General information
PDB ID 3PTA
Title CRYSTAL STRUCTURE OF HUMAN DNMT1(646-1600) IN COMPLEX WITH DNA
PDB header TRANSFERASE/DNA
Date 2010-12-02
Experimental method X-RAY DIFFRACTION
Resolution (A) 3.6
Kind dna
Organism HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb3pta.pdb A BC 0
Biounits:
3pta.pdb1.pdb A BC 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
DNA_methylase Domain P26358_1139-1594 8.7e-48 1 CL0063 A 1139 1594 B  L-Bb 
BAH Domain P26358_931-1100 1.3e-23 1 No_clan A 931 1100   
BAH Domain P26358_755-880 2.4e-23 1 No_clan A 755 880   
zf-CXXC Domain P26358_647-691 2.7e-14 1 No_clan A 647 691 BC  L-Bb L-Mj 
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
A=646-1600 C nucleoplasm
A=646-1600 C nucleus
A=646-1600 C pericentric heterochromatin
A=646-1600 C replication fork
A=646-1600 F DNA (cytosine-5-)-methyltransferase activity
A=646-1600 F DNA binding
A=646-1600 F DNA-methyltransferase activity
A=646-1600 F methyl-CpG binding
A=646-1600 F promoter-specific chromatin binding
A=646-1600 F RNA binding
A=646-1600 F zinc ion binding
A=646-1600 P cellular response to amino acid stimulus
A=646-1600 P chromatin organization
A=646-1600 P DNA methylation
A=646-1600 P DNA methylation involved in embryo development
A=646-1600 P gene silencing
A=646-1600 P maintenance of DNA methylation
A=646-1600 P negative regulation of gene expression
A=646-1600 P negative regulation of gene expression, epigenetic
A=646-1600 P negative regulation of histone H3-K9 methylation
A=646-1600 P negative regulation of transcription by RNA polymerase II
A=646-1600 P negative regulation of vascular associated smooth muscle cell apoptotic process
A=646-1600 P negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching
A=646-1600 P positive regulation of DNA methylation-dependent heterochromatin assembly
A=646-1600 P positive regulation of gene expression
A=646-1600 P positive regulation of histone H3-K4 methylation
A=646-1600 P positive regulation of vascular associated smooth muscle cell proliferation
A=646-1600 P Ras protein signal transduction
Sequences
Download file with secondary structure created by Stride  
3pta.pdb1.pdb:   [ download sequences in FASTA format ]
B (dna): 
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C (dna): 
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A (protein): 
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