General information
PDB ID 3KLE
Title CRYSTAL STRUCTURE OF AZT-RESISTANT HIV-1 REVERSE TRANSCRIPTASE CROSSLINKED TO A DSDNA WITH A BOUND EXCISION PRODUCT, AZTPPPPA
PDB header TRANSFERASE/DNA
Date 2009-11-07
Experimental method X-RAY DIFFRACTION
Resolution (A) 3.2
Kind dna
Organism HUMAN IMMUNODEFICIENCY VIRUS TYPE 1
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb3kle.pdb ABEFIJMN CDGHKLOP 0
Biounits:
3kle.pdb1.pdb AB CD 1
3kle.pdb2.pdb EF GH 1
3kle.pdb3.pdb IJ KL 1
3kle.pdb4.pdb MN OP 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
RVT_connect Domain P03366_917-1018 2.5e-59 1 No_clan A 318 419 D  S-Bb 
RVT_1 Domain P03366_662-833 1.3e-33 1 CL0027 A 63 234 CD  S-Bb L-Bb L-Mn 
RNase_H Domain P03366_1035-1153 5.6e-29 1 CL0219 A 436 557 CD  H-Bb L-Bb L-Mn 
RVT_thumb Domain P03366_840-903 1.1e-19 1 No_clan A 241 304 CD  H-Bb L-Bb 
RVT_connect Domain P03366_917-1018 1.6e-59 1 No_clan B 318 419   
RVT_1 Domain P03366_662-833 5.4e-35 1 CL0027 B 63 263   
RVT_thumb Domain P03366_840-903 1.5e-21 1 No_clan B 241 304   
RVT_connect Domain P03366_917-1018 2.5e-59 1 No_clan E 318 419 H  S-Bb 
RVT_1 Domain P03366_662-833 1.3e-33 1 CL0027 E 63 234 GH  S-Bb L-Bb L-Mn 
RNase_H Domain P03366_1035-1153 5.6e-29 1 CL0219 E 436 557 GH  H-Bb L-Bb L-Mn 
RVT_thumb Domain P03366_840-903 1.1e-19 1 No_clan E 241 304 GH  H-Bb L-Bb 
RVT_connect Domain P03366_917-1018 1.5e-59 1 No_clan F 318 419   
RVT_1 Domain P03366_662-833 5.3e-35 1 CL0027 F 63 263   
RVT_thumb Domain P03366_840-903 1.4e-21 1 No_clan F 241 304   
RVT_connect Domain P03366_917-1018 2.5e-59 1 No_clan I 318 419 L  S-Bb L-Bb 
RVT_1 Domain P03366_662-833 1.3e-33 1 CL0027 I 63 234 KL  S-Bb L-Bb 
RNase_H Domain P03366_1035-1153 5.6e-29 1 CL0219 I 436 557 KL  H-Bb L-Bb L-Mn 
RVT_thumb Domain P03366_840-903 1.1e-19 1 No_clan I 241 304 KL  H-Bb L-Bb 
RVT_connect Domain P03366_917-1018 1.5e-59 1 No_clan J 318 419   
RVT_1 Domain P03366_662-833 5.3e-35 1 CL0027 J 63 263   
RVT_thumb Domain P03366_840-903 1.4e-21 1 No_clan J 241 304   
RVT_connect Domain P03366_917-1018 2.5e-59 1 No_clan M 318 419 P  S-Bb 
RVT_1 Domain P03366_662-833 1.3e-33 1 CL0027 M 63 234 PO  S-Bb S-Mn L-Bb L-Mn 
RNase_H Domain P03366_1035-1153 5.6e-29 1 CL0219 M 436 557 OP  H-Bb L-Bb L-Mn 
RVT_thumb Domain P03366_840-903 1.1e-19 1 No_clan M 241 304 OP  H-Bb L-Bb 
RVT_connect Domain P03366_917-1018 1.5e-59 1 No_clan N 318 419   
RVT_1 Domain P03366_662-833 5.3e-35 1 CL0027 N 63 263   
RVT_thumb Domain P03366_840-903 1.4e-21 1 No_clan N 241 304   
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
A/E/I/M=600-1157, B/F/J/N=600-1027 C host cell nucleus
A/E/I/M=600-1157, B/F/J/N=600-1027 C host cell plasma membrane
A/E/I/M=600-1157, B/F/J/N=600-1027 C host multivesicular body
A/E/I/M=600-1157, B/F/J/N=600-1027 C viral nucleocapsid
A/E/I/M=600-1157, B/F/J/N=600-1027 C virion membrane
A/E/I/M=600-1157, B/F/J/N=600-1027 F aspartic-type endopeptidase activity
A/E/I/M=600-1157, B/F/J/N=600-1027 F DNA binding
A/E/I/M=600-1157, B/F/J/N=600-1027 F DNA-directed DNA polymerase activity
A/E/I/M=600-1157, B/F/J/N=600-1027 F exoribonuclease H activity
A/E/I/M=600-1157, B/F/J/N=600-1027 F lipid binding
A/E/I/M=600-1157, B/F/J/N=600-1027 F RNA binding
A/E/I/M=600-1157, B/F/J/N=600-1027 F RNA-directed DNA polymerase activity
A/E/I/M=600-1157, B/F/J/N=600-1027 F RNA-DNA hybrid ribonuclease activity
A/E/I/M=600-1157, B/F/J/N=600-1027 F structural molecule activity
A/E/I/M=600-1157, B/F/J/N=600-1027 F zinc ion binding
A/E/I/M=600-1157, B/F/J/N=600-1027 P DNA integration
A/E/I/M=600-1157, B/F/J/N=600-1027 P DNA recombination
A/E/I/M=600-1157, B/F/J/N=600-1027 P establishment of integrated proviral latency
A/E/I/M=600-1157, B/F/J/N=600-1027 P induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process
A/E/I/M=600-1157, B/F/J/N=600-1027 P suppression by virus of host gene expression
A/E/I/M=600-1157, B/F/J/N=600-1027 P viral entry into host cell
A/E/I/M=600-1157, B/F/J/N=600-1027 P viral genome integration into host DNA
A/E/I/M=600-1157, B/F/J/N=600-1027 P viral penetration into host nucleus
Sequences
Download file with secondary structure created by Stride  
3kle.pdb1.pdb:   [ download sequences in FASTA format ]
C (dna): 
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D (dna): 
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A (protein): 
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B (protein): 
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3kle.pdb2.pdb:   [ download sequences in FASTA format ]
G (dna): 
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H (dna): 
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E (protein): 
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F (protein): 
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3kle.pdb3.pdb:   [ download sequences in FASTA format ]
K (dna): 
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L (dna): 
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I (protein): 
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J (protein): 
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3kle.pdb4.pdb:   [ download sequences in FASTA format ]
O (dna): 
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P (dna): 
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M (protein): 
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N (protein): 
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