General information
PDB ID 2UZK
Title CRYSTAL STRUCTURE OF THE HUMAN FOXO3A-DBD BOUND TO DNA
PDB header TRANSCRIPTION
Date 2007-04-30
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.7
Kind dna
Organism HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb2uzk.pdb AC BDEF 0
Biounits:
2uzk.pdb1.pdb A BE 1
2uzk.pdb2.pdb C DF 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Forkhead Domain O43524_158-245 5.4e-27 1 CL0123 A 158 245 BE  H-Bb H-Mj S-Bb 
Forkhead Domain O43524_158-245 4.3e-27 1 CL0123 C 1158 1245 DF  H-Bb H-Mj S-Bb 
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
A/C=158-253 C cytoplasm
A/C=158-253 C cytosol
A/C=158-253 C mitochondrial matrix
A/C=158-253 C mitochondrial outer membrane
A/C=158-253 C nuclear chromatin
A/C=158-253 C nucleoplasm
A/C=158-253 C nucleus
A/C=158-253 C protein-containing complex
A/C=158-253 F beta-catenin binding
A/C=158-253 F chromatin DNA binding
A/C=158-253 F DNA binding
A/C=158-253 F DNA-binding transcription activator activity, RNA polymerase II-specific
A/C=158-253 F DNA-binding transcription factor activity
A/C=158-253 F DNA-binding transcription factor activity, RNA polymerase II-specific
A/C=158-253 F DNA-binding transcription repressor activity, RNA polymerase II-specific
A/C=158-253 F mitochondrial sequence-specific DNA-binding transcription factor activity
A/C=158-253 F protein kinase binding
A/C=158-253 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
A/C=158-253 F sequence-specific DNA binding
A/C=158-253 F sequence-specific double-stranded DNA binding
A/C=158-253 F transcription cofactor binding
A/C=158-253 F transcription factor binding
A/C=158-253 F transcription regulatory region sequence-specific DNA binding
A/C=158-253 P aging
A/C=158-253 P antral ovarian follicle growth
A/C=158-253 P brain morphogenesis
A/C=158-253 P cellular response to amyloid-beta
A/C=158-253 P cellular response to corticosterone stimulus
A/C=158-253 P cellular response to glucose starvation
A/C=158-253 P cellular response to glucose stimulus
A/C=158-253 P cellular response to hypoxia
A/C=158-253 P cellular response to nerve growth factor stimulus
A/C=158-253 P cellular response to oxidative stress
A/C=158-253 P cytokine-mediated signaling pathway
A/C=158-253 P DNA damage response, signal transduction by p53 class mediator
A/C=158-253 P extrinsic apoptotic signaling pathway in absence of ligand
A/C=158-253 P glucose homeostasis
A/C=158-253 P initiation of primordial ovarian follicle growth
A/C=158-253 P insulin receptor signaling pathway
A/C=158-253 P mitochondrial transcription
A/C=158-253 P negative regulation of canonical Wnt signaling pathway
A/C=158-253 P negative regulation of cell migration
A/C=158-253 P negative regulation of neuron differentiation
A/C=158-253 P negative regulation of transcription by RNA polymerase II
A/C=158-253 P neuronal stem cell population maintenance
A/C=158-253 P oocyte maturation
A/C=158-253 P ovulation from ovarian follicle
A/C=158-253 P positive regulation of apoptotic process
A/C=158-253 P positive regulation of autophagy
A/C=158-253 P positive regulation of endothelial cell apoptotic process
A/C=158-253 P positive regulation of erythrocyte differentiation
A/C=158-253 P positive regulation of hydrogen peroxide-mediated programmed cell death
A/C=158-253 P positive regulation of muscle atrophy
A/C=158-253 P positive regulation of neuron apoptotic process
A/C=158-253 P positive regulation of pri-miRNA transcription by RNA polymerase II
A/C=158-253 P positive regulation of reactive oxygen species biosynthetic process
A/C=158-253 P positive regulation of transcription by RNA polymerase II
A/C=158-253 P positive regulation of transcription, DNA-templated
A/C=158-253 P regulation of neural precursor cell proliferation
A/C=158-253 P regulation of transcription by RNA polymerase II
A/C=158-253 P regulation of translation
A/C=158-253 P response to dexamethasone
A/C=158-253 P response to drug
A/C=158-253 P response to fatty acid
A/C=158-253 P response to starvation
A/C=158-253 P response to water-immersion restraint stress
A/C=158-253 P tumor necrosis factor-mediated signaling pathway
Sequences
Download file with secondary structure created by Stride  
2uzk.pdb1.pdb:   [ download sequences in FASTA format ]
B (dna): 
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E (dna): 
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A (protein): 
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2uzk.pdb2.pdb:   [ download sequences in FASTA format ]
D (dna): 
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F (dna): 
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C (protein): 
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