General information
PDB ID 1R0A
Title CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE COVALENTLY TETHERED TO DNA TEMPLATE-PRIMER SOLVED TO 2.8 ANGSTROMS
PDB header TRANSFERASE/IMMUNE SYSTEM/DNA
Date 2003-09-19
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.8
Kind dna
Organism HUMAN IMMUNODEFICIENCY VIRUS 1, MUS MUSCULUS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb1r0a.pdb ABLH TP 0
Biounits:
1r0a.pdb1.pdb ABLH TP 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
RVT_connect Domain P03366_917-1018 2.2e-59 1 No_clan A 318 419 PT  S-Bb L-Bb 
RNase_H Domain P03366_1035-1153 5.9e-29 1 CL0219 A 436 557 PT  H-Bb L-Bb L-Mn 
RVT_thumb Domain P03366_840-903 3.6e-18 1 No_clan A 241 304 TP  H-Bb L-Bb 
RVT_connect Domain P03366_917-1018 1.4e-59 1 No_clan B 318 419   
RVT_thumb Domain P03366_840-903 4e-20 1 No_clan B 241 304   
C1-set Domain P01868_8-89 6.2e-16 1 CL0011 H 131 212   
V-set Domain 0.0000000000000023 1 CL0011 H 6 122
C1-set Domain 5e-26 1 CL0011 L 115 201
V-set Domain 2e-19 1 CL0011 L 6 107
RVT_1 Family P03366_662-833 1.4e-34 1 CL0027 A 63 234 PT  S-Bb S-Mn L-Bb 
RVT_1 Family P03366_662-833 8.2e-35 1 CL0027 B 63 234   
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: Alpha and beta proteins (a/b)
  Fold: Ribonuclease H-like motif
    Superfamily: Ribonuclease H-like
      Family: Ribonuclease H
HIV RNase H (Domain of reverse transcriptase) A 430 558 PT -
Class: Multi-domain proteins (alpha and beta)
  Fold: DNA/RNA polymerases
    Superfamily: DNA/RNA polymerases
      Family: Reverse transcriptase
HIV-1 reverse transcriptase A 1 429 PT -
Class: Multi-domain proteins (alpha and beta)
  Fold: DNA/RNA polymerases
    Superfamily: DNA/RNA polymerases
      Family: Reverse transcriptase
HIV-1 reverse transcriptase B 1 429 T -
Class: All beta proteins
  Fold: Immunoglobulin-like beta-sandwich
    Superfamily: Immunoglobulin
      Family: V set domains (antibody variable domain-like)
Immunoglobulin heavy chain variable domain, VH H 1 123 -
Class: All beta proteins
  Fold: Immunoglobulin-like beta-sandwich
    Superfamily: Immunoglobulin
      Family: C1 set domains (antibody constant domain-like)
Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma H 124 225 -
Class: All beta proteins
  Fold: Immunoglobulin-like beta-sandwich
    Superfamily: Immunoglobulin
      Family: V set domains (antibody variable domain-like)
Immunoglobulin light chain kappa variable domain, VL-kappa L 1 107 -
Class: All beta proteins
  Fold: Immunoglobulin-like beta-sandwich
    Superfamily: Immunoglobulin
      Family: C1 set domains (antibody constant domain-like)
Immunoglobulin light chain kappa constant domain, CL-kappa L 108 211 -
GO terms
Protein chains: GO type: GO description:
A=600-1157, B=600-1028 C host cell plasma membrane
A=600-1157, B=600-1028 C membrane
A=600-1157, B=600-1028 C nucleoplasm
A=600-1157, B=600-1028 C cytosol
A=600-1157, B=600-1028 C host cell cytoplasm
A=600-1157, B=600-1028 C viral capsid
A=600-1157, B=600-1028 C host cell nucleus
A=600-1157, B=600-1028 F RNA binding
A=600-1157, B=600-1028 F ribonuclease H activity
A=600-1157, B=600-1028 F structural molecule activity
A=600-1157, B=600-1028 F zinc ion binding
A=600-1157, B=600-1028 F RNA-directed DNA polymerase activity
A=600-1157, B=600-1028 F DNA binding
A=600-1157, B=600-1028 F aspartic-type endopeptidase activity
A=600-1157, B=600-1028 F exoribonuclease H activity
A=600-1157, B=600-1028 F DNA-directed DNA polymerase activity
A=600-1157, B=600-1028 P uncoating of virus
A=600-1157, B=600-1028 P nucleic acid phosphodiester bond hydrolysis
A=600-1157, B=600-1028 P proteolysis
A=600-1157, B=600-1028 P RNA-dependent DNA replication
A=600-1157, B=600-1028 P entry into host cell
A=600-1157, B=600-1028 P provirus integration
A=600-1157, B=600-1028 P viral procapsid maturation
A=600-1157, B=600-1028 P modulation by virus of host apoptosis
L=1-103 C plasma membrane
L=1-103 F antigen binding
Sequences
Download file with secondary structure created by Stride  
1r0a.pdb1.pdb:   [ download sequences in FASTA format ]
P (dna): 
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T (dna): 
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A (protein): 
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B (protein): 
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H (protein): 
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L (protein): 
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