General information
PDB ID 1SVC
Title NFKB P50 HOMODIMER BOUND TO DNA
PDB header TRANSCRIPTION/DNA
Date 1995-11-27
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.6
Kind dna
Organism HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb1svc.pdb P D 0
Biounits:
1svc.pdb1.pdb PB DA 0
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
RHD_DNA_bind Domain 2e-72 1 CL0073 B 45 243 AD
RHD_dimer Domain 6.3e-42 1 CL0159 B 252 353 A
RHD_DNA_bind Domain P19838_44-242 2e-72 1 CL0073 P 45 243 AD   
RHD_dimer Domain P19838_251-352 6.3e-42 1 CL0159 P 252 353 D   
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: All beta proteins
  Fold: Immunoglobulin-like beta-sandwich
    Superfamily: E set domains
      Family: NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain
p50 subunit of NF-kappa B transcription factor P 251 353 D  L-Bb 
Class: All beta proteins
  Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f
    Superfamily: p53-like transcription factors
      Family: Rel/Dorsal transcription factors, DNA-binding domain
p50 subunit of NF-kappa B (NFKB), N-terminal domain P 43 250 AD  H-Bb H-Mj S-Bb S-Mj L-Mj 
GO terms
Protein chains: GO type: GO description:
P=2-365 C I-kappaB/NF-kappaB complex
P=2-365 C nucleoplasm
P=2-365 C cytosol
P=2-365 C mitochondrion
P=2-365 F double-stranded DNA binding
P=2-365 F sequence-specific DNA binding transcription factor activity
P=2-365 F transcription regulatory region sequence-specific DNA binding
P=2-365 P negative regulation of calcidiol 1-monooxygenase activity
P=2-365 P membrane protein intracellular domain proteolysis
P=2-365 P apoptotic process
P=2-365 P negative regulation of transcription from RNA polymerase II promoter
P=2-365 P Toll signaling pathway
P=2-365 P positive regulation of transcription, DNA-dependent
P=2-365 P T cell receptor signaling pathway
P=2-365 P positive regulation of hyaluronan biosynthetic process
P=2-365 P MyD88-dependent toll-like receptor signaling pathway
P=2-365 P positive regulation of lipid storage
P=2-365 P toll-like receptor 4 signaling pathway
P=2-365 P cellular response to interleukin-1
P=2-365 P TRIF-dependent toll-like receptor signaling pathway
P=2-365 P negative regulation of cytokine production
P=2-365 P positive regulation of transcription from RNA polymerase II promoter
P=2-365 P negative regulation of interleukin-12 biosynthetic process
P=2-365 P negative regulation of vitamin D biosynthetic process
P=2-365 P response to copper ion
P=2-365 P innate immune response
P=2-365 P anti-apoptosis
P=2-365 P toll-like receptor 3 signaling pathway
P=2-365 P positive regulation of macrophage derived foam cell differentiation
P=2-365 P positive regulation of canonical Wnt receptor signaling pathway
P=2-365 P inflammatory response
P=2-365 P cellular response to mechanical stimulus
P=2-365 P transcription from RNA polymerase II promoter
P=2-365 P toll-like receptor 1 signaling pathway
P=2-365 P toll-like receptor 2 signaling pathway
P=2-365 P negative regulation of cholesterol transport
P=2-365 P negative regulation of cellular protein metabolic process
P=2-365 P nerve growth factor receptor signaling pathway
P=2-365 P response to oxidative stress
P=2-365 P response to bacterium
P=2-365 P positive regulation of type I interferon production
P=2-365 P positive regulation of NF-kappaB transcription factor activity
Sequences
Download file with secondary structure created by Stride  
1svc.pdb1.pdb:   [ download sequences in FASTA format ]
A (dna): 
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D (dna): 
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B (protein): 
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P (protein): 
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