General information
PDB ID 2O6G
Title CRYSTAL STRUCTURE OF IRF-3 BOUND TO THE INTERFERON-B ENHANCER
PDB header TRANSCRIPTION/DNA
Date 2006-12-07
Experimental method X-RAY DIFFRACTION
Resolution (A) 3.1
Kind dna
Organism HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb2o6g.pdb EFGH DC 0
Biounits:
2o6g.pdb1.pdb EFGH DC 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
IRF Domain Q14653_7-110 4e-36 1 CL0123 E 7 110 CD  H-Bb H-Mj S-Bb L-Bb L-Mn 
IRF Domain Q14653_7-110 3.7e-36 1 CL0123 F 7 110 CD  H-Bb H-Mj S-Bb L-Bb L-Mn 
IRF Domain Q14653_7-110 4e-36 1 CL0123 G 7 110 CD  H-Bb H-Mj L-Bb L-Mn 
IRF Domain Q14653_7-110 3.7e-36 1 CL0123 H 7 110 CD  H-Bb H-Mj S-Bb L-Bb L-Mn 
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: All alpha proteins
  Fold: DNA/RNA-binding 3-helical bundle
    Superfamily: "Winged helix" DNA-binding domain
      Family: Interferon regulatory factor
Interferon regulatory factor 3, IRF-3 E 3 112 CD  H-Bb H-Mj S-Bb L-Bb 
Class: All alpha proteins
  Fold: DNA/RNA-binding 3-helical bundle
    Superfamily: "Winged helix" DNA-binding domain
      Family: Interferon regulatory factor
Interferon regulatory factor 3, IRF-3 F 4 111 CD  H-Bb H-Mj S-Bb L-Bb L-Mn 
Class: All alpha proteins
  Fold: DNA/RNA-binding 3-helical bundle
    Superfamily: "Winged helix" DNA-binding domain
      Family: Interferon regulatory factor
Interferon regulatory factor 3, IRF-3 G 3 112 CD  H-Bb H-Mj L-Bb 
Class: All alpha proteins
  Fold: DNA/RNA-binding 3-helical bundle
    Superfamily: "Winged helix" DNA-binding domain
      Family: Interferon regulatory factor
Interferon regulatory factor 3, IRF-3 H 4 111 CD  H-Bb H-Mj S-Bb L-Bb 
GO terms
Protein chains: GO type: GO description:
E/F/G/H=1-123 C plasma membrane
E/F/G/H=1-123 C cytosol
E/F/G/H=1-123 C endosome membrane
E/F/G/H=1-123 C nucleoplasm
E/F/G/H=1-123 F transcription cofactor activity
E/F/G/H=1-123 F transcription regulatory region DNA binding
E/F/G/H=1-123 F DNA binding
E/F/G/H=1-123 F sequence-specific DNA binding transcription factor activity
E/F/G/H=1-123 P negative regulation of defense response to virus by host
E/F/G/H=1-123 P macrophage apoptotic process
E/F/G/H=1-123 P negative regulation of transcription from RNA polymerase II promoter
E/F/G/H=1-123 P induction of apoptosis
E/F/G/H=1-123 P toll-like receptor 4 signaling pathway
E/F/G/H=1-123 P cellular response to dsRNA
E/F/G/H=1-123 P type I interferon-mediated signaling pathway
E/F/G/H=1-123 P Toll signaling pathway
E/F/G/H=1-123 P virus-host interaction
E/F/G/H=1-123 P negative regulation of interferon-beta biosynthetic process
E/F/G/H=1-123 P TRIF-dependent toll-like receptor signaling pathway
E/F/G/H=1-123 P lipopolysaccharide-mediated signaling pathway
E/F/G/H=1-123 P toll-like receptor 3 signaling pathway
E/F/G/H=1-123 P response to DNA damage stimulus
E/F/G/H=1-123 P negative regulation of type I interferon production
E/F/G/H=1-123 P MDA-5 signaling pathway
E/F/G/H=1-123 P positive regulation of cytokine secretion
E/F/G/H=1-123 P response to exogenous dsRNA
E/F/G/H=1-123 P interferon-gamma-mediated signaling pathway
E/F/G/H=1-123 P type I interferon biosynthetic process
E/F/G/H=1-123 P positive regulation of I-kappaB kinase/NF-kappaB cascade
E/F/G/H=1-123 P positive regulation of interferon-alpha production
E/F/G/H=1-123 P positive regulation of interferon-beta production
E/F/G/H=1-123 P transcription from RNA polymerase II promoter
Sequences
Download file with secondary structure created by Stride  
2o6g.pdb1.pdb:   [ download sequences in FASTA format ]
C (dna): 
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D (dna): 
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E (protein): 
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F (protein): 
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G (protein): 
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H (protein): 
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