General information
PDB ID 2J0S
Title THE CRYSTAL STRUCTURE OF THE EXON JUNCTION COMPLEX AT 2.2 A RESOLUTION
PDB header HYDROLASE
Date 2006-08-04
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.21
Kind rna
Organism HOMO SAPIENS
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Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb2j0s.pdb ACDT E 0
Biounits:
2j0s.pdb1.pdb ACDT E 1
Pfam domains
Name: Type: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Action:
DEAD Domain 2.2e-42 1 CL0023 A 62 228 E
RRM_1 Domain 4.9e-19 1 CL0221 D 75 145
Btz Domain 0.00000000025 1 No_clan T 169 217 E
Helicase_C Family 2.3e-31 1 CL0023 A 263 372 E
Mago_nashi Family 2.5e-80 1 No_clan C 5 146
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: Alpha and beta proteins (a/b)
  Fold: P-loop containing nucleoside triphosphate hydrolases
    Superfamily: P-loop containing nucleoside triphosphate hydrolases
      Family: Tandem AAA-ATPase domain
Probable ATP-dependent RNA helicase DDX48 A 22 243 E -
Class: Alpha and beta proteins (a/b)
  Fold: P-loop containing nucleoside triphosphate hydrolases
    Superfamily: P-loop containing nucleoside triphosphate hydrolases
      Family: Tandem AAA-ATPase domain
Probable ATP-dependent RNA helicase DDX48 A 244 411 E -
Class: Alpha and beta proteins (a+b)
  Fold: Mago nashi protein
    Superfamily: Mago nashi protein
      Family: Mago nashi protein
Mago nashi protein C 4 145 -
Class: Alpha and beta proteins (a+b)
  Fold: Ferredoxin-like
    Superfamily: RNA-binding domain, RBD
      Family: Canonical RBD
RNA-binding protein 8 D 66 154 -
GO terms
Protein chains: GO type: GO description:
A=2-411 F ATP binding
A=2-411 F poly(A) RNA binding
A=2-411 F ATP-dependent RNA helicase activity
A=2-411 P positive regulation of nuclear mRNA splicing, via spliceosome
A=2-411 P rRNA processing
A=2-411 P negative regulation of translation
A=2-411 P nuclear-transcribed mRNA poly(A) tail shortening
A=2-411 P positive regulation of transcription from RNA polymerase II promoter
A=2-411 P positive regulation of translation
A=2-411 P mRNA transport
A=2-411 P cytokine-mediated signaling pathway
C=1-146 C nucleoplasm
C=1-146 C cytosol
C=1-146 C catalytic step 2 spliceosome
C=1-146 C nuclear speck
C=1-146 C exon-exon junction complex
C=1-146 F RNA binding
C=1-146 P nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
C=1-146 P regulation of translation
C=1-146 P mRNA export from nucleus
C=1-146 P termination of RNA polymerase II transcription
C=1-146 P mRNA 3'-end processing
C=1-146 P nuclear mRNA splicing, via spliceosome
D=66-154 F nucleotide binding
D=66-154 F mRNA binding
T=137-286 C ribonucleoprotein complex
T=137-286 C perinuclear region of cytoplasm
T=137-286 P intracellular mRNA localization
T=137-286 P RNA splicing
T=137-286 P response to stress
T=137-286 P gene expression
T=137-286 P mRNA processing
Sequences
Download file with secondary structure created by Stride  
2j0s.pdb1.pdb:   [ download sequences in FASTA format ]
A (protein): 
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C (protein): 
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D (protein): 
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T (protein): 
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E (rna): 
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