General information
PDB ID 1LE5
Title CRYSTAL STRUCTURE OF A NF-KB HETERODIMER BOUND TO AN IFNB-KB
PDB header TRANSCRIPTION/DNA
Date 2002-04-09
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.75
Kind dna
Organism MUS MUSCULUS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb1le5.pdb ABEF CDGH 0
Biounits:
1le5.pdb1.pdb AB CD 1
1le5.pdb2.pdb EF GH 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
RHD_DNA_bind Domain Q04207_21-186 6.9e-70 1 CL0073 A 21 186 CD  L-Bb L-Mj 
RHD_dimer Domain Q04207_195-291 2.1e-37 1 CL0159 A 195 291 C  L-Bb 
RHD_DNA_bind Domain P25799_42-240 7.3e-74 1 CL0073 B 42 240 CD  S-Bb S-Mj L-Bb L-Mj 
RHD_dimer Domain P25799_249-350 5.5e-42 1 CL0159 B 249 350 D  L-Bb 
RHD_DNA_bind Domain Q04207_21-186 6.9e-70 1 CL0073 E 21 186 GH  S-Mj L-Bb L-Mj 
RHD_dimer Domain Q04207_195-291 2.1e-37 1 CL0159 E 195 291 G  L-Bb 
RHD_DNA_bind Domain P25799_42-240 7.3e-74 1 CL0073 F 42 240 GH  H-Bb H-Mj S-Bb S-Mj L-Bb L-Mj 
RHD_dimer Domain P25799_249-350 5.5e-42 1 CL0159 F 249 350 H  L-Bb 
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: All beta proteins
  Fold: Immunoglobulin-like beta-sandwich
    Superfamily: E set domains
      Family: NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain
p65 subunit of NF-kappa B (NFKB), dimerization domain A 192 291 C  L-Bb 
Class: All beta proteins
  Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f
    Superfamily: p53-like transcription factors
      Family: Rel/Dorsal transcription factors, DNA-binding domain
p65 subunit of NF-kappa B (NFKB), N-terminal domain A 18 191 CD  L-Bb L-Mj 
Class: All beta proteins
  Fold: Immunoglobulin-like beta-sandwich
    Superfamily: E set domains
      Family: NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain
p50 subunit of NF-kappa B transcription factor B 251 350 D  L-Bb 
Class: All beta proteins
  Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f
    Superfamily: p53-like transcription factors
      Family: Rel/Dorsal transcription factors, DNA-binding domain
p50 subunit of NF-kappa B (NFKB), N-terminal domain B 38 250 CD  L-Bb L-Mj 
Class: All beta proteins
  Fold: Immunoglobulin-like beta-sandwich
    Superfamily: E set domains
      Family: NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain
p65 subunit of NF-kappa B (NFKB), dimerization domain E 192 291 G  L-Bb 
Class: All beta proteins
  Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f
    Superfamily: p53-like transcription factors
      Family: Rel/Dorsal transcription factors, DNA-binding domain
p65 subunit of NF-kappa B (NFKB), N-terminal domain E 18 191 GH  L-Bb L-Mj 
Class: All beta proteins
  Fold: Immunoglobulin-like beta-sandwich
    Superfamily: E set domains
      Family: NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain
p50 subunit of NF-kappa B transcription factor F 251 350 H  L-Bb 
Class: All beta proteins
  Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f
    Superfamily: p53-like transcription factors
      Family: Rel/Dorsal transcription factors, DNA-binding domain
p50 subunit of NF-kappa B (NFKB), N-terminal domain F 38 250 GH  H-Bb H-Mj S-Bb S-Mj L-Bb L-Mj 
GO terms
Protein chains: GO type: GO description:
A/E=20-291 C NF-kappaB complex
A/E=20-291 F RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
A/E=20-291 F chromatin binding
A/E=20-291 F DNA binding
A/E=20-291 P defense response
A/E=20-291 P positive regulation of cell proliferation
A/E=20-291 P regulation of inflammatory response
A/E=20-291 P negative regulation of insulin receptor signaling pathway
A/E=20-291 P response to cytokine stimulus
A/E=20-291 P response to progesterone stimulus
A/E=20-291 P positive regulation of I-kappaB kinase/NF-kappaB cascade
A/E=20-291 P response to cobalamin
A/E=20-291 P response to muramyl dipeptide
A/E=20-291 P response to cAMP
A/E=20-291 P liver development
A/E=20-291 P positive regulation of interleukin-12 biosynthetic process
A/E=20-291 P response to hydrogen peroxide
A/E=20-291 P response to drug
A/E=20-291 P positive regulation of transcription, DNA-dependent
A/E=20-291 P hair follicle development
A/E=20-291 P negative regulation of protein catabolic process
A/E=20-291 P response to amino acid stimulus
A/E=20-291 P response to insulin stimulus
A/E=20-291 P organ morphogenesis
A/E=20-291 P aging
A/E=20-291 P positive regulation of Schwann cell differentiation
A/E=20-291 P cellular response to lipopolysaccharide
A/E=20-291 P positive regulation of NF-kappaB transcription factor activity
A/E=20-291 P positive regulation of chondrocyte differentiation
A/E=20-291 P response to morphine
A/E=20-291 P response to mechanical stimulus
A/E=20-291 P acetaldehyde metabolic process
B/F=39-350 C cytosol
B/F=39-350 C nucleus
B/F=39-350 C mitochondrion
B/F=39-350 C protein complex
B/F=39-350 F regulatory region DNA binding
B/F=39-350 F nucleic acid binding transcription factor activity
B/F=39-350 F transcription regulatory region sequence-specific DNA binding
B/F=39-350 F sequence-specific DNA binding transcription factor activity
B/F=39-350 F double-stranded DNA binding
B/F=39-350 F sequence-specific DNA binding
B/F=39-350 P signal transduction
B/F=39-350 P apoptotic process
B/F=39-350 P response to bacterium
B/F=39-350 P negative regulation of cytokine production
B/F=39-350 P response to oxidative stress
B/F=39-350 P lymph node development
B/F=39-350 P positive regulation of transcription from RNA polymerase II promoter
B/F=39-350 P negative regulation of transcription from RNA polymerase II promoter
B/F=39-350 P positive regulation of hyaluronan biosynthetic process
B/F=39-350 P transcription, DNA-dependent
B/F=39-350 P anti-apoptosis
B/F=39-350 P response to copper ion
B/F=39-350 P positive regulation of canonical Wnt receptor signaling pathway
B/F=39-350 P cellular response to interleukin-1
B/F=39-350 P cellular response to mechanical stimulus
B/F=39-350 P negative regulation of calcidiol 1-monooxygenase activity
B/F=39-350 P negative regulation of interleukin-12 biosynthetic process
Sequences
Download file with secondary structure created by Stride  
1le5.pdb1.pdb:   [ download sequences in FASTA format ]
C (dna): 
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D (dna): 
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A (protein): 
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B (protein): 
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1le5.pdb2.pdb:   [ download sequences in FASTA format ]
G (dna): 
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H (dna): 
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E (protein): 
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F (protein): 
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