General information
PDB ID 2O8C
Title HUMAN MUTSALPHA (MSH2/MSH6) BOUND TO ADP AND AN O6-METHYL-GUANINE T MISPAIR
PDB header DNA BINDING PROTEIN/DNA
Date 2006-12-12
Experimental method X-RAY DIFFRACTION
Resolution (A) 3.37
Kind dna
Organism HOMO SAPIENS
Download
complex
View in
Jmol
Quick Links
PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb2o8c.pdb AB EF 0
Biounits:
2o8c.pdb1.pdb AB EF 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
MutS_V Domain P43246_665-852 2.7e-78 1 CL0023 A 665 852   
MutS_III Domain P43246_305-609 5.1e-37 1 No_clan A 305 609 EF  S-Bb L-Bb 
MutS_II Domain P43246_145-290 4.4e-21 1 No_clan A 145 290   
MutS_IV Domain P43246_473-569 2.2e-20 1 No_clan A 473 569 EF  S-Bb L-Bb 
MutS_I Domain P43246_17-132 3.5e-20 1 No_clan A 17 132   
MutS_V Domain P52701_1130-1324 1.4e-59 1 CL0023 B 1130 1324   
MutS_III Domain P52701_738-1064 4.6e-40 1 No_clan B 738 1064 EF  L-Bb 
MutS_I Domain P52701_407-526 4e-34 1 No_clan B 407 526 EF  H-Bb S-Bb S-Mj S-Mn L-Bb L-Mj L-Mn 
MutS_IV Domain P52701_932-1024 3.8e-17 1 No_clan B 933 1024 EF  L-Bb 
MutS_II Domain P52701_537-703 2.3e-11 1 No_clan B 537 703   
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
A=1-934 C membrane
A=1-934 C mismatch repair complex
A=1-934 C MutSalpha complex
A=1-934 C MutSbeta complex
A=1-934 C nuclear chromosome, telomeric region
A=1-934 C nucleoplasm
A=1-934 C nucleus
A=1-934 F ATP binding
A=1-934 F centromeric DNA binding
A=1-934 F chromatin binding
A=1-934 F damaged DNA binding
A=1-934 F DNA binding
A=1-934 F DNA-dependent ATPase activity
A=1-934 F double-strand/single-strand DNA junction binding
A=1-934 F enzyme binding
A=1-934 F guanine/thymine mispair binding
A=1-934 F protein C-terminus binding
A=1-934 F protein homodimerization activity
A=1-934 F protein kinase binding
A=1-934 P B cell differentiation
A=1-934 P B cell mediated immunity
A=1-934 P cell cycle arrest
A=1-934 P determination of adult lifespan
A=1-934 P DNA recombination
A=1-934 P DNA repair
A=1-934 P double-strand break repair
A=1-934 P germ cell development
A=1-934 P in utero embryonic development
A=1-934 P intra-S DNA damage checkpoint
A=1-934 P intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
A=1-934 P isotype switching
A=1-934 P maintenance of DNA repeat elements
A=1-934 P male gonad development
A=1-934 P mismatch repair
A=1-934 P negative regulation of DNA recombination
A=1-934 P negative regulation of neuron apoptotic process
A=1-934 P oxidative phosphorylation
A=1-934 P positive regulation of helicase activity
A=1-934 P positive regulation of isotype switching to IgA isotypes
A=1-934 P positive regulation of isotype switching to IgG isotypes
A=1-934 P postreplication repair
A=1-934 P protein localization to chromatin
A=1-934 P response to UV-B
A=1-934 P response to X-ray
A=1-934 P somatic hypermutation of immunoglobulin genes
A=1-934 P somatic recombination of immunoglobulin gene segments
A=1-934 P somatic recombination of immunoglobulin genes involved in immune response
B=341-1360 C cytosol
B=341-1360 C Golgi apparatus
B=341-1360 C intracellular membrane-bounded organelle
B=341-1360 C mismatch repair complex
B=341-1360 C MutSalpha complex
B=341-1360 C nuclear chromatin
B=341-1360 C nucleoplasm
B=341-1360 C nucleus
B=341-1360 F ATP binding
B=341-1360 F chromatin binding
B=341-1360 F damaged DNA binding
B=341-1360 F DNA-dependent ATPase activity
B=341-1360 F enzyme binding
B=341-1360 F guanine/thymine mispair binding
B=341-1360 F methylated histone binding
B=341-1360 F mismatched DNA binding
B=341-1360 P determination of adult lifespan
B=341-1360 P DNA repair
B=341-1360 P interstrand cross-link repair
B=341-1360 P intrinsic apoptotic signaling pathway
B=341-1360 P intrinsic apoptotic signaling pathway in response to DNA damage
B=341-1360 P isotype switching
B=341-1360 P meiotic mismatch repair
B=341-1360 P mismatch repair
B=341-1360 P negative regulation of DNA recombination
B=341-1360 P positive regulation of helicase activity
B=341-1360 P pyrimidine dimer repair
B=341-1360 P response to UV
B=341-1360 P somatic hypermutation of immunoglobulin genes
B=341-1360 P somatic recombination of immunoglobulin gene segments
B=341-1360 P viral process
Sequences
Download file with secondary structure created by Stride  
2o8c.pdb1.pdb:   [ download sequences in FASTA format ]
E (dna): 
Click "SHOW" for view sequence
F (dna): 
Click "SHOW" for view sequence
A (protein): 
Click "SHOW" for view sequence
B (protein): 
Click "SHOW" for view sequence
© NPIDB team 2003 - 2021

text