General information
PDB ID 1NVP
Title HUMAN TFIIA/TBP/DNA COMPLEX
PDB header TRANSCRIPTION/DNA
Date 2003-02-04
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.1
Kind dna
Organism HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
 PDIdb 
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb1nvp.pdb ABCD EF 0
Biounits:
1nvp.pdb1.pdb ABCD EF 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
TBP Domain P20226_162-244 6.2e-33 1 CL0407 A 162 244 EF  S-Bb S-Mn L-Bb L-Mn 
TBP Domain P20226_252-335 9.9e-32 1 CL0407 A 252 335 EF  S-Bb S-Mn L-Bb L-Mj L-Mn 
TFIIA_gamma_N Domain P52657_3-48 8.6e-23 1 No_clan D 3 48   
TFIIA_gamma_C Domain P52657_59-99 6.8e-21 1 No_clan D 59 99   
TFIIA Family P52655_13-51 6.7e-18 1 No_clan B 13 51   
TFIIA Family P52655_330-376 1e-32 1 No_clan C 330 376 F  S-Bb L-Bb 
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: All beta proteins
  Fold: Transcription factor IIA (TFIIA), beta-barrel domain
    Superfamily: Transcription factor IIA (TFIIA), beta-barrel domain
      Family: Transcription factor IIA (TFIIA), beta-barrel domain
Large chain TOA1, C-terminal domain C N/A N/A F  S-Bb L-Bb 
Class: All beta proteins
  Fold: Transcription factor IIA (TFIIA), beta-barrel domain
    Superfamily: Transcription factor IIA (TFIIA), beta-barrel domain
      Family: Transcription factor IIA (TFIIA), beta-barrel domain
Small chain TOA2, C-terminal domain D 54 99 -
Class: Alpha and beta proteins (a+b)
  Fold: TBP-like
    Superfamily: TATA-box binding protein-like
      Family: TATA-box binding protein (TBP), C-terminal domain
TATA-box binding protein (TBP), C-terminal domain A 159 252 EF  S-Bb S-Mn L-Bb L-Mn 
Class: Alpha and beta proteins (a+b)
  Fold: TBP-like
    Superfamily: TATA-box binding protein-like
      Family: TATA-box binding protein (TBP), C-terminal domain
TATA-box binding protein (TBP), C-terminal domain A 253 338 EF  S-Bb S-Mn L-Bb L-Mn 
Class: All alpha proteins
  Fold: Transcription factor IIA (TFIIA), alpha-helical domain
    Superfamily: Transcription factor IIA (TFIIA), alpha-helical domain
      Family: Transcription factor IIA (TFIIA), alpha-helical domain
Large chain TOA1, N-terminal domain B N/A N/A -
Class: All alpha proteins
  Fold: Transcription factor IIA (TFIIA), alpha-helical domain
    Superfamily: Transcription factor IIA (TFIIA), alpha-helical domain
      Family: Transcription factor IIA (TFIIA), alpha-helical domain
Small chain TOA2, N-terminal domain D 3 53 -
GO terms
Protein chains: GO type: GO description:
A=159-339 C cytoplasm
A=159-339 C female pronucleus
A=159-339 C male pronucleus
A=159-339 C nuclear chromatin
A=159-339 C nuclear euchromatin
A=159-339 C nucleoplasm
A=159-339 C nucleus
A=159-339 C protein-containing complex
A=159-339 C transcription factor TFIIA complex
A=159-339 C transcription factor TFIID complex
A=159-339 C transcription factor TFIIIB complex
A=159-339 C transcription preinitiation complex
A=159-339 C transcription regulator complex
A=159-339 F aryl hydrocarbon receptor binding
A=159-339 F core promoter sequence-specific DNA binding
A=159-339 F DNA-binding transcription factor activity
A=159-339 F enzyme binding
A=159-339 F repressing transcription factor binding
A=159-339 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
A=159-339 F RNA polymerase II core promoter sequence-specific DNA binding
A=159-339 F RNA polymerase II general transcription initiation factor activity
A=159-339 F RNA polymerase II general transcription initiation factor binding
A=159-339 F RNA polymerase II repressing transcription factor binding
A=159-339 F RNA polymerase III general transcription initiation factor activity
A=159-339 F RNA polymerase III transcription regulatory region sequence-specific DNA binding
A=159-339 F TFIIB-class transcription factor binding
A=159-339 F transcription factor binding
A=159-339 F transcription regulatory region sequence-specific DNA binding
A=159-339 P positive regulation of gene expression, epigenetic
A=159-339 P positive regulation of transcription, DNA-templated
A=159-339 P regulation of signal transduction by p53 class mediator
A=159-339 P RNA polymerase II preinitiation complex assembly
A=159-339 P RNA polymerase III preinitiation complex assembly
A=159-339 P snRNA transcription by RNA polymerase II
A=159-339 P spermatogenesis
A=159-339 P termination of RNA polymerase I transcription
A=159-339 P transcription by RNA polymerase II
A=159-339 P transcription by RNA polymerase III
A=159-339 P transcription elongation from RNA polymerase I promoter
A=159-339 P transcription initiation from RNA polymerase I promoter
A=159-339 P transcription initiation from RNA polymerase II promoter
A=159-339 P viral process
B=2-58, C=303-376 C cytosol
B=2-58, C=303-376 C nucleoplasm
B=2-58, C=303-376 C transcription factor TFIIA complex
B=2-58, C=303-376 C transcription factor TFIID complex
B=2-58, C=303-376 C transcription preinitiation complex
B=2-58, C=303-376 F DNA binding
B=2-58, C=303-376 F protein heterodimerization activity
B=2-58, C=303-376 F RNA polymerase II core promoter sequence-specific DNA binding
B=2-58, C=303-376 F RNA polymerase II general transcription initiation factor activity
B=2-58, C=303-376 F RNA polymerase II repressing transcription factor binding
B=2-58, C=303-376 F TBP-class protein binding
B=2-58, C=303-376 F transcription factor binding
B=2-58, C=303-376 P snRNA transcription by RNA polymerase II
B=2-58, C=303-376 P transcription by RNA polymerase II
B=2-58, C=303-376 P transcription initiation from RNA polymerase II promoter
D=2-109 C cell junction
D=2-109 C nucleoplasm
D=2-109 C transcription factor TFIIA complex
D=2-109 C transcription factor TFIID complex
D=2-109 F protein heterodimerization activity
D=2-109 F protein homodimerization activity
D=2-109 F RNA polymerase II general transcription initiation factor activity
D=2-109 F RNA polymerase II repressing transcription factor binding
D=2-109 F TBP-class protein binding
D=2-109 F transcription coactivator activity
D=2-109 F transcription factor binding
D=2-109 P positive regulation of DNA-binding transcription factor activity
D=2-109 P positive regulation of transcription by RNA polymerase II
D=2-109 P RNA polymerase II preinitiation complex assembly
D=2-109 P snRNA transcription by RNA polymerase II
D=2-109 P transcription by RNA polymerase II
D=2-109 P transcription initiation from RNA polymerase II promoter
D=2-109 P viral process
Sequences
Download file with secondary structure created by Stride  
1nvp.pdb1.pdb:   [ download sequences in FASTA format ]
E (dna): 
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F (dna): 
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A (protein): 
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B (protein): 
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C (protein): 
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D (protein): 
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