General information
PDB ID 3Q05
Title AN INDUCED FIT MECHANISM REGULATES P53 DNA BINDING KINETICS TO CONFER SEQUENCE SPECIFICITY
PDB header ANTITUMOR PROTEIN/DNA
Date 2010-12-15
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.4
Kind dna
Organism HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
 PDIdb 
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb3q05.pdb ACDB KL 0
Biounits:
3q05.pdb1.pdb ACDB KL 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
P53 Domain P04637_99-289 3.9e-110 1 CL0073 A 95 289 KL  H-Bb H-Mj S-Bb L-Bb L-Mj 
P53 Domain P04637_99-289 3.9e-110 1 CL0073 B 95 289 KL  H-Mj S-Bb L-Bb L-Mj 
P53 Domain P04637_99-289 3.9e-110 1 CL0073 C 95 289 KL  H-Mj S-Bb L-Bb L-Mj 
P53 Domain P04637_99-289 3.9e-110 1 CL0073 D 95 289 KL  H-Bb H-Mj S-Bb L-Bb L-Mj 
P53_tetramer Motif P04637_322-356 0.000000000000071 1 No_clan A 290 356   
P53_tetramer Motif P04637_322-356 0.000000000000071 1 No_clan B 290 356   
P53_tetramer Motif P04637_322-356 0.000000000000071 1 No_clan C 290 356   
P53_tetramer Motif P04637_322-356 0.000000000000071 1 No_clan D 290 356   
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
A/B/C/D=94-355 C cytoplasm
A/B/C/D=94-355 C nuclear chromatin
A/B/C/D=94-355 C PML body
A/B/C/D=94-355 C cytosol
A/B/C/D=94-355 C mitochondrion
A/B/C/D=94-355 C nuclear matrix
A/B/C/D=94-355 C nucleus
A/B/C/D=94-355 C chromatin assembly complex
A/B/C/D=94-355 C endoplasmic reticulum
A/B/C/D=94-355 C nucleolus
A/B/C/D=94-355 C replication fork
A/B/C/D=94-355 F DNA strand annealing activity
A/B/C/D=94-355 F histone deacetylase regulator activity
A/B/C/D=94-355 F chromatin binding
A/B/C/D=94-355 F damaged DNA binding
A/B/C/D=94-355 F RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
A/B/C/D=94-355 F copper ion binding
A/B/C/D=94-355 F RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
A/B/C/D=94-355 F ATP binding
A/B/C/D=94-355 F zinc ion binding
A/B/C/D=94-355 F transcription regulatory region DNA binding
A/B/C/D=94-355 P positive regulation of peptidyl-tyrosine phosphorylation
A/B/C/D=94-355 P positive regulation of intrinsic apoptotic signaling pathway
A/B/C/D=94-355 P T cell proliferation involved in immune response
A/B/C/D=94-355 P positive regulation of histone deacetylation
A/B/C/D=94-355 P negative regulation of fibroblast proliferation
A/B/C/D=94-355 P nucleotide-excision repair
A/B/C/D=94-355 P positive regulation of cell aging
A/B/C/D=94-355 P negative regulation of helicase activity
A/B/C/D=94-355 P determination of adult lifespan
A/B/C/D=94-355 P positive regulation of release of cytochrome c from mitochondria
A/B/C/D=94-355 P negative regulation of transforming growth factor beta receptor signaling pathway
A/B/C/D=94-355 P virus-host interaction
A/B/C/D=94-355 P negative regulation of transcription from RNA polymerase II promoter
A/B/C/D=94-355 P positive regulation of reactive oxygen species metabolic process
A/B/C/D=94-355 P release of cytochrome c from mitochondria
A/B/C/D=94-355 P protein tetramerization
A/B/C/D=94-355 P positive regulation of protein oligomerization
A/B/C/D=94-355 P chromosome organization
A/B/C/D=94-355 P DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
A/B/C/D=94-355 P transforming growth factor beta receptor signaling pathway
A/B/C/D=94-355 P response to antibiotic
A/B/C/D=94-355 P replicative senescence
A/B/C/D=94-355 P cellular response to drug
A/B/C/D=94-355 P DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
A/B/C/D=94-355 P negative regulation of apoptotic process
A/B/C/D=94-355 P response to X-ray
A/B/C/D=94-355 P neuron apoptotic process
A/B/C/D=94-355 P Ras protein signal transduction
A/B/C/D=94-355 P negative regulation of neuroblast proliferation
A/B/C/D=94-355 P base-excision repair
A/B/C/D=94-355 P cellular response to ionizing radiation
A/B/C/D=94-355 P T cell differentiation in thymus
A/B/C/D=94-355 P cell differentiation
A/B/C/D=94-355 P multicellular organism growth
A/B/C/D=94-355 P positive regulation of neuron apoptotic process
A/B/C/D=94-355 P cellular response to UV
A/B/C/D=94-355 P protein localization
A/B/C/D=94-355 P cellular response to hypoxia
A/B/C/D=94-355 P response to salt stress
A/B/C/D=94-355 P protein import into nucleus, translocation
A/B/C/D=94-355 P in utero embryonic development
A/B/C/D=94-355 P T cell lineage commitment
A/B/C/D=94-355 P oxidative stress-induced premature senescence
A/B/C/D=94-355 P cellular response to glucose starvation
A/B/C/D=94-355 P B cell lineage commitment
A/B/C/D=94-355 P positive regulation of transcription from RNA polymerase II promoter
A/B/C/D=94-355 P blood coagulation
A/B/C/D=94-355 P negative regulation of DNA replication
A/B/C/D=94-355 P cellular protein localization
A/B/C/D=94-355 P mitotic cell cycle arrest
A/B/C/D=94-355 P apoptotic process
A/B/C/D=94-355 P central nervous system development
A/B/C/D=94-355 P regulation of mitochondrial membrane permeability
A/B/C/D=94-355 P double-strand break repair
A/B/C/D=94-355 P gastrulation
A/B/C/D=94-355 P somitogenesis
A/B/C/D=94-355 P response to gamma radiation
A/B/C/D=94-355 P ER overload response
A/B/C/D=94-355 P negative regulation of cell growth
A/B/C/D=94-355 P cell proliferation
A/B/C/D=94-355 P DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
A/B/C/D=94-355 P cell cycle arrest
A/B/C/D=94-355 P rRNA transcription
A/B/C/D=94-355 P positive regulation of thymocyte apoptotic process
Sequences
Download file with secondary structure created by Stride  
3q05.pdb1.pdb:   [ download sequences in FASTA format ]
K (dna): 
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L (dna): 
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A (protein): 
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B (protein): 
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C (protein): 
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D (protein): 
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