General information
PDB ID 1IO4
Title CRYSTAL STRUCTURE OF RUNX-1/AML1/CBFALPHA RUNT DOMAIN- CBFBETA CORE DOMAIN HETERODIMER AND C/EBPBETA BZIP HOMODIMER BOUND TO A DNA FRAGMENT FROM THE CSF-1R PROMOTER
PDB header TRANSCRIPTION/DNA
Date 2001-01-10
Experimental method X-RAY DIFFRACTION
Resolution (A) 3
Kind dna
Organism HOMO SAPIENS, MUS MUSCULUS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb1io4.pdb ABCD EF 0
Biounits:
1io4.pdb1.pdb ABCD EF 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Runt Domain Q03347_60-179 4.8e-72 1 CL0073 C 60 179 EF  S-Bb S-Mj L-Bb L-Mj L-Mn 
bZIP_2 Family P17676_270-323 9.6e-20 1 CL0018 A 270 323 EF  H-Bb H-Mj 
bZIP_2 Family P17676_270-323 1.4e-19 1 CL0018 B 270 323 EF  H-Bb H-Mj 
CBF_beta Family Q08024_2-140 1.5e-67 1 No_clan D 2 140   
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: All beta proteins
  Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f
    Superfamily: p53-like transcription factors
      Family: RUNT domain
Acute myeloid leukemia 1 protein (AML1), RUNT domain C N/A N/A EF  S-Bb S-Mj L-Bb L-Mj L-Mn 
Class: Coiled coil proteins
  Fold: Parallel coiled-coil
    Superfamily: Leucine zipper domain
      Family: Leucine zipper domain
C/ebp beta A N/A N/A EF  H-Bb H-Mj 
Class: Coiled coil proteins
  Fold: Parallel coiled-coil
    Superfamily: Leucine zipper domain
      Family: Leucine zipper domain
C/ebp beta B N/A N/A EF  H-Bb H-Mj 
Class: All beta proteins
  Fold: Core binding factor beta, CBF
    Superfamily: Core binding factor beta, CBF
      Family: Core binding factor beta, CBF
Core binding factor beta, CBF D N/A N/A -
GO terms
Protein chains: GO type: GO description:
A/B=259-336 C cytoplasm
A/B=259-336 C nuclear matrix
A/B=259-336 C nuclear chromatin
A/B=259-336 F sequence-specific DNA binding
A/B=259-336 F RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
A/B=259-336 F RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
A/B=259-336 P anti-apoptosis
A/B=259-336 P cellular response to amino acid stimulus
A/B=259-336 P response to lipopolysaccharide
A/B=259-336 P mammary gland epithelial cell differentiation
A/B=259-336 P embryonic placenta development
A/B=259-336 P acute-phase response
A/B=259-336 P regulation of interleukin-6 biosynthetic process
A/B=259-336 P positive regulation of osteoblast differentiation
A/B=259-336 P brown fat cell differentiation
A/B=259-336 P immune response
A/B=259-336 P neuron differentiation
A/B=259-336 P mammary gland epithelial cell proliferation
A/B=259-336 P negative regulation of transcription, DNA-dependent
A/B=259-336 P induction of apoptosis
C=60-182 C basement membrane
C=60-182 F sequence-specific DNA binding transcription factor activity
C=60-182 F ATP binding
C=60-182 P regulation of signal transduction
C=60-182 P regulation of hair follicle cell proliferation
C=60-182 P myeloid progenitor cell differentiation
C=60-182 P positive regulation of angiogenesis
C=60-182 P central nervous system development
C=60-182 P skeletal system development
C=60-182 P in utero embryonic development
C=60-182 P hair follicle morphogenesis
C=60-182 P neuron development
C=60-182 P embryonic hemopoiesis
C=60-182 P positive regulation of granulocyte differentiation
C=60-182 P liver development
C=60-182 P transcription, DNA-dependent
C=60-182 P behavioral response to pain
C=60-182 P response to retinoic acid
D=1-141 C nucleus
D=1-141 F DNA binding
D=1-141 F transcription coactivator activity
D=1-141 P definitive hemopoiesis
D=1-141 P lymphocyte differentiation
D=1-141 P cell maturation
D=1-141 P osteoblast differentiation
D=1-141 P myeloid cell differentiation
D=1-141 P positive regulation of transcription from RNA polymerase II promoter
Sequences
Download file with secondary structure created by Stride  
1io4.pdb1.pdb:   [ download sequences in FASTA format ]
E (dna): 
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F (dna): 
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A (protein): 
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B (protein): 
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C (protein): 
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D (protein): 
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