General information
PDB ID 3E00
Title INTACT PPAR GAMMA - RXR ALPHA NUCLEAR RECEPTOR COMPLEX ON DNA BOUND WITH GW9662, 9-CIS RETINOIC ACID AND NCOA2 PEPTIDE
PDB header TRANSCRIPTION/DNA
Date 2008-07-30
Experimental method X-RAY DIFFRACTION
Resolution (A) 3.1
Kind dna
Organism HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb3e00.pdb ADGE CF 0
Biounits:
3e00.pdb1.pdb ADGE CF 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Hormone_recep Domain P19793_263-442 2.1e-40 1 No_clan A 237 442   
zf-C4 Domain P19793_133-202 3e-32 1 CL0167 A 133 202 CF  H-Bb H-Mj L-Bb 
zf-C4 Domain P37231_137-205 1.8e-27 1 CL0167 D 109 177 CF  H-Bb H-Mj S-Bb L-Bb 
Hormone_recep Domain P37231_304-486 2.4e-16 1 No_clan D 285 458   
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
A=11-462 C nucleoplasm
A=11-462 C axon
A=11-462 C nuclear chromatin
A=11-462 F transcription coactivator activity
A=11-462 F double-stranded DNA binding
A=11-462 F sequence-specific DNA binding
A=11-462 F steroid hormone receptor activity
A=11-462 F chromatin DNA binding
A=11-462 F retinoic acid-responsive element binding
A=11-462 F zinc ion binding
A=11-462 F 9-cis retinoic acid receptor activity
A=11-462 P regulation of branching involved in prostate gland morphogenesis
A=11-462 P secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
A=11-462 P ventricular cardiac muscle cell differentiation
A=11-462 P vitamin metabolic process
A=11-462 P positive regulation of transcription from RNA polymerase II promoter
A=11-462 P response to glucocorticoid stimulus
A=11-462 P negative regulation of transcription from RNA polymerase II promoter
A=11-462 P ventricular cardiac muscle tissue morphogenesis
A=11-462 P peroxisome proliferator activated receptor signaling pathway
A=11-462 P response to organic cyclic compound
A=11-462 P midgut development
A=11-462 P liver development
A=11-462 P placenta development
A=11-462 P response to retinoic acid
A=11-462 P female pregnancy
A=11-462 P cholesterol metabolic process
A=11-462 P response to ethanol
A=11-462 P positive regulation of apoptotic process
A=11-462 P transcription initiation from RNA polymerase II promoter
A=11-462 P virus-host interaction
A=11-462 P inflammatory response
A=11-462 P cellular lipid metabolic process
A=11-462 P response to vitamin D
A=11-462 P cardiac muscle cell proliferation
A=11-462 P response to selenium ion
A=11-462 P negative regulation of cell proliferation
A=11-462 P axon regeneration
A=11-462 P aging
A=11-462 P cellular response to insulin stimulus
D=102-505 C cytosol
D=102-505 F transcription regulatory region DNA binding
D=102-505 F prostaglandin receptor activity
D=102-505 F arachidonic acid binding
D=102-505 F drug binding
D=102-505 F ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
D=102-505 F RNA polymerase II regulatory region DNA binding
D=102-505 P positive regulation of oligodendrocyte differentiation
D=102-505 P innate immune response
D=102-505 P lipoprotein transport
D=102-505 P negative regulation of receptor biosynthetic process
D=102-505 P negative regulation of sequestering of triglyceride
D=102-505 P epithelial cell differentiation
D=102-505 P cell fate commitment
D=102-505 P positive regulation of sequence-specific DNA binding transcription factor activity
D=102-505 P negative regulation of telomerase activity
D=102-505 P response to low-density lipoprotein particle stimulus
D=102-505 P brown fat cell differentiation
D=102-505 P positive regulation of fatty acid oxidation
D=102-505 P negative regulation of interferon-gamma-mediated signaling pathway
D=102-505 P low-density lipoprotein particle receptor biosynthetic process
D=102-505 P response to drug
D=102-505 P lipid metabolic process
D=102-505 P cell maturation
D=102-505 P organ regeneration
D=102-505 P response to nutrient
D=102-505 P glucose homeostasis
D=102-505 P heart development
D=102-505 P response to cold
D=102-505 P lipid homeostasis
D=102-505 P response to caffeine
D=102-505 P cellular response to organic cyclic compound
D=102-505 P response to vitamin A
D=102-505 P response to lipid
D=102-505 P negative regulation of macrophage derived foam cell differentiation
D=102-505 P activation of cysteine-type endopeptidase activity involved in apoptotic process
D=102-505 P negative regulation of cholesterol storage
D=102-505 P fatty acid oxidation
D=102-505 P induction of apoptosis
D=102-505 P response to estrogen stimulus
D=102-505 P cellular response to lithium ion
D=102-505 P regulation of cholesterol transporter activity
D=102-505 P positive regulation of fat cell differentiation
D=102-505 P monocyte differentiation
D=102-505 P long-chain fatty acid transport
D=102-505 P white fat cell differentiation
D=102-505 P negative regulation of cell growth
D=102-505 P negative regulation of acute inflammatory response
D=102-505 P negative regulation of smooth muscle cell proliferation
D=102-505 P regulation of blood pressure
E/G=685-697 C rough endoplasmic reticulum
E/G=685-697 C neuronal cell body
E/G=685-697 C presynaptic active zone
E/G=685-697 C postsynaptic density
E/G=685-697 C Golgi apparatus
E/G=685-697 C microtubule
E/G=685-697 F ligand-dependent nuclear receptor transcription coactivator activity
E/G=685-697 F histone acetyltransferase activity
E/G=685-697 F signal transducer activity
E/G=685-697 F thyroid hormone receptor coactivator activity
E/G=685-697 F chromatin binding
E/G=685-697 P histone acetylation
E/G=685-697 P regulation of transcription, DNA-dependent
E/G=685-697 P transcription, DNA-dependent
E/G=685-697 P small molecule metabolic process
E/G=685-697 P cerebellum development
Sequences
Download file with secondary structure created by Stride  
3e00.pdb1.pdb:   [ download sequences in FASTA format ]
C (dna): 
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F (dna): 
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A (protein): 
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D (protein): 
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E (protein): 
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G (protein): 
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