General information
PDB ID 1J5O
Title CRYSTAL STRUCTURE OF MET184ILE MUTANT OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DOUBLE STRANDED DNA TEMPLATE- PRIMER
PDB header TRANSFERASE/IMMUNE SYSTEM/DNA
Date 2002-05-24
Experimental method X-RAY DIFFRACTION
Resolution (A) 3.5
Kind dna
Organism HUMAN IMMUNODEFICIENCY VIRUS 1, MUS MUSCULUS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb1j5o.pdb ABLH TP 0
Biounits:
1j5o.pdb1.pdb ABLH TP 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
RVT_connect Domain P03366_917-1018 2.5e-59 1 No_clan A 318 419 PT  S-Bb L-Bb 
RVT_1 Domain P03366_662-833 3.8e-34 1 CL0027 A 63 234 PT  L-Bb L-Mn 
RNase_H Domain P03366_1035-1153 5.5e-29 1 CL0219 A 436 557 P  H-Bb L-Bb 
RVT_thumb Domain P03366_840-903 2.2e-21 1 No_clan A 241 304 T  H-Bb L-Bb 
RVT_connect Domain P03366_917-1018 1.6e-59 1 No_clan B 318 419   
RVT_1 Domain P03366_662-833 2.2e-34 1 CL0027 B 63 234   
RVT_thumb Domain P03366_840-903 1.5e-21 1 No_clan B 241 304   
C1-set Domain 3.2e-16 1 CL0011 H 131 212
V-set Domain 1.2e-14 1 CL0011 H 6 122
C1-set Domain 6.9e-24 1 CL0011 L 115 201
V-set Domain 1.5e-17 1 CL0011 L 6 107
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: Alpha and beta proteins (a/b)
  Fold: Ribonuclease H-like motif
    Superfamily: Ribonuclease H-like
      Family: Ribonuclease H
HIV RNase H (Domain of reverse transcriptase) A 430 558 P -
Class: Multi-domain proteins (alpha and beta)
  Fold: DNA/RNA polymerases
    Superfamily: DNA/RNA polymerases
      Family: Reverse transcriptase
HIV-1 reverse transcriptase A 1 429 PT -
Class: Multi-domain proteins (alpha and beta)
  Fold: DNA/RNA polymerases
    Superfamily: DNA/RNA polymerases
      Family: Reverse transcriptase
HIV-1 reverse transcriptase B N/A N/A -
Class: All beta proteins
  Fold: Immunoglobulin-like beta-sandwich
    Superfamily: Immunoglobulin
      Family: V set domains (antibody variable domain-like)
Immunoglobulin heavy chain variable domain, VH H 1 123 -
Class: All beta proteins
  Fold: Immunoglobulin-like beta-sandwich
    Superfamily: Immunoglobulin
      Family: C1 set domains (antibody constant domain-like)
Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma H 124 220 -
Class: All beta proteins
  Fold: Immunoglobulin-like beta-sandwich
    Superfamily: Immunoglobulin
      Family: V set domains (antibody variable domain-like)
Immunoglobulin light chain kappa variable domain, VL-kappa L 1 107 -
Class: All beta proteins
  Fold: Immunoglobulin-like beta-sandwich
    Superfamily: Immunoglobulin
      Family: C1 set domains (antibody constant domain-like)
Immunoglobulin light chain kappa constant domain, CL-kappa L 108 214 -
GO terms
Protein chains: GO type: GO description:
A=600-1157, B=600-1029 C host cell nucleus
A=600-1157, B=600-1029 C host cell plasma membrane
A=600-1157, B=600-1029 C host multivesicular body
A=600-1157, B=600-1029 C viral nucleocapsid
A=600-1157, B=600-1029 C virion membrane
A=600-1157, B=600-1029 F aspartic-type endopeptidase activity
A=600-1157, B=600-1029 F DNA binding
A=600-1157, B=600-1029 F DNA-directed DNA polymerase activity
A=600-1157, B=600-1029 F exoribonuclease H activity
A=600-1157, B=600-1029 F lipid binding
A=600-1157, B=600-1029 F RNA binding
A=600-1157, B=600-1029 F RNA-directed DNA polymerase activity
A=600-1157, B=600-1029 F RNA-DNA hybrid ribonuclease activity
A=600-1157, B=600-1029 F structural molecule activity
A=600-1157, B=600-1029 F zinc ion binding
A=600-1157, B=600-1029 P DNA integration
A=600-1157, B=600-1029 P DNA recombination
A=600-1157, B=600-1029 P establishment of integrated proviral latency
A=600-1157, B=600-1029 P induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process
A=600-1157, B=600-1029 P suppression by virus of host gene expression
A=600-1157, B=600-1029 P viral entry into host cell
A=600-1157, B=600-1029 P viral genome integration into host DNA
A=600-1157, B=600-1029 P viral penetration into host nucleus
Sequences
Download file with secondary structure created by Stride  
1j5o.pdb1.pdb:   [ download sequences in FASTA format ]
P (dna): 
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T (dna): 
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A (protein): 
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B (protein): 
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H (protein): 
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L (protein): 
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