General information
PDB ID 1S9K
Title CRYSTAL STRUCTURE OF HUMAN NFAT1 AND FOS-JUN ON THE IL-2 ARRE1 SITE
PDB header TRANSCRIPTION/DNA
Date 2004-02-04
Experimental method X-RAY DIFFRACTION
Resolution (A) 3.1
Kind dna
Organism HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb1s9k.pdb CDE AB 0
Biounits:
1s9k.pdb1.pdb CDE AB 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
RHD_dimer Domain Q13469_579-678 6.2e-26 1 CL0159 C 579 678   
RHD_DNA_bind Domain Q13469_410-570 4.5e-23 1 CL0073 C 410 570 AB  H-Bb S-Bb L-Bb L-Mj 
bZIP_1 Family P01100_140-192 0.000000018 1 CL0018 D 140 192 AB  H-Bb H-Mj 
bZIP_1 Family P05412_257-308 8.2e-16 1 CL0018 E 267 318 AB  H-Bb H-Mj L-Bb 
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: All beta proteins
  Fold: Immunoglobulin-like beta-sandwich
    Superfamily: E set domains
      Family: NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain
T-cell transcription factor NFAT1 (NFATC2) C 576 678 -
Class: All beta proteins
  Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f
    Superfamily: p53-like transcription factors
      Family: Rel/Dorsal transcription factors, DNA-binding domain
T-cell transcription factor NFAT1 (NFATC), DNA-binding domain C 399 575 AB  H-Bb H-Mj S-Bb L-Bb L-Mj 
Class: Coiled coil proteins
  Fold: Parallel coiled-coil
    Superfamily: Leucine zipper domain
      Family: Leucine zipper domain
C-fos D 140 192 AB  H-Bb H-Mj 
Class: Coiled coil proteins
  Fold: Parallel coiled-coil
    Superfamily: Leucine zipper domain
      Family: Leucine zipper domain
C-jun E 267 318 AB  H-Bb H-Mj 
GO terms
Protein chains: GO type: GO description:
C=399-678 C cytosol
C=399-678 C ribonucleoprotein complex
C=399-678 C nucleus
C=399-678 C plasma membrane
C=399-678 C actin cytoskeleton
C=399-678 F DNA binding
C=399-678 P transcription, DNA-dependent
C=399-678 P response to DNA damage stimulus
C=399-678 P cytokine production
C=399-678 P B cell receptor signaling pathway
C=399-678 P response to drug
C=399-678 P positive regulation of B cell proliferation
C=399-678 P positive regulation of transcription from RNA polymerase II promoter
D=140-192 C nucleoplasm
D=140-192 F transcription regulatory region DNA binding
D=140-192 F sequence-specific DNA binding transcription factor activity
D=140-192 F sequence-specific DNA binding
D=140-192 P innate immune response
D=140-192 P stress-activated MAPK cascade
D=140-192 P DNA methylation
D=140-192 P transcription from RNA polymerase II promoter
D=140-192 P toll-like receptor 1 signaling pathway
D=140-192 P transforming growth factor beta receptor signaling pathway
D=140-192 P positive regulation of transcription, DNA-dependent
D=140-192 P toll-like receptor 4 signaling pathway
D=140-192 P toll-like receptor 2 signaling pathway
D=140-192 P Toll signaling pathway
D=140-192 P SMAD protein signal transduction
D=140-192 P MyD88-dependent toll-like receptor signaling pathway
D=140-192 P regulation of transcription from RNA polymerase II promoter
D=140-192 P regulation of sequence-specific DNA binding transcription factor activity
D=140-192 P inflammatory response
D=140-192 P TRIF-dependent toll-like receptor signaling pathway
D=140-192 P cellular response to reactive oxygen species
D=140-192 P toll-like receptor 3 signaling pathway
E=257-308 C nuclear euchromatin
E=257-308 C transcriptional repressor complex
E=257-308 C transcription factor complex
E=257-308 F Rho GTPase activator activity
E=257-308 F RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
E=257-308 F RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
E=257-308 F RNA polymerase II distal enhancer sequence-specific DNA binding
E=257-308 F double-stranded DNA binding
E=257-308 F cAMP response element binding
E=257-308 F transcription coactivator activity
E=257-308 P positive regulation of DNA replication
E=257-308 P positive regulation of smooth muscle cell proliferation
E=257-308 P positive regulation by host of viral transcription
E=257-308 P response to lipopolysaccharide
E=257-308 P positive regulation of endothelial cell proliferation
E=257-308 P aging
E=257-308 P response to cAMP
E=257-308 P learning
E=257-308 P negative regulation of cell proliferation
E=257-308 P negative regulation of DNA binding
E=257-308 P negative regulation of neuron apoptotic process
E=257-308 P cellular response to calcium ion
E=257-308 P response to radiation
E=257-308 P positive regulation of monocyte differentiation
E=257-308 P monocyte differentiation
E=257-308 P SMAD protein import into nucleus
E=257-308 P membrane depolarization
E=257-308 P leading edge cell differentiation
E=257-308 P negative regulation by host of viral transcription
E=257-308 P negative regulation of protein autophosphorylation
E=257-308 P liver development
E=257-308 P negative regulation of transcription, DNA-dependent
E=257-308 P response to cytokine stimulus
E=257-308 P positive regulation of fibroblast proliferation
E=257-308 P circadian rhythm
E=257-308 P regulation of cell cycle
E=257-308 P response to organic cyclic compound
E=257-308 P response to hydrogen peroxide
E=257-308 P cellular response to potassium ion starvation
E=257-308 P axon regeneration
E=257-308 P release of cytochrome c from mitochondria
E=257-308 P response to mechanical stimulus
E=257-308 P positive regulation of neuron apoptotic process
E=257-308 P angiogenesis
E=257-308 P outflow tract morphogenesis
E=257-308 P microglial cell activation
Sequences
Download file with secondary structure created by Stride  
1s9k.pdb1.pdb:   [ download sequences in FASTA format ]
A (dna): 
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B (dna): 
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C (protein): 
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D (protein): 
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E (protein): 
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