General information
PDB ID 2RAM
Title A NOVEL DNA RECOGNITION MODE BY NF-KB P65 HOMODIMER
PDB header TRANSCRIPTION/DNA
Date 1997-11-23
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.4
Kind dna
Organism MUS MUSCULUS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
 PDIdb 
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb2ram.pdb AB CD 0
Biounits:
2ram.pdb1.pdb AB CD 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
RHD_DNA_bind Domain Q04207_21-186 6.9e-70 1 CL0073 A 21 186 CD   
RHD_dimer Domain Q04207_195-291 2.1e-37 1 CL0159 A 195 291 C   
RHD_DNA_bind Domain Q04207_21-186 6.9e-70 1 CL0073 B 21 186 D   
RHD_dimer Domain Q04207_195-291 2.1e-37 1 CL0159 B 195 291 D   
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: All beta proteins
  Fold: Immunoglobulin-like beta-sandwich
    Superfamily: E set domains
      Family: NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain
p65 subunit of NF-kappa B (NFKB), dimerization domain A 192 291 C  L-Bb 
Class: All beta proteins
  Fold: Immunoglobulin-like beta-sandwich
    Superfamily: E set domains
      Family: NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain
p65 subunit of NF-kappa B (NFKB), dimerization domain B 192 291 D  L-Bb 
Class: All beta proteins
  Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f
    Superfamily: p53-like transcription factors
      Family: Rel/Dorsal transcription factors, DNA-binding domain
p65 subunit of NF-kappa B (NFKB), N-terminal domain A 19 191 CD  S-Mj L-Bb L-Mj 
Class: All beta proteins
  Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f
    Superfamily: p53-like transcription factors
      Family: Rel/Dorsal transcription factors, DNA-binding domain
p65 subunit of NF-kappa B (NFKB), N-terminal domain B 19 191 DC  S-Bb S-Mj L-Bb 
GO terms
Protein chains: GO type: GO description:
A/B=19-291 C cytosol
A/B=19-291 C nucleus
A/B=19-291 C NF-kappaB complex
A/B=19-291 F sequence-specific DNA binding
A/B=19-291 F RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
A/B=19-291 F DNA binding
A/B=19-291 F chromatin binding
A/B=19-291 P regulation of inflammatory response
A/B=19-291 P positive regulation of NF-kappaB transcription factor activity
A/B=19-291 P positive regulation of Schwann cell differentiation
A/B=19-291 P response to cobalamin
A/B=19-291 P defense response
A/B=19-291 P positive regulation of interleukin-12 biosynthetic process
A/B=19-291 P response to mechanical stimulus
A/B=19-291 P negative regulation of protein catabolic process
A/B=19-291 P response to cAMP
A/B=19-291 P hair follicle development
A/B=19-291 P response to morphine
A/B=19-291 P response to cytokine stimulus
A/B=19-291 P response to hydrogen peroxide
A/B=19-291 P response to progesterone stimulus
A/B=19-291 P response to drug
A/B=19-291 P response to amino acid stimulus
A/B=19-291 P anti-apoptosis
A/B=19-291 P aging
A/B=19-291 P positive regulation of cell proliferation
A/B=19-291 P organ morphogenesis
A/B=19-291 P positive regulation of chondrocyte differentiation
A/B=19-291 P positive regulation of transcription, DNA-dependent
A/B=19-291 P response to muramyl dipeptide
A/B=19-291 P response to insulin stimulus
A/B=19-291 P cellular response to lipopolysaccharide
A/B=19-291 P negative regulation of insulin receptor signaling pathway
A/B=19-291 P acetaldehyde metabolic process
A/B=19-291 P positive regulation of I-kappaB kinase/NF-kappaB cascade
A/B=19-291 P liver development
Sequences
Download file with secondary structure created by Stride  
2ram.pdb1.pdb:   [ download sequences in FASTA format ]
C (dna): 
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D (dna): 
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A (protein): 
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B (protein): 
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