General information
PDB ID 1U35
Title CRYSTAL STRUCTURE OF THE NUCLEOSOME CORE PARTICLE CONTAINING THE HISTONE DOMAIN OF MACROH2A
PDB header STRUCTURAL PROTEIN/DNA
Date 2004-07-20
Experimental method X-RAY DIFFRACTION
Resolution (A) 3
Kind dna
Organism HOMO SAPIENS, MUS MUSCULUS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb1u35.pdb ABCDEFGH IJ 0
Biounits:
1u35.pdb1.pdb ABCDEFGH IJ 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Histone Domain P68433_39-132 1.1e-46 1 CL0012 A 438 531 IJ  H-Bb H-Mj S-Bb S-Mn L-Bb L-Mn 
CENP-T_C Domain P62806_24-99 4.4e-08 1 CL0012 B 26 98 IJ  H-Bb S-Bb L-Bb 
Histone Domain O75367_12-88 2.6e-13 1 CL0012 C 814 890 IJ  H-Bb S-Bb S-Mn L-Bb L-Mn 
Histone Domain Q9D2U9_31-102 1.4e-21 1 CL0012 D 1230 1298 IJ  H-Bb H-Mj S-Bb L-Bb 
Histone Domain P68433_39-132 1.1e-46 1 CL0012 E 638 731 IJ  H-Bb H-Mj S-Bb L-Bb L-Mn 
CENP-T_C Domain P62806_24-99 4.9e-08 1 CL0012 F 225 298 IJ  H-Bb S-Bb L-Bb 
Histone Domain O75367_12-88 2.6e-13 1 CL0012 G 1014 1090 IJ  H-Bb S-Bb S-Mn L-Bb L-Mn 
Histone Domain Q9D2U9_31-102 6.5e-22 1 CL0012 H 1427 1498 IJ  H-Bb H-Mj S-Bb L-Bb 
Histone_H2A_C Family O75367_89-117 3.3e-17 1 No_clan C 891 919   
Histone_H2A_C Family O75367_89-117 3.3e-17 1 No_clan G 1091 1119   
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: All alpha proteins
  Fold: Histone-fold
    Superfamily: Histone-fold
      Family: Nucleosome core histones
macro-H2A.1, histone domain C 814 919 IJ  H-Bb S-Bb S-Mn L-Bb 
Class: All alpha proteins
  Fold: Histone-fold
    Superfamily: Histone-fold
      Family: Nucleosome core histones
macro-H2A.1, histone domain G 1014 1119 IJ  H-Bb S-Bb S-Mn L-Bb 
Class: All alpha proteins
  Fold: Histone-fold
    Superfamily: Histone-fold
      Family: Nucleosome core histones
Histone H3 A 438 535 IJ  H-Bb H-Mj S-Bb S-Mn L-Bb L-Mn 
Class: All alpha proteins
  Fold: Histone-fold
    Superfamily: Histone-fold
      Family: Nucleosome core histones
Histone H3 E 638 735 IJ  H-Bb H-Mj S-Bb L-Bb L-Mn 
Class: All alpha proteins
  Fold: Histone-fold
    Superfamily: Histone-fold
      Family: Nucleosome core histones
Histone H4 B 24 102 IJ  H-Bb S-Bb L-Bb 
Class: All alpha proteins
  Fold: Histone-fold
    Superfamily: Histone-fold
      Family: Nucleosome core histones
Histone H4 F 224 302 IJ  H-Bb S-Bb L-Bb 
Class: All alpha proteins
  Fold: Histone-fold
    Superfamily: Histone-fold
      Family: Nucleosome core histones
Histone H2B D 1230 1322 IJ  H-Bb S-Bb L-Bb 
Class: All alpha proteins
  Fold: Histone-fold
    Superfamily: Histone-fold
      Family: Nucleosome core histones
Histone H2B H 1430 1522 IJ  H-Bb H-Mj S-Bb L-Bb 
GO terms
Protein chains: GO type: GO description:
A/E=1-136 C nuclear chromosome
A/E=1-136 C nuclear nucleosome
A/E=1-136 C nucleoplasm
A/E=1-136 C nucleosome
A/E=1-136 C nucleus
A/E=1-136 C protein-containing complex
A/E=1-136 F DNA binding
A/E=1-136 F protein heterodimerization activity
A/E=1-136 P DNA replication-dependent nucleosome assembly
A/E=1-136 P nucleosome assembly
A/E=1-136 P regulation of gene silencing
B/F=1-103 C host cell nucleus
B/F=1-103 C nuclear chromosome
B/F=1-103 C nuclear nucleosome
B/F=1-103 C nucleoplasm
B/F=1-103 C nucleosome
B/F=1-103 C nucleus
B/F=1-103 C protein-containing complex
B/F=1-103 F DNA binding
B/F=1-103 F protein domain specific binding
B/F=1-103 F protein heterodimerization activity
B/F=1-103 P DNA replication-dependent nucleosome assembly
B/F=1-103 P DNA replication-independent nucleosome assembly
B/F=1-103 P DNA-templated transcription, initiation
B/F=1-103 P negative regulation of megakaryocyte differentiation
B/F=1-103 P nucleosome assembly
C/G=1-120 C Barr body
C/G=1-120 C condensed chromosome
C/G=1-120 C extracellular exosome
C/G=1-120 C nuclear chromatin
C/G=1-120 C nuclear chromosome
C/G=1-120 C nuclear chromosome, telomeric region
C/G=1-120 C nucleolus
C/G=1-120 C nucleoplasm
C/G=1-120 C nucleosome
C/G=1-120 C nucleus
C/G=1-120 C pericentric heterochromatin
C/G=1-120 C sex chromatin
C/G=1-120 F chromatin DNA binding
C/G=1-120 F DNA binding
C/G=1-120 F double-stranded methylated DNA binding
C/G=1-120 F enzyme binding
C/G=1-120 F nucleosomal DNA binding
C/G=1-120 F promoter-specific chromatin binding
C/G=1-120 F protein heterodimerization activity
C/G=1-120 F protein kinase binding
C/G=1-120 F protein serine/threonine kinase inhibitor activity
C/G=1-120 F rDNA binding
C/G=1-120 F RNA polymerase II core promoter sequence-specific DNA binding
C/G=1-120 F RNA polymerase II transcription regulatory region sequence-specific DNA binding
C/G=1-120 F transcription regulatory region sequence-specific DNA binding
C/G=1-120 P chromatin organization
C/G=1-120 P chromatin silencing
C/G=1-120 P dosage compensation
C/G=1-120 P establishment of protein localization to chromatin
C/G=1-120 P negative regulation of cell cycle G2/M phase transition
C/G=1-120 P negative regulation of gene expression, epigenetic
C/G=1-120 P negative regulation of histone H3-K27 methylation
C/G=1-120 P negative regulation of histone H3-K4 methylation
C/G=1-120 P negative regulation of histone phosphorylation
C/G=1-120 P negative regulation of protein localization to chromosome, telomeric region
C/G=1-120 P negative regulation of protein serine/threonine kinase activity
C/G=1-120 P negative regulation of response to oxidative stress
C/G=1-120 P negative regulation of transcription by RNA polymerase II
C/G=1-120 P negative regulation of transcription of nucleolar large rRNA by RNA polymerase I
C/G=1-120 P nucleosome assembly
C/G=1-120 P positive regulation of endodermal cell differentiation
C/G=1-120 P positive regulation of gene expression, epigenetic
C/G=1-120 P positive regulation of keratinocyte differentiation
C/G=1-120 P positive regulation of maintenance of mitotic sister chromatid cohesion
C/G=1-120 P positive regulation of response to oxidative stress
C/G=1-120 P regulation of gene expression, epigenetic
C/G=1-120 P regulation of lipid metabolic process
C/G=1-120 P regulation of response to oxidative stress
D/H=1-126 C cytosol
D/H=1-126 C nucleoplasm
D/H=1-126 C nucleosome
D/H=1-126 C nucleus
D/H=1-126 F DNA binding
D/H=1-126 F protein heterodimerization activity
D/H=1-126 P nucleosome assembly
Sequences
Download file with secondary structure created by Stride  
1u35.pdb1.pdb:   [ download sequences in FASTA format ]
I (dna): 
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J (dna): 
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A (protein): 
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B (protein): 
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C (protein): 
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D (protein): 
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E (protein): 
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F (protein): 
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G (protein): 
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H (protein): 
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