General information
PDB ID 2FO1
Title CRYSTAL STRUCTURE OF THE CSL-NOTCH-MASTERMIND TERNARY COMPLEX BOUND TO DNA
PDB header GENE REGULATION/SIGNALLING PROTEIN/DNA
Date 2006-01-12
Experimental method X-RAY DIFFRACTION
Resolution (A) 3.12
Kind dna
Organism CAENORHABDITIS ELEGANS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb2fo1.pdb ADE BC 0
Biounits:
2fo1.pdb1.pdb ADE BC 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
BTD Domain Q8MXE7_409-534 1.2e-53 1 CL0066 A 411 536   
LAG1-DNAbind Domain Q8MXE7_215-378 2e-41 1 CL0073 A 217 383 BC  L-Bb L-Mj 
TIG_SUH Domain Q8MXE7_560-656 2.7e-26 1 CL0159 A 562 658   
Activator_LAG-3 Family Q09260_52-114 1.8e-32 1 No_clan D 52 114   
Ank_2 Repeat P14585_1056-1157 1.4e-09 1 CL0465 E 1131 1238   
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: All beta proteins
  Fold: Immunoglobulin-like beta-sandwich
    Superfamily: E set domains
      Family: NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain
DNA-binding protein LAG-1 (CSL) A 542 660 -
Class: All beta proteins
  Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f
    Superfamily: p53-like transcription factors
      Family: DNA-binding protein LAG-1 (CSL)
DNA-binding protein LAG-1 (CSL) A 196 380 BC  L-Bb L-Mj 
Class: All beta proteins
  Fold: beta-Trefoil
    Superfamily: DNA-binding protein LAG-1 (CSL)
      Family: DNA-binding protein LAG-1 (CSL)
DNA-binding protein LAG-1 (CSL) A 381 541 B  S-Bb L-Mn 
Class: All alpha proteins
  Fold: Non-globular all-alpha subunits of globular proteins
    Superfamily: Lag-3 N-terminal region
      Family: Lag-3 N-terminal region
Abnormal cell lineage protein 3, Lag-3 D 52 114 -
Class: Alpha and beta proteins (a+b)
  Fold: beta-hairpin-alpha-hairpin repeat
    Superfamily: Ankyrin repeat
      Family: Ankyrin repeat
Lin-12 E 1021 1297 -
GO terms
Protein chains: GO type: GO description:
D=49-132 C nucleus
D=49-132 C RNA polymerase II transcription regulator complex
D=49-132 F transcription coactivator activity
D=49-132 P Notch signaling pathway
D=49-132 P positive regulation of stem cell proliferation
D=49-132 P positive regulation of transcription by RNA polymerase II
E=931-1301 C apical plasma membrane
E=931-1301 C integral component of membrane
E=931-1301 C nucleus
E=931-1301 C plasma membrane
E=931-1301 C RNA polymerase II transcription regulator complex
E=931-1301 F calcium ion binding
E=931-1301 F Notch binding
E=931-1301 F RNA polymerase II transcription factor binding
E=931-1301 F transmembrane signaling receptor activity
E=931-1301 P cell fate specification
E=931-1301 P cell-cell signaling involved in cell fate commitment
E=931-1301 P dauer exit
E=931-1301 P nematode larval development
E=931-1301 P Notch signaling pathway
E=931-1301 P oviposition
E=931-1301 P positive regulation of mesodermal cell fate specification
E=931-1301 P regulation of cell fate specification
E=931-1301 P regulation of mesodermal cell fate specification
E=931-1301 P regulation of vulval development
E=931-1301 P vulval development
Sequences
Download file with secondary structure created by Stride  
2fo1.pdb1.pdb:   [ download sequences in FASTA format ]
B (dna): 
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C (dna): 
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A (protein): 
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D (protein): 
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E (protein): 
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