General information
PDB ID 1RFF
Title CRYSTAL STRUCTURE OF HUMAN TYROSYL-DNA PHOSPHODIESTERASE COMPLEXED WITH VANADATE, OCTAPEPTIDE KLNYYDPR, AND TETRANUCLEOTIDE AGTT.
PDB header HYDROLASE/DNA
Date 2003-11-08
Experimental method X-RAY DIFFRACTION
Resolution (A) 1.7
Kind dna
Organism HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
 PDIdb 
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb1rff.pdb ABCE DF 0
Biounits:
1rff.pdb1.pdb AC D 1
1rff.pdb2.pdb BE F 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Tyr-DNA_phospho Family Q9NUW8_165-582 2.2e-134 1 CL0479 A 165 582 D   
Tyr-DNA_phospho Family Q9NUW8_165-582 4.5e-136 1 CL0479 B 165 582 F   
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: Alpha and beta proteins (a+b)
  Fold: Phospholipase D/nuclease
    Superfamily: Phospholipase D/nuclease
      Family: Tyrosyl-DNA phosphodiesterase TDP1
Tyrosyl-DNA phosphodiesterase TDP1 A 162 350 D -
Class: Alpha and beta proteins (a+b)
  Fold: Phospholipase D/nuclease
    Superfamily: Phospholipase D/nuclease
      Family: Tyrosyl-DNA phosphodiesterase TDP1
Tyrosyl-DNA phosphodiesterase TDP1 A 351 608 D -
Class: Alpha and beta proteins (a+b)
  Fold: Phospholipase D/nuclease
    Superfamily: Phospholipase D/nuclease
      Family: Tyrosyl-DNA phosphodiesterase TDP1
Tyrosyl-DNA phosphodiesterase TDP1 B 162 350 F -
Class: Alpha and beta proteins (a+b)
  Fold: Phospholipase D/nuclease
    Superfamily: Phospholipase D/nuclease
      Family: Tyrosyl-DNA phosphodiesterase TDP1
Tyrosyl-DNA phosphodiesterase TDP1 B 351 607 F -
GO terms
Protein chains: GO type: GO description:
A/B=149-608 C nucleus
A/B=149-608 C cytoplasm
A/B=149-608 F 3'-tyrosyl-DNA phosphodiesterase activity
A/B=149-608 F double-stranded DNA binding
A/B=149-608 F single-stranded DNA binding
A/B=149-608 F exonuclease activity
A/B=149-608 P double-strand break repair
A/B=149-608 P single strand break repair
A/B=149-608 P cell death
A/B=149-608 P nucleic acid phosphodiester bond hydrolysis
Sequences
Download file with secondary structure created by Stride  
1rff.pdb1.pdb:   [ download sequences in FASTA format ]
D (dna): 
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A (protein): 
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C (protein): 
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1rff.pdb2.pdb:   [ download sequences in FASTA format ]
F (dna): 
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B (protein): 
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E (protein): 
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