General information
PDB ID 3NBN
Title CRYSTAL STRUCTURE OF A DIMER OF NOTCH TRANSCRIPTION COMPLEX TRIMERS ON HES1 DNA
PDB header TRANSCRIPTION/DNA
Date 2010-06-03
Experimental method X-RAY DIFFRACTION
Resolution (A) 3.45
Kind dna
Organism HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb3nbn.pdb ABCDEF XY 0
Biounits:
3nbn.pdb1.pdb ABCDEF XY 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
BTD Domain Q06330_179-328 6.5e-75 1 CL0066 A 165 314 XY  S-Bb S-Mn L-Bb 
LAG1-DNAbind Domain Q06330_48-178 8.9e-51 1 CL0073 A 34 164 XY  L-Bb L-Mj 
MamL-1 Domain Q92585_16-70 2e-27 1 No_clan C 16 70   
BTD Domain Q06330_179-328 6.5e-75 1 CL0066 D 165 314 Y   
LAG1-DNAbind Domain Q06330_48-178 8.9e-51 1 CL0073 D 34 164 XY   
MamL-1 Domain Q92585_16-70 2e-27 1 No_clan F 16 70   
Ank_2 Repeat P46531_1999-2092 0.00000000000035 1 CL0465 B 2000 2092   
Ank_2 Repeat P46531_1971-2058 0.00000000014 1 CL0465 B 1924 1993   
Ank_2 Repeat P46531_1999-2092 0.00000000000035 1 CL0465 E 2000 2092   
Ank_2 Repeat P46531_1971-2058 0.00000000014 1 CL0465 E 1924 1993   
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
A/D=23-448 C cytoplasm
A/D=23-448 C nucleolus
A/D=23-448 F DNA binding
A/D=23-448 F RNA polymerase II core promoter proximal region sequence-specific DNA binding
A/D=23-448 F recombinase activity
A/D=23-448 F RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
A/D=23-448 P outflow tract morphogenesis
A/D=23-448 P DNA recombination
B/E=1872-2126 C MAML1-RBP-Jkappa- ICN1 complex
B/E=1872-2126 C Golgi membrane
B/E=1872-2126 C integral to membrane
B/E=1872-2126 C acrosomal vesicle
B/E=1872-2126 C plasma membrane
B/E=1872-2126 C nucleoplasm
B/E=1872-2126 C endoplasmic reticulum membrane
B/E=1872-2126 F enzyme inhibitor activity
B/E=1872-2126 F core promoter binding
B/E=1872-2126 F calcium ion binding
B/E=1872-2126 F receptor activity
B/E=1872-2126 F sequence-specific DNA binding transcription factor activity
B/E=1872-2126 P negative regulation of myotube differentiation
B/E=1872-2126 P negative regulation of anoikis
B/E=1872-2126 P cardiac chamber formation
B/E=1872-2126 P growth involved in heart morphogenesis
B/E=1872-2126 P transcription initiation from RNA polymerase II promoter
B/E=1872-2126 P immune response
B/E=1872-2126 P positive regulation of transcription of Notch receptor target
B/E=1872-2126 P aortic valve morphogenesis
B/E=1872-2126 P response to muramyl dipeptide
B/E=1872-2126 P regulation of cardioblast proliferation
B/E=1872-2126 P positive regulation of cardiac muscle cell proliferation
B/E=1872-2126 P negative regulation of ossification
B/E=1872-2126 P coronary artery morphogenesis
B/E=1872-2126 P ventricular trabecula myocardium morphogenesis
B/E=1872-2126 P pericardium morphogenesis
B/E=1872-2126 P negative regulation of myoblast differentiation
B/E=1872-2126 P positive regulation of neuroblast proliferation
B/E=1872-2126 P positive regulation of BMP signaling pathway
B/E=1872-2126 P regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
B/E=1872-2126 P venous endothelial cell differentiation
B/E=1872-2126 P organ regeneration
B/E=1872-2126 P negative regulation of glial cell proliferation
B/E=1872-2126 P cell differentiation in spinal cord
B/E=1872-2126 P negative regulation of osteoblast differentiation
B/E=1872-2126 P negative regulation of stem cell differentiation
B/E=1872-2126 P heart looping
B/E=1872-2126 P neuronal stem cell maintenance
B/E=1872-2126 P vasculogenesis involved in coronary vascular morphogenesis
B/E=1872-2126 P oligodendrocyte differentiation
B/E=1872-2126 P response to corticosteroid stimulus
B/E=1872-2126 P cardiac left ventricle morphogenesis
B/E=1872-2126 P collecting duct development
B/E=1872-2126 P positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
B/E=1872-2126 P positive regulation of epithelial to mesenchymal transition
B/E=1872-2126 P regulation of extracellular matrix assembly
B/E=1872-2126 P positive regulation of JAK-STAT cascade
B/E=1872-2126 P positive regulation of cell migration
B/E=1872-2126 P distal tubule development
B/E=1872-2126 P Notch receptor processing
B/E=1872-2126 P positive regulation of astrocyte differentiation
B/E=1872-2126 P endocardium morphogenesis
B/E=1872-2126 P negative regulation of pro-B cell differentiation
B/E=1872-2126 P negative regulation of oligodendrocyte differentiation
B/E=1872-2126 P coronary vein morphogenesis
B/E=1872-2126 P negative regulation of cell-substrate adhesion
B/E=1872-2126 P astrocyte differentiation
B/E=1872-2126 P epithelial to mesenchymal transition involved in endocardial cushion formation
B/E=1872-2126 P response to lipopolysaccharide
B/E=1872-2126 P endocardial cell differentiation
B/E=1872-2126 P glomerular mesangial cell development
B/E=1872-2126 P cardiac septum morphogenesis
B/E=1872-2126 P negative regulation of neuron differentiation
B/E=1872-2126 P negative regulation of transcription from RNA polymerase II promoter
B/E=1872-2126 P spermatogenesis
B/E=1872-2126 P tissue regeneration
B/E=1872-2126 P atrioventricular valve morphogenesis
B/E=1872-2126 P positive regulation of endothelial cell differentiation
B/E=1872-2126 P cardiac vascular smooth muscle cell development
B/E=1872-2126 P arterial endothelial cell differentiation
B/E=1872-2126 P negative regulation of BMP signaling pathway
B/E=1872-2126 P cardiac right atrium morphogenesis
B/E=1872-2126 P Notch signaling involved in heart development
C/F=13-74 C nuclear speck
C/F=13-74 F peptide antigen binding
C/F=13-74 F transcription coactivator activity
C/F=13-74 P positive regulation of myotube differentiation
C/F=13-74 P atrioventricular node cell development
C/F=13-74 P myoblast differentiation
C/F=13-74 P protein phosphorylation
C/F=13-74 P positive regulation of transcription from RNA polymerase II promoter
C/F=13-74 P Notch signaling pathway
Sequences
Download file with secondary structure created by Stride  
3nbn.pdb1.pdb:   [ download sequences in FASTA format ]
X (dna): 
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Y (dna): 
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A (protein): 
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B (protein): 
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C (protein): 
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D (protein): 
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E (protein): 
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F (protein): 
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