General information
PDB ID 1RR8
Title STRUCTURAL MECHANISMS OF CAMPTOTHECIN RESISTANCE BY MUTATIONS IN HUMAN TOPOISOMERASE I
PDB header ISOMERASE/DNA
Date 2003-12-08
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.6
Kind dna
Organism HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb1rr8.pdb C AB 0
Biounits:
1rr8.pdb1.pdb C AB 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Topoisom_I Domain P11387_432-635 1.4e-95 1 CL0382 C 432 725 AB  H-Bb H-Mn L-Bb 
Topoisom_I_N Family P11387_215-429 2.4e-100 1 No_clan C 215 429 AB  S-Bb S-Mj L-Bb L-Mj L-Mn 
Topo_C_assoc Family P11387_708-765 7.5e-28 1 No_clan C 628 765 A  H-Bb L-Bb 
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: Alpha and beta proteins (a+b)
  Fold: DNA breaking-rejoining enzymes
    Superfamily: DNA breaking-rejoining enzymes
      Family: Eukaryotic DNA topoisomerase I, catalytic core
Eukaryotic DNA topoisomerase I, catalytic core C 431 608 A  H-Bb L-Bb 
Class: Alpha and beta proteins (a+b)
  Fold: DNA breaking-rejoining enzymes
    Superfamily: DNA breaking-rejoining enzymes
      Family: Eukaryotic DNA topoisomerase I, catalytic core
Eukaryotic DNA topoisomerase I, catalytic core C 708 765 A  H-Bb 
Class: Alpha and beta proteins (a+b)
  Fold: DNA breaking-rejoining enzymes
    Superfamily: DNA breaking-rejoining enzymes
      Family: Eukaryotic DNA topoisomerase I, catalytic core
Eukaryotic DNA topoisomerase I, catalytic core C 431 608 AB  H-Bb L-Bb 
Class: Alpha and beta proteins (a+b)
  Fold: DNA breaking-rejoining enzymes
    Superfamily: DNA breaking-rejoining enzymes
      Family: Eukaryotic DNA topoisomerase I, catalytic core
Eukaryotic DNA topoisomerase I, catalytic core C 708 765 AB  H-Bb 
Class: Multi-domain proteins (alpha and beta)
  Fold: Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment
    Superfamily: Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment
      Family: Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment C 201 430 AB  S-Bb S-Mj L-Bb L-Mj 
GO terms
Protein chains: GO type: GO description:
C=203-765 C nucleoplasm
C=203-765 C nucleolus
C=203-765 C replication fork protection complex
C=203-765 C perikaryon
C=203-765 C cytoplasmic mRNA processing body
C=203-765 F DNA topoisomerase (ATP-hydrolyzing) activity
C=203-765 F DNA topoisomerase type I activity
C=203-765 F ATP binding
C=203-765 F chromatin binding
C=203-765 P chromatin remodeling
C=203-765 P chromosome segregation
C=203-765 P embryonic cleavage
C=203-765 P DNA topological change
C=203-765 P phosphorylation
C=203-765 P virus-host interaction
C=203-765 P programmed cell death
C=203-765 P response to drug
C=203-765 P DNA replication
Sequences
Download file with secondary structure created by Stride  
1rr8.pdb1.pdb:   [ download sequences in FASTA format ]
A (dna): 
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B (dna): 
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C (protein): 
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