General information
PDB ID 2AS5
Title STRUCTURE OF THE DNA BINDING DOMAINS OF NFAT AND FOXP2 BOUND SPECIFICALLY TO DNA.
PDB header TRANSCRIPTION/DNA
Date 2005-08-22
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.7
Kind dna
Organism HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb2as5.pdb NMFG ABCD 0
Biounits:
2as5.pdb1.pdb NF AB 1
2as5.pdb2.pdb MG CD 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Forkhead Domain O15409_503-584 1.3e-29 1 CL0123 F 503 584 AB  H-Bb H-Mj S-Bb 
Forkhead Domain O15409_503-584 1.3e-29 1 CL0123 G 503 584 CD  H-Bb H-Mj S-Bb L-Bb 
RHD_dimer Domain Q13469_579-678 1.2e-26 1 CL0159 M 579 678   
RHD_DNA_bind Domain Q13469_410-570 5.5e-23 1 CL0073 M 410 570 CD  H-Bb S-Bb L-Bb L-Mj 
RHD_dimer Domain Q13469_579-678 1.2e-26 1 CL0159 N 579 678   
RHD_DNA_bind Domain Q13469_410-570 5.5e-23 1 CL0073 N 410 570 AB  H-Bb S-Bb S-Mj L-Bb L-Mj 
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: All beta proteins
  Fold: Immunoglobulin-like beta-sandwich
    Superfamily: E set domains
      Family: NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain
T-cell transcription factor NFAT1 (NFATC2) N 576 678 -
Class: All beta proteins
  Fold: Immunoglobulin-like beta-sandwich
    Superfamily: E set domains
      Family: NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain
T-cell transcription factor NFAT1 (NFATC2) M 576 678 -
Class: All beta proteins
  Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f
    Superfamily: p53-like transcription factors
      Family: Rel/Dorsal transcription factors, DNA-binding domain
T-cell transcription factor NFAT1 (NFATC), DNA-binding domain N 396 575 AB  H-Bb H-Mj S-Bb S-Mj L-Bb L-Mj 
Class: All beta proteins
  Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f
    Superfamily: p53-like transcription factors
      Family: Rel/Dorsal transcription factors, DNA-binding domain
T-cell transcription factor NFAT1 (NFATC), DNA-binding domain M 396 575 CD  H-Bb H-Mj S-Bb L-Bb L-Mj 
Class: All alpha proteins
  Fold: DNA/RNA-binding 3-helical bundle
    Superfamily: "Winged helix" DNA-binding domain
      Family: Forkhead DNA-binding domain
Forkhead box protein P2, FOXP2 F 503 584 AB -
Class: All alpha proteins
  Fold: DNA/RNA-binding 3-helical bundle
    Superfamily: "Winged helix" DNA-binding domain
      Family: Forkhead DNA-binding domain
Forkhead box protein P2, FOXP2 G 503 584 CD -
GO terms
Protein chains: GO type: GO description:
F/G=502-594 C nuclear chromatin
F/G=502-594 F androgen receptor binding
F/G=502-594 F DNA binding
F/G=502-594 F DNA-binding transcription factor activity
F/G=502-594 F DNA-binding transcription factor activity, RNA polymerase II-specific
F/G=502-594 F DNA-binding transcription repressor activity, RNA polymerase II-specific
F/G=502-594 F identical protein binding
F/G=502-594 F metal ion binding
F/G=502-594 F protein homodimerization activity
F/G=502-594 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
F/G=502-594 F sequence-specific DNA binding
F/G=502-594 P camera-type eye development
F/G=502-594 P caudate nucleus development
F/G=502-594 P cerebellum development
F/G=502-594 P cerebral cortex development
F/G=502-594 P innate vocalization behavior
F/G=502-594 P lung alveolus development
F/G=502-594 P negative regulation of transcription, DNA-templated
F/G=502-594 P positive regulation of epithelial cell proliferation involved in lung morphogenesis
F/G=502-594 P positive regulation of mesenchymal cell proliferation
F/G=502-594 P post-embryonic development
F/G=502-594 P putamen development
F/G=502-594 P response to testosterone
F/G=502-594 P righting reflex
F/G=502-594 P skeletal muscle tissue development
F/G=502-594 P smooth muscle tissue development
F/G=502-594 P vocal learning
M/N=392-678 C cytoplasm
M/N=392-678 C cytosol
M/N=392-678 C nuclear chromatin
M/N=392-678 C nucleoplasm
M/N=392-678 C nucleus
M/N=392-678 C ribonucleoprotein complex
M/N=392-678 C transcription regulator complex
M/N=392-678 F chromatin binding
M/N=392-678 F DNA binding
M/N=392-678 F DNA-binding transcription activator activity, RNA polymerase II-specific
M/N=392-678 F DNA-binding transcription factor activity
M/N=392-678 F DNA-binding transcription factor activity, RNA polymerase II-specific
M/N=392-678 F DNA-binding transcription repressor activity, RNA polymerase II-specific
M/N=392-678 F phosphatase binding
M/N=392-678 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
M/N=392-678 F sequence-specific double-stranded DNA binding
M/N=392-678 F transcription factor binding
M/N=392-678 P B cell receptor signaling pathway
M/N=392-678 P calcineurin-NFAT signaling cascade
M/N=392-678 P cell migration
M/N=392-678 P cellular response to DNA damage stimulus
M/N=392-678 P cytokine production
M/N=392-678 P Fc-epsilon receptor signaling pathway
M/N=392-678 P myotube cell development
M/N=392-678 P negative regulation of vascular associated smooth muscle cell differentiation
M/N=392-678 P positive regulation of B cell proliferation
M/N=392-678 P positive regulation of myoblast fusion
M/N=392-678 P positive regulation of transcription by RNA polymerase II
M/N=392-678 P positive regulation of transcription, DNA-templated
M/N=392-678 P regulation of regulatory T cell differentiation
M/N=392-678 P regulation of transcription, DNA-templated
M/N=392-678 P response to drug
Sequences
Download file with secondary structure created by Stride  
2as5.pdb1.pdb:   [ download sequences in FASTA format ]
A (dna): 
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B (dna): 
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F (protein): 
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N (protein): 
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2as5.pdb2.pdb:   [ download sequences in FASTA format ]
C (dna): 
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D (dna): 
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G (protein): 
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M (protein): 
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