General information
PDB ID 2AC0
Title STRUCTURAL BASIS OF DNA RECOGNITION BY P53 TETRAMERS (COMPLEX I)
PDB header APOPTOSIS/DNA
Date 2005-07-18
Experimental method X-RAY DIFFRACTION
Resolution (A) 1.8
Kind dna
Organism HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
 PDIdb 
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb2ac0.pdb ABCD EFGH 0
Biounits:
2ac0.pdb1.pdb ABCD EFGH 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
P53 Domain P04637_99-289 4.3e-116 1 CL0073 A 95 289 EFG  H-Mj S-Bb L-Bb L-Mj 
P53 Domain P04637_99-289 4.3e-116 1 CL0073 B 95 289 EF  H-Mj S-Bb L-Bb L-Mj 
P53 Domain P04637_99-289 9.2e-116 1 CL0073 C 96 289 FGH  H-Mj S-Bb L-Bb L-Mj 
P53 Domain P04637_99-289 9.8e-116 1 CL0073 D 96 289 GH  H-Mj S-Bb L-Bb L-Mj 
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: All beta proteins
  Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f
    Superfamily: p53-like transcription factors
      Family: p53 DNA-binding domain-like
p53 tumor suppressor, DNA-binding domain A 96 289 EFG  H-Mj S-Bb L-Bb L-Mj 
Class: All beta proteins
  Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f
    Superfamily: p53-like transcription factors
      Family: p53 DNA-binding domain-like
p53 tumor suppressor, DNA-binding domain B 96 289 EF  H-Mj S-Bb L-Bb L-Mj 
Class: All beta proteins
  Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f
    Superfamily: p53-like transcription factors
      Family: p53 DNA-binding domain-like
p53 tumor suppressor, DNA-binding domain C 96 289 FGH  H-Mj S-Bb L-Bb L-Mj 
Class: All beta proteins
  Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f
    Superfamily: p53-like transcription factors
      Family: p53 DNA-binding domain-like
p53 tumor suppressor, DNA-binding domain D 96 289 GH  H-Mj S-Bb L-Bb L-Mj 
GO terms
Protein chains: GO type: GO description:
A/B/C/D=94-293 C cytoplasm
A/B/C/D=94-293 C chromatin assembly complex
A/B/C/D=94-293 C replication fork
A/B/C/D=94-293 C mitochondrion
A/B/C/D=94-293 C nuclear chromatin
A/B/C/D=94-293 C cytosol
A/B/C/D=94-293 C endoplasmic reticulum
A/B/C/D=94-293 C nucleus
A/B/C/D=94-293 C nuclear matrix
A/B/C/D=94-293 C nucleolus
A/B/C/D=94-293 C PML body
A/B/C/D=94-293 F ATP binding
A/B/C/D=94-293 F copper ion binding
A/B/C/D=94-293 F chromatin binding
A/B/C/D=94-293 F damaged DNA binding
A/B/C/D=94-293 F histone deacetylase regulator activity
A/B/C/D=94-293 F zinc ion binding
A/B/C/D=94-293 F RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
A/B/C/D=94-293 F DNA strand annealing activity
A/B/C/D=94-293 F RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
A/B/C/D=94-293 F transcription regulatory region DNA binding
A/B/C/D=94-293 P protein localization
A/B/C/D=94-293 P negative regulation of transcription from RNA polymerase II promoter
A/B/C/D=94-293 P T cell differentiation in thymus
A/B/C/D=94-293 P positive regulation of thymocyte apoptotic process
A/B/C/D=94-293 P positive regulation of histone deacetylation
A/B/C/D=94-293 P protein tetramerization
A/B/C/D=94-293 P chromosome organization
A/B/C/D=94-293 P replicative senescence
A/B/C/D=94-293 P cellular protein localization
A/B/C/D=94-293 P negative regulation of cell growth
A/B/C/D=94-293 P T cell proliferation involved in immune response
A/B/C/D=94-293 P DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
A/B/C/D=94-293 P response to X-ray
A/B/C/D=94-293 P cellular response to ionizing radiation
A/B/C/D=94-293 P cellular response to hypoxia
A/B/C/D=94-293 P cell proliferation
A/B/C/D=94-293 P cellular response to UV
A/B/C/D=94-293 P nucleotide-excision repair
A/B/C/D=94-293 P rRNA transcription
A/B/C/D=94-293 P response to antibiotic
A/B/C/D=94-293 P double-strand break repair
A/B/C/D=94-293 P positive regulation of protein oligomerization
A/B/C/D=94-293 P mitotic cell cycle arrest
A/B/C/D=94-293 P central nervous system development
A/B/C/D=94-293 P response to gamma radiation
A/B/C/D=94-293 P positive regulation of peptidyl-tyrosine phosphorylation
A/B/C/D=94-293 P multicellular organism growth
A/B/C/D=94-293 P positive regulation of reactive oxygen species metabolic process
A/B/C/D=94-293 P cell differentiation
A/B/C/D=94-293 P negative regulation of DNA replication
A/B/C/D=94-293 P B cell lineage commitment
A/B/C/D=94-293 P determination of adult lifespan
A/B/C/D=94-293 P positive regulation of transcription from RNA polymerase II promoter
A/B/C/D=94-293 P positive regulation of intrinsic apoptotic signaling pathway
A/B/C/D=94-293 P cellular response to glucose starvation
A/B/C/D=94-293 P transforming growth factor beta receptor signaling pathway
A/B/C/D=94-293 P Ras protein signal transduction
A/B/C/D=94-293 P negative regulation of neuroblast proliferation
A/B/C/D=94-293 P negative regulation of transforming growth factor beta receptor signaling pathway
A/B/C/D=94-293 P negative regulation of apoptotic process
A/B/C/D=94-293 P gastrulation
A/B/C/D=94-293 P negative regulation of helicase activity
A/B/C/D=94-293 P T cell lineage commitment
A/B/C/D=94-293 P DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
A/B/C/D=94-293 P neuron apoptotic process
A/B/C/D=94-293 P ER overload response
A/B/C/D=94-293 P positive regulation of cell aging
A/B/C/D=94-293 P positive regulation of neuron apoptotic process
A/B/C/D=94-293 P in utero embryonic development
A/B/C/D=94-293 P negative regulation of fibroblast proliferation
A/B/C/D=94-293 P base-excision repair
A/B/C/D=94-293 P oxidative stress-induced premature senescence
A/B/C/D=94-293 P positive regulation of release of cytochrome c from mitochondria
A/B/C/D=94-293 P regulation of mitochondrial membrane permeability
A/B/C/D=94-293 P cellular response to drug
A/B/C/D=94-293 P release of cytochrome c from mitochondria
A/B/C/D=94-293 P virus-host interaction
A/B/C/D=94-293 P response to salt stress
A/B/C/D=94-293 P protein import into nucleus, translocation
A/B/C/D=94-293 P blood coagulation
A/B/C/D=94-293 P DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
A/B/C/D=94-293 P apoptotic process
A/B/C/D=94-293 P cell cycle arrest
A/B/C/D=94-293 P somitogenesis
Sequences
Download file with secondary structure created by Stride  
2ac0.pdb1.pdb:   [ download sequences in FASTA format ]
E (dna): 
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F (dna): 
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G (dna): 
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H (dna): 
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A (protein): 
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B (protein): 
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C (protein): 
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D (protein): 
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