General information
PDB ID 2I9T
Title STRUCTURE OF NF-KB P65-P50 HETERODIMER BOUND TO PRDII ELEMENT OF B- INTERFERON PROMOTER
PDB header TRANSCRIPTION/DNA
Date 2006-09-06
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.8
Kind dna
Organism MUS MUSCULUS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb2i9t.pdb AB CD 0
Biounits:
2i9t.pdb1.pdb AB CD 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
RHD_DNA_bind Domain Q04207_21-186 7e-70 1 CL0073 A 21 186 CD  H-Bb H-Mj S-Mj L-Bb L-Mj 
RHD_dimer Domain Q04207_195-291 2.2e-37 1 CL0159 A 195 291   
RHD_DNA_bind Domain P25799_42-240 7.2e-74 1 CL0073 B 342 540 CD  H-Bb H-Mj S-Mj L-Bb L-Mj 
RHD_dimer Domain P25799_249-350 5.5e-42 1 CL0159 B 549 650 D  L-Bb 
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: All beta proteins
  Fold: Immunoglobulin-like beta-sandwich
    Superfamily: E set domains
      Family: NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain
p65 subunit of NF-kappa B (NFKB), dimerization domain A 191 291 -
Class: All beta proteins
  Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f
    Superfamily: p53-like transcription factors
      Family: Rel/Dorsal transcription factors, DNA-binding domain
p65 subunit of NF-kappa B (NFKB), N-terminal domain A 20 190 CD  H-Bb H-Mj L-Bb L-Mj 
Class: All beta proteins
  Fold: Immunoglobulin-like beta-sandwich
    Superfamily: E set domains
      Family: NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain
p50 subunit of NF-kappa B transcription factor B 548 650 D  L-Bb 
Class: All beta proteins
  Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f
    Superfamily: p53-like transcription factors
      Family: Rel/Dorsal transcription factors, DNA-binding domain
p50 subunit of NF-kappa B (NFKB), N-terminal domain B 339 547 CD  H-Bb H-Mj L-Bb L-Mj 
GO terms
Protein chains: GO type: GO description:
A=19-291 C NF-kappaB complex
A=19-291 F DNA binding
A=19-291 F RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
A=19-291 F chromatin binding
A=19-291 P cellular response to lipopolysaccharide
A=19-291 P organ morphogenesis
A=19-291 P response to drug
A=19-291 P hair follicle development
A=19-291 P response to cAMP
A=19-291 P acetaldehyde metabolic process
A=19-291 P defense response
A=19-291 P response to mechanical stimulus
A=19-291 P negative regulation of insulin receptor signaling pathway
A=19-291 P response to progesterone stimulus
A=19-291 P aging
A=19-291 P positive regulation of transcription, DNA-dependent
A=19-291 P response to insulin stimulus
A=19-291 P response to cytokine stimulus
A=19-291 P positive regulation of chondrocyte differentiation
A=19-291 P positive regulation of I-kappaB kinase/NF-kappaB cascade
A=19-291 P positive regulation of NF-kappaB transcription factor activity
A=19-291 P positive regulation of cell proliferation
A=19-291 P positive regulation of Schwann cell differentiation
A=19-291 P liver development
A=19-291 P response to cobalamin
A=19-291 P response to morphine
A=19-291 P response to hydrogen peroxide
A=19-291 P response to muramyl dipeptide
A=19-291 P negative regulation of protein catabolic process
A=19-291 P positive regulation of interleukin-12 biosynthetic process
A=19-291 P regulation of inflammatory response
A=19-291 P response to amino acid stimulus
B=39-350 C cytosol
B=39-350 C nucleus
B=39-350 C protein complex
B=39-350 C mitochondrion
B=39-350 F transcription regulatory region sequence-specific DNA binding
B=39-350 F regulatory region DNA binding
B=39-350 F nucleic acid binding transcription factor activity
B=39-350 F sequence-specific DNA binding transcription factor activity
B=39-350 F double-stranded DNA binding
B=39-350 F sequence-specific DNA binding
B=39-350 P positive regulation of hyaluronan biosynthetic process
B=39-350 P transcription, DNA-dependent
B=39-350 P cellular response to interleukin-1
B=39-350 P positive regulation of transcription from RNA polymerase II promoter
B=39-350 P lymph node development
B=39-350 P apoptotic process
B=39-350 P negative regulation of cytokine production
B=39-350 P anti-apoptosis
B=39-350 P positive regulation of canonical Wnt receptor signaling pathway
B=39-350 P signal transduction
B=39-350 P negative regulation of calcidiol 1-monooxygenase activity
B=39-350 P cellular response to mechanical stimulus
B=39-350 P response to oxidative stress
B=39-350 P negative regulation of transcription from RNA polymerase II promoter
B=39-350 P response to copper ion
B=39-350 P response to bacterium
B=39-350 P negative regulation of interleukin-12 biosynthetic process
Sequences
Download file with secondary structure created by Stride  
2i9t.pdb1.pdb:   [ download sequences in FASTA format ]
C (dna): 
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D (dna): 
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A (protein): 
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B (protein): 
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