General information
PDB ID 2LEF
Title LEF1 HMG DOMAIN (FROM MOUSE), COMPLEXED WITH DNA (15BP), NMR, 12 STRUCTURES
PDB header GENE REGULATION/DNA
Date 1998-10-13
Experimental method SOLUTION NMR
Resolution (A) N/A
Kind dna
Organism MUS MUSCULUS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
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Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb2lef.pdb A BC 12
NMR models:
2lef.MDL1.pdb A BC 1
2lef.MDL2.pdb A BC 1
2lef.MDL3.pdb A BC 1
2lef.MDL4.pdb A BC 1
2lef.MDL5.pdb A BC 1
2lef.MDL6.pdb A BC 1
2lef.MDL7.pdb A BC 1
2lef.MDL8.pdb A BC 1
2lef.MDL9.pdb A BC 1
2lef.MDL10.pdb A BC 1
2lef.MDL11.pdb A BC 1
2lef.MDL12.pdb A BC 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
HMG_box Domain P27782_297-365 1.4e-22 1 CL0114 A 3 71 BC  H-Bb H-Mj H-Mn L-Bb 
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: All alpha proteins
  Fold: HMG-box
    Superfamily: HMG-box
      Family: HMG-box
Lymphoid enhancer-binding factor, LEF1 A N/A N/A BC -
GO terms
Protein chains: GO type: GO description:
A=296-380 C beta-catenin-TCF complex
A=296-380 C cytoplasm
A=296-380 C nucleus
A=296-380 C protein-DNA complex
A=296-380 C transcription regulator complex
A=296-380 F armadillo repeat domain binding
A=296-380 F beta-catenin binding
A=296-380 F C2H2 zinc finger domain binding
A=296-380 F chromatin binding
A=296-380 F cis-regulatory region sequence-specific DNA binding
A=296-380 F cysteine-type endopeptidase inhibitor activity involved in apoptotic process
A=296-380 F DNA binding
A=296-380 F DNA binding, bending
A=296-380 F DNA-binding transcription activator activity, RNA polymerase II-specific
A=296-380 F DNA-binding transcription factor activity
A=296-380 F DNA-binding transcription factor activity, RNA polymerase II-specific
A=296-380 F estrogen receptor activity
A=296-380 F estrogen receptor binding
A=296-380 F gamma-catenin binding
A=296-380 F histone binding
A=296-380 F histone deacetylase binding
A=296-380 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
A=296-380 F RNA polymerase II transcription regulatory region sequence-specific DNA binding
A=296-380 F sequence-specific DNA binding
A=296-380 F sequence-specific double-stranded DNA binding
A=296-380 F transcription factor binding
A=296-380 F transcription regulatory region sequence-specific DNA binding
A=296-380 P alpha-beta T cell differentiation
A=296-380 P anatomical structure regression
A=296-380 P apoptotic process involved in blood vessel morphogenesis
A=296-380 P apoptotic process involved in morphogenesis
A=296-380 P B cell proliferation
A=296-380 P BMP signaling pathway
A=296-380 P branching involved in blood vessel morphogenesis
A=296-380 P canonical Wnt signaling pathway
A=296-380 P cell chemotaxis
A=296-380 P cell development
A=296-380 P cellular response to cytokine stimulus
A=296-380 P cellular response to interleukin-4
A=296-380 P chorio-allantoic fusion
A=296-380 P dentate gyrus development
A=296-380 P embryonic limb morphogenesis
A=296-380 P epithelial to mesenchymal transition
A=296-380 P face morphogenesis
A=296-380 P forebrain neuroblast division
A=296-380 P forebrain radial glial cell differentiation
A=296-380 P formation of radial glial scaffolds
A=296-380 P hippocampus development
A=296-380 P histone H3 acetylation
A=296-380 P histone H4 acetylation
A=296-380 P mammary gland development
A=296-380 P negative regulation of apoptotic process
A=296-380 P negative regulation of apoptotic process in bone marrow cell
A=296-380 P negative regulation of cell-cell adhesion
A=296-380 P negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
A=296-380 P negative regulation of DNA binding
A=296-380 P negative regulation of estrogen receptor binding
A=296-380 P negative regulation of interleukin-13 production
A=296-380 P negative regulation of interleukin-4 production
A=296-380 P negative regulation of interleukin-5 production
A=296-380 P negative regulation of striated muscle tissue development
A=296-380 P negative regulation of transcription by RNA polymerase II
A=296-380 P negative regulation of transcription, DNA-templated
A=296-380 P neutrophil differentiation
A=296-380 P odontoblast differentiation
A=296-380 P odontogenesis of dentin-containing tooth
A=296-380 P osteoblast differentiation
A=296-380 P paraxial mesoderm formation
A=296-380 P positive regulation by host of viral transcription
A=296-380 P positive regulation of cell cycle process
A=296-380 P positive regulation of cell growth
A=296-380 P positive regulation of cell migration
A=296-380 P positive regulation of cell population proliferation
A=296-380 P positive regulation of cell proliferation in bone marrow
A=296-380 P positive regulation of cell-cell adhesion
A=296-380 P positive regulation of epithelial to mesenchymal transition
A=296-380 P positive regulation of gamma-delta T cell differentiation
A=296-380 P positive regulation of gene expression
A=296-380 P positive regulation of granulocyte differentiation
A=296-380 P positive regulation of transcription by RNA polymerase II
A=296-380 P positive regulation of transcription, DNA-templated
A=296-380 P regulation of cell-cell adhesion
A=296-380 P regulation of transcription by RNA polymerase II
A=296-380 P regulation of transcription, DNA-templated
A=296-380 P regulation of Wnt signaling pathway
A=296-380 P secondary palate development
A=296-380 P sensory perception of taste
A=296-380 P somitogenesis
A=296-380 P sprouting angiogenesis
A=296-380 P T cell receptor V(D)J recombination
A=296-380 P T-helper 1 cell differentiation
A=296-380 P tongue development
A=296-380 P trachea gland development
A=296-380 P vasculature development
A=296-380 P Wnt signaling pathway
Sequences
Download file with secondary structure created by Stride  
2lef.MDL1.pdb:   [ download sequences in FASTA format ]
B (dna): 
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C (dna): 
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A (protein): 
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