General information
PDB ID 2GWS
Title CRYSTAL STRUCTURE OF HUMAN DNA POLYMERASE LAMBDA WITH A G/G MISMATCH IN THE PRIMER TERMINUS
PDB header TRANSFERASE/DNA
Date 2006-05-05
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.4
Kind dna
Organism HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
 PDIdb 
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb2gws.pdb AEIM TPDFGHJKLNRQ 0
Biounits:
2gws.pdb1.pdb A TPD 1
2gws.pdb2.pdb E FGH 1
2gws.pdb3.pdb I JKL 1
2gws.pdb4.pdb M NRQ 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
DNA_pol_B_palm Domain Q9UGP5_386-496 4.9e-35 1 CL0260 A 386 496 PT  S-Bb S-Mn 
DNA_pol_lambd_f Domain Q9UGP5_336-384 2.7e-21 1 CL0198 A 336 384 PT  H-Bb L-Bb 
HHH_8 Domain Q9UGP5_253-318 1e-18 1 CL0198 A 253 318 DT   
DNA_pol_B_palm Domain Q9UGP5_386-496 4.9e-35 1 CL0260 E 386 496 FG  S-Bb S-Mn 
DNA_pol_lambd_f Domain Q9UGP5_336-384 2.7e-21 1 CL0198 E 336 384 FG  H-Bb L-Bb 
HHH_8 Domain Q9UGP5_253-318 1e-18 1 CL0198 E 253 318 HF   
DNA_pol_B_palm Domain Q9UGP5_386-496 4.9e-35 1 CL0260 I 386 496 JK  S-Bb S-Mn 
DNA_pol_lambd_f Domain Q9UGP5_336-384 2.7e-21 1 CL0198 I 336 384 JK  H-Bb L-Bb 
HHH_8 Domain Q9UGP5_253-318 1e-18 1 CL0198 I 253 318 LJ   
DNA_pol_B_palm Domain Q9UGP5_386-496 4.9e-35 1 CL0260 M 386 496 NR  S-Bb S-Mn 
DNA_pol_lambd_f Domain Q9UGP5_336-384 2.7e-21 1 CL0198 M 336 384 NR  H-Bb L-Bb 
HHH_8 Domain Q9UGP5_253-318 1e-18 1 CL0198 M 253 318 QN   
DNA_pol_B_thumb Family Q9UGP5_502-574 3e-22 1 No_clan A 502 574 T   
DNA_pol_B_thumb Family Q9UGP5_502-574 3e-22 1 No_clan E 502 574 F   
DNA_pol_B_thumb Family Q9UGP5_502-574 3e-22 1 No_clan I 502 574 J   
DNA_pol_B_thumb Family Q9UGP5_502-574 3e-22 1 No_clan M 502 574 NR  H-Mn L-Mn 
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: All alpha proteins
  Fold: SAM domain-like
    Superfamily: DNA polymerase beta, N-terminal domain-like
      Family: DNA polymerase beta, N-terminal domain-like
DNA polymerase lambda A 249 327 DT  H-Bb L-Bb 
Class: All alpha proteins
  Fold: SAM domain-like
    Superfamily: DNA polymerase beta, N-terminal domain-like
      Family: DNA polymerase beta, N-terminal domain-like
DNA polymerase lambda E 250 327 HF  H-Bb L-Bb 
Class: All alpha proteins
  Fold: SAM domain-like
    Superfamily: DNA polymerase beta, N-terminal domain-like
      Family: DNA polymerase beta, N-terminal domain-like
DNA polymerase lambda I 250 327 LJ  H-Bb L-Bb 
Class: All alpha proteins
  Fold: SAM domain-like
    Superfamily: DNA polymerase beta, N-terminal domain-like
      Family: DNA polymerase beta, N-terminal domain-like
DNA polymerase lambda M 250 327 QN  H-Bb L-Bb 
Class: All alpha proteins
  Fold: SAM domain-like
    Superfamily: PsbU/PolX domain-like
      Family: DNA polymerase beta-like, second domain
DNA polymerase lambda A 329 385 PT -
Class: Alpha and beta proteins (a+b)
  Fold: Nucleotidyltransferase
    Superfamily: Nucleotidyltransferase
      Family: DNA polymerase beta-like
DNA polymerase lambda A 386 575 PT -
Class: All alpha proteins
  Fold: SAM domain-like
    Superfamily: PsbU/PolX domain-like
      Family: DNA polymerase beta-like, second domain
DNA polymerase lambda E 329 385 FG -
Class: Alpha and beta proteins (a+b)
  Fold: Nucleotidyltransferase
    Superfamily: Nucleotidyltransferase
      Family: DNA polymerase beta-like
DNA polymerase lambda E 386 575 FG -
Class: All alpha proteins
  Fold: SAM domain-like
    Superfamily: PsbU/PolX domain-like
      Family: DNA polymerase beta-like, second domain
DNA polymerase lambda I 329 385 JK -
Class: Alpha and beta proteins (a+b)
  Fold: Nucleotidyltransferase
    Superfamily: Nucleotidyltransferase
      Family: DNA polymerase beta-like
DNA polymerase lambda I 386 575 JK -
Class: All alpha proteins
  Fold: SAM domain-like
    Superfamily: PsbU/PolX domain-like
      Family: DNA polymerase beta-like, second domain
DNA polymerase lambda M 329 385 NR -
Class: Alpha and beta proteins (a+b)
  Fold: Nucleotidyltransferase
    Superfamily: Nucleotidyltransferase
      Family: DNA polymerase beta-like
DNA polymerase lambda M 386 575 NR -
GO terms
Protein chains: GO type: GO description:
A/E/I/M=242-575 C nucleoplasm
A/E/I/M=242-575 C nucleus
A/E/I/M=242-575 F 5'-deoxyribose-5-phosphate lyase activity
A/E/I/M=242-575 F DNA binding
A/E/I/M=242-575 F DNA-directed DNA polymerase activity
A/E/I/M=242-575 F metal ion binding
A/E/I/M=242-575 P base-excision repair, gap-filling
A/E/I/M=242-575 P DNA biosynthetic process
A/E/I/M=242-575 P DNA replication
A/E/I/M=242-575 P double-strand break repair via homologous recombination
A/E/I/M=242-575 P double-strand break repair via nonhomologous end joining
A/E/I/M=242-575 P nucleotide-excision repair
A/E/I/M=242-575 P somatic hypermutation of immunoglobulin genes
Sequences
Download file with secondary structure created by Stride  
2gws.pdb1.pdb:   [ download sequences in FASTA format ]
D (dna): 
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P (dna): 
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T (dna): 
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A (protein): 
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2gws.pdb2.pdb:   [ download sequences in FASTA format ]
F (dna): 
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G (dna): 
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H (dna): 
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E (protein): 
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2gws.pdb3.pdb:   [ download sequences in FASTA format ]
J (dna): 
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K (dna): 
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L (dna): 
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I (protein): 
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2gws.pdb4.pdb:   [ download sequences in FASTA format ]
N (dna): 
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Q (dna): 
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R (dna): 
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M (protein): 
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