General information
PDB ID 1TL8
Title HUMAN DNA TOPOISOMERASE I (70 KDA) IN COMPLEX WITH THE INDENOISOQUINOLINE AI-III-52 AND COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX
PDB header ISOMERASE/DNA
Date 2004-06-09
Experimental method X-RAY DIFFRACTION
Resolution (A) 3.1
Kind dna
Organism HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb1tl8.pdb A BCD 0
Biounits:
1tl8.pdb1.pdb A BCD 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Topoisom_I Domain P11387_432-665 8.5e-103 1 CL0382 A 432 665 BCD  L-Bb 
Topoisom_I_N Family P11387_215-429 1.4e-101 1 No_clan A 215 429 BD   
Topo_C_assoc Family P11387_695-765 5.2e-31 1 No_clan A 695 765 B   
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: All alpha proteins
  Fold: Long alpha-hairpin
    Superfamily: Eukaryotic DNA topoisomerase I, dispensable insert domain
      Family: Eukaryotic DNA topoisomerase I, dispensable insert domain
Eukaryotic DNA topoisomerase I, dispensable insert domain A 636 712 -
Class: Alpha and beta proteins (a+b)
  Fold: DNA breaking-rejoining enzymes
    Superfamily: DNA breaking-rejoining enzymes
      Family: Eukaryotic DNA topoisomerase I, catalytic core
Eukaryotic DNA topoisomerase I, catalytic core A 431 633 B  H-Bb L-Bb 
Class: Alpha and beta proteins (a+b)
  Fold: DNA breaking-rejoining enzymes
    Superfamily: DNA breaking-rejoining enzymes
      Family: Eukaryotic DNA topoisomerase I, catalytic core
Eukaryotic DNA topoisomerase I, catalytic core A 714 765 B -
Class: Alpha and beta proteins (a+b)
  Fold: DNA breaking-rejoining enzymes
    Superfamily: DNA breaking-rejoining enzymes
      Family: Eukaryotic DNA topoisomerase I, catalytic core
Eukaryotic DNA topoisomerase I, catalytic core A 431 633 BD  H-Bb L-Bb 
Class: Alpha and beta proteins (a+b)
  Fold: DNA breaking-rejoining enzymes
    Superfamily: DNA breaking-rejoining enzymes
      Family: Eukaryotic DNA topoisomerase I, catalytic core
Eukaryotic DNA topoisomerase I, catalytic core A 714 765 BD -
Class: Multi-domain proteins (alpha and beta)
  Fold: Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment
    Superfamily: Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment
      Family: Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment A 201 430 BD  S-Bb S-Mj L-Bb 
GO terms
Protein chains: GO type: GO description:
A=174-765 C perikaryon
A=174-765 C cytoplasmic mRNA processing body
A=174-765 C replication fork protection complex
A=174-765 C nucleoplasm
A=174-765 C nucleolus
A=174-765 F DNA topoisomerase type I activity
A=174-765 F DNA topoisomerase (ATP-hydrolyzing) activity
A=174-765 F ATP binding
A=174-765 F chromatin binding
A=174-765 P response to drug
A=174-765 P programmed cell death
A=174-765 P DNA topological change
A=174-765 P embryonic cleavage
A=174-765 P virus-host interaction
A=174-765 P DNA replication
A=174-765 P chromatin remodeling
A=174-765 P chromosome segregation
A=174-765 P phosphorylation
Sequences
Download file with secondary structure created by Stride  
1tl8.pdb1.pdb:   [ download sequences in FASTA format ]
B (dna): 
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C (dna): 
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D (dna): 
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A (protein): 
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