General information
PDB ID 2FO1
Title CRYSTAL STRUCTURE OF THE CSL-NOTCH-MASTERMIND TERNARY COMPLEX BOUND TO DNA
PDB header GENE REGULATION/SIGNALLING PROTEIN/DNA
Date 2006-01-12
Experimental method X-RAY DIFFRACTION
Resolution (A) 3.12
Kind dna
Organism CAENORHABDITIS ELEGANS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb2fo1.pdb ADE BC 0
Biounits:
2fo1.pdb1.pdb ADE BC 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
BTD Domain Q8MXE7_382-534 7e-73 1 CL0066 A 384 536 B  S-Bb L-Mn 
LAG1-DNAbind Domain Q8MXE7_215-378 3.7e-44 1 CL0073 A 217 383 BC  L-Bb L-Mj 
TIG Domain 0.000086 1 CL0159 A 571 658
Activator_LAG-3 Family Q09260_52-114 1.6e-32 1 No_clan D 52 114   
Ank_2 Repeat 0.0000000008 1 CL0465 E 1131 1238
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: All beta proteins
  Fold: Immunoglobulin-like beta-sandwich
    Superfamily: E set domains
      Family: NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain
DNA-binding protein LAG-1 (CSL) A 542 660 -
Class: All beta proteins
  Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f
    Superfamily: p53-like transcription factors
      Family: DNA-binding protein LAG-1 (CSL)
DNA-binding protein LAG-1 (CSL) A 196 380 BC  L-Bb L-Mj 
Class: All beta proteins
  Fold: beta-Trefoil
    Superfamily: DNA-binding protein LAG-1 (CSL)
      Family: DNA-binding protein LAG-1 (CSL)
DNA-binding protein LAG-1 (CSL) A 381 541 B  S-Bb L-Mn 
Class: All alpha proteins
  Fold: Non-globular all-alpha subunits of globular proteins
    Superfamily: Lag-3 N-terminal region
      Family: Lag-3 N-terminal region
Abnormal cell lineage protein 3, Lag-3 D 52 114 -
Class: Alpha and beta proteins (a+b)
  Fold: beta-hairpin-alpha-hairpin repeat
    Superfamily: Ankyrin repeat
      Family: Ankyrin repeat
Lin-12 E 1021 1297 -
GO terms
Protein chains: GO type: GO description:
D=49-132 C nucleus
D=49-132 P regulation of cell proliferation
D=49-132 P germline cell cycle switching, mitotic to meiotic cell cycle
D=49-132 P embryo development ending in birth or egg hatching
D=49-132 P nematode larval development
D=49-132 P hermaphrodite genitalia development
D=49-132 P regulation of meiosis
D=49-132 P regulation of transcription, DNA-dependent
D=49-132 P transcription, DNA-dependent
D=49-132 P morphogenesis of an epithelium
D=49-132 P growth
E=931-1301 C apical plasma membrane
E=931-1301 C integral to membrane
E=931-1301 F transmembrane signaling receptor activity
E=931-1301 F calcium ion binding
E=931-1301 P locomotion
E=931-1301 P Notch signaling pathway
E=931-1301 P cell fate specification
E=931-1301 P cell-cell signaling involved in cell fate commitment
E=931-1301 P dauer exit
E=931-1301 P oviposition
E=931-1301 P vulval development
Sequences
Download file with secondary structure created by Stride  
2fo1.pdb1.pdb:   [ download sequences in FASTA format ]
B (dna): 
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C (dna): 
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A (protein): 
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D (protein): 
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E (protein): 
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