General information
PDB ID 1K78
Title PAX5(1-149)+ETS-1(331-440)+DNA
PDB header TRANSCRIPTION/DNA
Date 2001-10-18
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.25
Kind dna
Organism HOMO SAPIENS, MUS MUSCULUS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
 PDIdb 
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb1k78.pdb ABEFI CDGH 0
Biounits:
1k78.pdb1.pdb ABI CD 1
1k78.pdb2.pdb EF GH 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
PAX Domain Q02548_19-140 2.9e-74 1 CL0123 A 19 140 CD  H-Bb H-Mj L-Bb L-Mj L-Mn 
Ets Domain P27577_336-415 2.5e-38 1 CL0123 B 336 415 CD  H-Bb H-Mj L-Bb 
PAX Domain Q02548_19-140 2.9e-74 1 CL0123 E 19 140 GH  H-Bb H-Mj L-Bb L-Mj L-Mn 
Ets Domain P27577_336-415 2.6e-38 1 CL0123 F 336 415 GH  H-Bb H-Mj S-Bb L-Bb 
PAX Domain Q02548_84-140 1.5e-28 1 CL0123 I 84 140 CD  H-Bb H-Mj L-Bb L-Mn 
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: All alpha proteins
  Fold: DNA/RNA-binding 3-helical bundle
    Superfamily: Homeodomain-like
      Family: Paired domain
Pax-5 A 19 81 CD  H-Bb H-Mj L-Bb L-Mj L-Mn 
Class: All alpha proteins
  Fold: DNA/RNA-binding 3-helical bundle
    Superfamily: Homeodomain-like
      Family: Paired domain
Pax-5 A 82 142 CD  H-Bb H-Mj L-Bb L-Mn 
Class: All alpha proteins
  Fold: DNA/RNA-binding 3-helical bundle
    Superfamily: "Winged helix" DNA-binding domain
      Family: ets domain
ETS-1 transcription factor, residues 331-440 B N/A N/A CD  H-Bb H-Mj L-Bb 
Class: All alpha proteins
  Fold: DNA/RNA-binding 3-helical bundle
    Superfamily: Homeodomain-like
      Family: Paired domain
Pax-5 E 19 81 GH  H-Bb H-Mj L-Bb L-Mj L-Mn 
Class: All alpha proteins
  Fold: DNA/RNA-binding 3-helical bundle
    Superfamily: Homeodomain-like
      Family: Paired domain
Pax-5 E 82 142 GH  H-Bb H-Mj L-Bb L-Mn 
Class: All alpha proteins
  Fold: DNA/RNA-binding 3-helical bundle
    Superfamily: "Winged helix" DNA-binding domain
      Family: ets domain
ETS-1 transcription factor, residues 331-440 F N/A N/A GH  H-Bb H-Mj S-Bb L-Bb 
Class: All alpha proteins
  Fold: DNA/RNA-binding 3-helical bundle
    Superfamily: Homeodomain-like
      Family: Paired domain
Pax-5 I 84 141 CD  H-Bb H-Mj L-Bb L-Mn 
GO terms
Protein chains: GO type: GO description:
A/E/I=1-149 C nucleus
A/E/I=1-149 F DNA binding
A/E/I=1-149 P organ morphogenesis
A/E/I=1-149 P cell differentiation
A/E/I=1-149 P negative regulation of transcription from RNA polymerase II promoter
A/E/I=1-149 P nervous system development
A/E/I=1-149 P humoral immune response
A/E/I=1-149 P spermatogenesis
A/E/I=1-149 P negative regulation of histone H3-K9 methylation
B/F=331-440 C transcription factor complex
B/F=331-440 F sequence-specific DNA binding transcription factor activity
B/F=331-440 F sequence-specific DNA binding
B/F=331-440 P positive regulation of cell migration
B/F=331-440 P transcription from RNA polymerase II promoter
B/F=331-440 P cell motility
B/F=331-440 P pituitary gland development
B/F=331-440 P response to hypoxia
B/F=331-440 P negative regulation of cell cycle
B/F=331-440 P induction of apoptosis
B/F=331-440 P estrous cycle phase
B/F=331-440 P PML body organization
B/F=331-440 P response to interleukin-1
B/F=331-440 P positive regulation of erythrocyte differentiation
B/F=331-440 P cellular response to hydrogen peroxide
B/F=331-440 P response to antibiotic
B/F=331-440 P positive regulation of cell proliferation
B/F=331-440 P positive regulation of angiogenesis
B/F=331-440 P response to laminar fluid shear stress
B/F=331-440 P response to mechanical stimulus
B/F=331-440 P female pregnancy
B/F=331-440 P hypothalamus development
B/F=331-440 P anti-apoptosis
B/F=331-440 P regulation of extracellular matrix disassembly
B/F=331-440 P angiogenesis involved in wound healing
B/F=331-440 P positive regulation of transcription from RNA polymerase II promoter
B/F=331-440 P response to estradiol stimulus
Sequences
Download file with secondary structure created by Stride  
1k78.pdb1.pdb:   [ download sequences in FASTA format ]
C (dna): 
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D (dna): 
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A (protein): 
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B (protein): 
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I (protein): 
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1k78.pdb2.pdb:   [ download sequences in FASTA format ]
G (dna): 
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H (dna): 
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E (protein): 
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F (protein): 
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