General information
PDB ID 1T03
Title HIV-1 REVERSE TRANSCRIPTASE CROSSLINKED TO TENOFOVIR TERMINATED TEMPLATE-PRIMER (COMPLEX P)
PDB header TRANSFERASE/ANTIBODY/DNA
Date 2004-04-07
Experimental method X-RAY DIFFRACTION
Resolution (A) 3.1
Kind dna
Organism HUMAN IMMUNODEFICIENCY VIRUS 1, MUS MUSCULUS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb1t03.pdb ABLH TP 0
Biounits:
1t03.pdb1.pdb ABLH TP 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
RVT_connect Domain P03366_917-1018 2.5e-59 1 No_clan A 318 419 PT  S-Bb L-Bb 
RVT_1 Domain P03366_662-833 1.1e-34 1 CL0027 A 63 234 PT  S-Bb S-Mn L-Bb 
RNase_H Domain P03366_1035-1153 5.5e-29 1 CL0219 A 436 557 PT  H-Bb L-Bb L-Mn 
RVT_thumb Domain P03366_840-903 1.1e-19 1 No_clan A 241 304 TP  H-Bb L-Bb 
RVT_connect Domain P03366_917-1018 1.6e-59 1 No_clan B 318 419   
RVT_1 Domain P03366_662-833 6.7e-35 1 CL0027 B 63 234   
RVT_thumb Domain P03366_840-903 1.5e-21 1 No_clan B 241 304   
C1-set Domain 3.4e-16 1 CL0011 H 131 212
V-set Domain 1.3e-14 1 CL0011 H 6 122
C1-set Domain P01837_116-202 2.8e-26 1 CL0011 L 115 201   
V-set Domain P01837_7-112 9.5e-19 1 CL0011 L 6 107   
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: Alpha and beta proteins (a/b)
  Fold: Ribonuclease H-like motif
    Superfamily: Ribonuclease H-like
      Family: Ribonuclease H
HIV RNase H (Domain of reverse transcriptase) A 430 558 PT -
Class: Multi-domain proteins (alpha and beta)
  Fold: DNA/RNA polymerases
    Superfamily: DNA/RNA polymerases
      Family: Reverse transcriptase
HIV-1 reverse transcriptase A 1 429 PT -
Class: Multi-domain proteins (alpha and beta)
  Fold: DNA/RNA polymerases
    Superfamily: DNA/RNA polymerases
      Family: Reverse transcriptase
HIV-1 reverse transcriptase B N/A N/A T -
Class: All beta proteins
  Fold: Immunoglobulin-like beta-sandwich
    Superfamily: Immunoglobulin
      Family: V set domains (antibody variable domain-like)
Immunoglobulin heavy chain variable domain, VH H 1 123 -
Class: All beta proteins
  Fold: Immunoglobulin-like beta-sandwich
    Superfamily: Immunoglobulin
      Family: C1 set domains (antibody constant domain-like)
Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma H 124 225 -
Class: All beta proteins
  Fold: Immunoglobulin-like beta-sandwich
    Superfamily: Immunoglobulin
      Family: V set domains (antibody variable domain-like)
Immunoglobulin light chain kappa variable domain, VL-kappa L 1 107 -
Class: All beta proteins
  Fold: Immunoglobulin-like beta-sandwich
    Superfamily: Immunoglobulin
      Family: C1 set domains (antibody constant domain-like)
Immunoglobulin light chain kappa constant domain, CL-kappa L 108 211 -
GO terms
Protein chains: GO type: GO description:
A=600-1157, B=600-1028 C host cell nucleus
A=600-1157, B=600-1028 C host cell plasma membrane
A=600-1157, B=600-1028 C host multivesicular body
A=600-1157, B=600-1028 C viral nucleocapsid
A=600-1157, B=600-1028 C virion membrane
A=600-1157, B=600-1028 F aspartic-type endopeptidase activity
A=600-1157, B=600-1028 F DNA binding
A=600-1157, B=600-1028 F DNA-directed DNA polymerase activity
A=600-1157, B=600-1028 F exoribonuclease H activity
A=600-1157, B=600-1028 F lipid binding
A=600-1157, B=600-1028 F RNA binding
A=600-1157, B=600-1028 F RNA-directed DNA polymerase activity
A=600-1157, B=600-1028 F RNA-DNA hybrid ribonuclease activity
A=600-1157, B=600-1028 F structural molecule activity
A=600-1157, B=600-1028 F zinc ion binding
A=600-1157, B=600-1028 P DNA integration
A=600-1157, B=600-1028 P DNA recombination
A=600-1157, B=600-1028 P establishment of integrated proviral latency
A=600-1157, B=600-1028 P induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process
A=600-1157, B=600-1028 P suppression by virus of host gene expression
A=600-1157, B=600-1028 P viral entry into host cell
A=600-1157, B=600-1028 P viral genome integration into host DNA
A=600-1157, B=600-1028 P viral penetration into host nucleus
L=1-104 C external side of plasma membrane
L=1-104 C immunoglobulin complex, circulating
L=1-104 C plasma membrane
L=1-104 F antigen binding
L=1-104 F immunoglobulin receptor binding
L=1-104 P B cell differentiation
L=1-104 P B cell receptor signaling pathway
L=1-104 P complement activation, classical pathway
L=1-104 P defense response to bacterium
L=1-104 P innate immune response
L=1-104 P phagocytosis, engulfment
L=1-104 P phagocytosis, recognition
L=1-104 P positive regulation of B cell activation
Sequences
Download file with secondary structure created by Stride  
1t03.pdb1.pdb:   [ download sequences in FASTA format ]
P (dna): 
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T (dna): 
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A (protein): 
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B (protein): 
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H (protein): 
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L (protein): 
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