General information
PDB ID 1T2K
Title STRUCTURE OF THE DNA BINDING DOMAINS OF IRF3, ATF-2 AND JUN BOUND TO DNA
PDB header TRANSCRIPTION/DNA
Date 2004-04-21
Experimental method X-RAY DIFFRACTION
Resolution (A) 3
Kind dna
Organism HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb1t2k.pdb ABCD EF 0
Biounits:
1t2k.pdb1.pdb ABCD EF 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
IRF Domain Q14653_7-110 4e-36 1 CL0123 A 7 110 EF  H-Bb H-Mj L-Bb L-Mn 
IRF Domain Q14653_7-110 3.7e-36 1 CL0123 B 7 110 EF  H-Bb H-Mj L-Bb L-Mn 
bZIP_1 Family P05412_257-313 4.7e-18 1 CL0018 C 253 313 E  H-Bb H-Mj 
PspA_IM30 Family 0.00042 0 CL0235 C 271 314
ZapB Family 0.00045 0 No_clan C 267 313
bZIP_1 Family P15336_354-413 0.00000000000048 1 CL0018 D 336 395 EF  H-Bb H-Mj 
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: All alpha proteins
  Fold: DNA/RNA-binding 3-helical bundle
    Superfamily: "Winged helix" DNA-binding domain
      Family: Interferon regulatory factor
Interferon regulatory factor 3, IRF-3 A N/A N/A EF  H-Bb H-Mj L-Bb 
Class: All alpha proteins
  Fold: DNA/RNA-binding 3-helical bundle
    Superfamily: "Winged helix" DNA-binding domain
      Family: Interferon regulatory factor
Interferon regulatory factor 3, IRF-3 B N/A N/A EF  H-Bb H-Mj L-Bb 
Class: Coiled coil proteins
  Fold: Parallel coiled-coil
    Superfamily: Leucine zipper domain
      Family: Leucine zipper domain
C-jun C N/A N/A E  H-Bb H-Mj 
Class: Coiled coil proteins
  Fold: Parallel coiled-coil
    Superfamily: Leucine zipper domain
      Family: Leucine zipper domain
Cyclic-AMP-dependent transcription factor ATF-2 D N/A N/A EF  H-Bb H-Mj 
GO terms
Protein chains: GO type: GO description:
A/B=1-112 C plasma membrane
A/B=1-112 C endosome membrane
A/B=1-112 F DNA binding
A/B=1-112 F sequence-specific DNA binding transcription factor activity
A/B=1-112 F transcription cofactor activity
A/B=1-112 F transcription regulatory region DNA binding
A/B=1-112 P type I interferon-mediated signaling pathway
A/B=1-112 P type I interferon biosynthetic process
A/B=1-112 P interferon-gamma-mediated signaling pathway
A/B=1-112 P positive regulation of cytokine secretion
A/B=1-112 P cellular response to dsRNA
A/B=1-112 P lipopolysaccharide-mediated signaling pathway
A/B=1-112 P negative regulation of type I interferon production
A/B=1-112 P induction of apoptosis
A/B=1-112 P virus-host interaction
A/B=1-112 P negative regulation of transcription from RNA polymerase II promoter
A/B=1-112 P positive regulation of interferon-alpha production
A/B=1-112 P macrophage apoptotic process
A/B=1-112 P negative regulation of interferon-beta biosynthetic process
A/B=1-112 P positive regulation of I-kappaB kinase/NF-kappaB cascade
A/B=1-112 P response to exogenous dsRNA
A/B=1-112 P positive regulation of interferon-beta production
A/B=1-112 P MDA-5 signaling pathway
A/B=1-112 P negative regulation of defense response to virus by host
A/B=1-112 P response to DNA damage stimulus
A/B=1-112 P transcription from RNA polymerase II promoter
C=254-314 C nuclear euchromatin
C=254-314 C transcription factor complex
C=254-314 C nucleoplasm
C=254-314 C cytosol
C=254-314 C transcriptional repressor complex
C=254-314 F transcription coactivator activity
C=254-314 F double-stranded DNA binding
C=254-314 F Rho GTPase activator activity
C=254-314 F cAMP response element binding
C=254-314 F RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
C=254-314 F RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
C=254-314 F RNA polymerase II distal enhancer sequence-specific DNA binding
C=254-314 P positive regulation of fibroblast proliferation
C=254-314 P regulation of sequence-specific DNA binding transcription factor activity
C=254-314 P response to mechanical stimulus
C=254-314 P aging
C=254-314 P release of cytochrome c from mitochondria
C=254-314 P axon regeneration
C=254-314 P positive regulation of monocyte differentiation
C=254-314 P negative regulation of transcription, DNA-dependent
C=254-314 P outflow tract morphogenesis
C=254-314 P regulation of cell cycle
C=254-314 P response to drug
C=254-314 P toll-like receptor 3 signaling pathway
C=254-314 P positive regulation by host of viral transcription
C=254-314 P negative regulation of neuron apoptotic process
C=254-314 P microglial cell activation
C=254-314 P SMAD protein import into nucleus
C=254-314 P toll-like receptor 1 signaling pathway
C=254-314 P response to cytokine stimulus
C=254-314 P response to cAMP
C=254-314 P toll-like receptor 2 signaling pathway
C=254-314 P cellular response to calcium ion
C=254-314 P response to organic cyclic compound
C=254-314 P positive regulation of smooth muscle cell proliferation
C=254-314 P angiogenesis
C=254-314 P positive regulation of neuron apoptotic process
C=254-314 P transforming growth factor beta receptor signaling pathway
C=254-314 P membrane depolarization
C=254-314 P circadian rhythm
C=254-314 P response to hydrogen peroxide
C=254-314 P Toll signaling pathway
C=254-314 P liver development
C=254-314 P negative regulation of protein autophosphorylation
C=254-314 P stress-activated MAPK cascade
C=254-314 P toll-like receptor 4 signaling pathway
C=254-314 P innate immune response
C=254-314 P negative regulation by host of viral transcription
C=254-314 P response to radiation
C=254-314 P MyD88-dependent toll-like receptor signaling pathway
C=254-314 P positive regulation of DNA replication
C=254-314 P monocyte differentiation
C=254-314 P negative regulation of cell proliferation
C=254-314 P learning
C=254-314 P leading edge cell differentiation
C=254-314 P positive regulation of endothelial cell proliferation
C=254-314 P response to lipopolysaccharide
C=254-314 P SMAD protein signal transduction
C=254-314 P cellular response to potassium ion starvation
C=254-314 P negative regulation of DNA binding
C=254-314 P TRIF-dependent toll-like receptor signaling pathway
D=354-414 C membrane fraction
D=354-414 F RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
D=354-414 F cAMP response element binding protein binding
D=354-414 F RNA polymerase II transcription factor binding transcription factor activity
D=354-414 F chromatin binding
D=354-414 F zinc ion binding
D=354-414 P fat cell differentiation
D=354-414 P adipose tissue development
D=354-414 P positive regulation of transforming growth factor beta2 production
D=354-414 P response to osmotic stress
Sequences
Download file with secondary structure created by Stride  
1t2k.pdb1.pdb:   [ download sequences in FASTA format ]
E (dna): 
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F (dna): 
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A (protein): 
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B (protein): 
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C (protein): 
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D (protein): 
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