General information
PDB ID 1K4T
Title HUMAN DNA TOPOISOMERASE I (70 KDA) IN COMPLEX WITH THE POISON TOPOTECAN AND COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX
PDB header ISOMERASE/DNA
Date 2001-10-08
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.1
Kind dna
Organism HOMO SAPIENS
Download
complex
View in
Jmol
Quick Links
PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
 PDIdb 
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb1k4t.pdb A BCD 0
Biounits:
1k4t.pdb1.pdb A BCD 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Topoisom_I Domain P11387_432-665 8.5e-103 1 CL0382 A 432 665 BD  H-Bb H-Mn L-Bb L-Mj 
Topoisom_I_N Family P11387_215-429 1.4e-101 1 No_clan A 215 429 BCD  H-Bb S-Bb S-Mj L-Bb L-Mn 
Topo_C_assoc Family P11387_695-765 5.2e-31 1 No_clan A 695 765 CB  H-Bb 
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: All alpha proteins
  Fold: Long alpha-hairpin
    Superfamily: Eukaryotic DNA topoisomerase I, dispensable insert domain
      Family: Eukaryotic DNA topoisomerase I, dispensable insert domain
Eukaryotic DNA topoisomerase I, dispensable insert domain A 641 712 -
Class: Alpha and beta proteins (a+b)
  Fold: DNA breaking-rejoining enzymes
    Superfamily: DNA breaking-rejoining enzymes
      Family: Eukaryotic DNA topoisomerase I, catalytic core
Eukaryotic DNA topoisomerase I, catalytic core A 431 640 CB  H-Bb H-Mn L-Bb 
Class: Alpha and beta proteins (a+b)
  Fold: DNA breaking-rejoining enzymes
    Superfamily: DNA breaking-rejoining enzymes
      Family: Eukaryotic DNA topoisomerase I, catalytic core
Eukaryotic DNA topoisomerase I, catalytic core A 713 765 CB  H-Bb 
Class: Alpha and beta proteins (a+b)
  Fold: DNA breaking-rejoining enzymes
    Superfamily: DNA breaking-rejoining enzymes
      Family: Eukaryotic DNA topoisomerase I, catalytic core
Eukaryotic DNA topoisomerase I, catalytic core A 431 640 BD  H-Bb H-Mn L-Bb 
Class: Alpha and beta proteins (a+b)
  Fold: DNA breaking-rejoining enzymes
    Superfamily: DNA breaking-rejoining enzymes
      Family: Eukaryotic DNA topoisomerase I, catalytic core
Eukaryotic DNA topoisomerase I, catalytic core A 713 765 BD  H-Bb 
Class: Multi-domain proteins (alpha and beta)
  Fold: Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment
    Superfamily: Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment
      Family: Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment A 201 430 BCD  H-Bb S-Bb S-Mj L-Bb 
GO terms
Protein chains: GO type: GO description:
A=174-765 C cytoplasmic mRNA processing body
A=174-765 C replication fork protection complex
A=174-765 C perikaryon
A=174-765 C nucleolus
A=174-765 C nucleoplasm
A=174-765 F ATP binding
A=174-765 F DNA topoisomerase type I activity
A=174-765 F chromatin binding
A=174-765 F DNA topoisomerase (ATP-hydrolyzing) activity
A=174-765 P chromatin remodeling
A=174-765 P embryonic cleavage
A=174-765 P DNA topological change
A=174-765 P chromosome segregation
A=174-765 P programmed cell death
A=174-765 P phosphorylation
A=174-765 P response to drug
A=174-765 P DNA replication
A=174-765 P virus-host interaction
Sequences
Download file with secondary structure created by Stride  
1k4t.pdb1.pdb:   [ download sequences in FASTA format ]
B (dna): 
Click "SHOW" for view sequence
C (dna): 
Click "SHOW" for view sequence
D (dna): 
Click "SHOW" for view sequence
A (protein): 
Click "SHOW" for view sequence
© NPIDB team 2003 - 2019

text