General information
PDB ID 2AS5
Title STRUCTURE OF THE DNA BINDING DOMAINS OF NFAT AND FOXP2 BOUND SPECIFICALLY TO DNA.
PDB header TRANSCRIPTION/DNA
Date 2005-08-22
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.7
Kind dna
Organism HOMO SAPIENS
Download
complex
View in
Jmol
Quick Links
PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb2as5.pdb NMFG ABCD 0
Biounits:
2as5.pdb1.pdb NF AB 1
2as5.pdb2.pdb MG CD 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Forkhead Domain O15409_503-584 2.6e-29 1 CL0123 F 504 584 AB  H-Bb H-Mj S-Bb 
Forkhead Domain O15409_503-584 2.6e-29 1 CL0123 G 504 584 CD  H-Bb H-Mj S-Bb 
RHD_dimer Domain Q13469_579-678 6.5e-26 1 CL0159 M 579 678   
RHD_DNA_bind Domain Q13469_410-570 4.7e-23 1 CL0073 M 410 570 CD  H-Bb S-Bb L-Bb L-Mj 
RHD_dimer Domain Q13469_579-678 6.5e-26 1 CL0159 N 579 678   
RHD_DNA_bind Domain Q13469_410-570 4.7e-23 1 CL0073 N 410 570 AB  H-Bb S-Bb S-Mj L-Bb L-Mj 
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: All alpha proteins
  Fold: DNA/RNA-binding 3-helical bundle
    Superfamily: "Winged helix" DNA-binding domain
      Family: Forkhead DNA-binding domain
Forkhead box protein P2, FOXP2 F 503 584 AB -
Class: All alpha proteins
  Fold: DNA/RNA-binding 3-helical bundle
    Superfamily: "Winged helix" DNA-binding domain
      Family: Forkhead DNA-binding domain
Forkhead box protein P2, FOXP2 G 503 584 CD -
Class: All beta proteins
  Fold: Immunoglobulin-like beta-sandwich
    Superfamily: E set domains
      Family: NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain
T-cell transcription factor NFAT1 (NFATC2) M 576 678 -
Class: All beta proteins
  Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f
    Superfamily: p53-like transcription factors
      Family: Rel/Dorsal transcription factors, DNA-binding domain
T-cell transcription factor NFAT1 (NFATC), DNA-binding domain M 396 575 CD  H-Bb H-Mj S-Bb L-Bb L-Mj 
Class: All beta proteins
  Fold: Immunoglobulin-like beta-sandwich
    Superfamily: E set domains
      Family: NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain
T-cell transcription factor NFAT1 (NFATC2) N 576 678 -
Class: All beta proteins
  Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f
    Superfamily: p53-like transcription factors
      Family: Rel/Dorsal transcription factors, DNA-binding domain
T-cell transcription factor NFAT1 (NFATC), DNA-binding domain N 396 575 AB  H-Bb H-Mj S-Bb S-Mj L-Bb L-Mj 
GO terms
Protein chains: GO type: GO description:
F/G=503-594 C transcription factor complex
F/G=503-594 C cytoplasm
F/G=503-594 F double-stranded DNA binding
F/G=503-594 F chromatin binding
F/G=503-594 F zinc ion binding
F/G=503-594 F DNA binding, bending
F/G=503-594 F sequence-specific DNA binding
F/G=503-594 F RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
F/G=503-594 P caudate nucleus development
F/G=503-594 P negative regulation of transcription, DNA-dependent
F/G=503-594 P positive regulation of epithelial cell proliferation involved in lung morphogenesis
F/G=503-594 P post-embryonic development
F/G=503-594 P positive regulation of mesenchymal cell proliferation
F/G=503-594 P righting reflex
F/G=503-594 P skeletal muscle tissue development
F/G=503-594 P camera-type eye development
F/G=503-594 P putamen development
F/G=503-594 P cerebellum development
F/G=503-594 P regulation of sequence-specific DNA binding transcription factor activity
F/G=503-594 P embryo development
F/G=503-594 P vocal learning
F/G=503-594 P growth
F/G=503-594 P pattern specification process
F/G=503-594 P cerebral cortex development
F/G=503-594 P smooth muscle tissue development
F/G=503-594 P lung alveolus development
M/N=392-678 C actin cytoskeleton
M/N=392-678 C plasma membrane
M/N=392-678 C nucleus
M/N=392-678 C ribonucleoprotein complex
M/N=392-678 C cytosol
M/N=392-678 F transcription regulatory region DNA binding
M/N=392-678 F DNA binding
M/N=392-678 F sequence-specific DNA binding transcription factor activity
M/N=392-678 P positive regulation of B cell proliferation
M/N=392-678 P response to DNA damage stimulus
M/N=392-678 P response to drug
M/N=392-678 P transcription, DNA-dependent
M/N=392-678 P positive regulation of transcription, DNA-dependent
M/N=392-678 P cytokine production
M/N=392-678 P B cell receptor signaling pathway
M/N=392-678 P positive regulation of transcription from RNA polymerase II promoter
Sequences
Download file with secondary structure created by Stride  
2as5.pdb1.pdb:   [ download sequences in FASTA format ]
A (dna): 
Click "SHOW" for view sequence
B (dna): 
Click "SHOW" for view sequence
F (protein): 
Click "SHOW" for view sequence
N (protein): 
Click "SHOW" for view sequence
2as5.pdb2.pdb:   [ download sequences in FASTA format ]
C (dna): 
Click "SHOW" for view sequence
D (dna): 
Click "SHOW" for view sequence
G (protein): 
Click "SHOW" for view sequence
M (protein): 
Click "SHOW" for view sequence
© NPIDB team 2003 - 2019

text