T cell differentiation
A/B=1-113 P regulation of CD8-positive, alpha-beta T cell proliferation
A/B=1-113 P positive regulation of interferon-beta production
A/B=1-113 P cellular response to peptide hormone stimulus
A/B=1-113 P regulation of MyD88-dependent toll-like receptor signaling pathway
A/B=1-113 P induction of apoptosis
A/B=1-113 P protein phosphorylation
A/B=1-113 P cellular response to dsRNA
A/B=1-113 P response to growth hormone stimulus
A/B=1-113 P cell cycle arrest
A/B=1-113 P protein acetylation
A/B=1-113 P negative regulation of tyrosine phosphorylation of Stat1 protein
A/B=1-113 P cellular response to retinoic acid
A/B=1-113 P positive regulation of transcription from RNA polymerase II promoter
A/B=1-113 P defense response to virus
A/B=1-113 P interferon-gamma-mediated signaling pathway
A/B=1-113 P positive regulation of natural killer cell differentiation
A/B=1-113 P positive regulation of T-helper 1 cell differentiation
A/B=1-113 P female pregnancy
Sequences
Download file with secondary structure created by Stride  
1if1.pdb1.pdb:   [ download sequences in FASTA format ]
C (dna): 
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D (dna): 
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A (protein): 
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B (protein): 
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