General information
PDB ID 3QRF
Title STRUCTURE OF A DOMAIN-SWAPPED FOXP3 DIMER
PDB header DNA BINDING PROTEIN/DNA
Date 2011-02-17
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.8
Kind dna
Organism HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb3qrf.pdb NFGMHI CDAB 0
Biounits:
3qrf.pdb1.pdb NFG CD 1
3qrf.pdb2.pdb MHI AB 2
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Forkhead Domain Q9BZS1_336-417 7e-28 1 CL0123 F 336 417 C  H-Bb H-Mj 
Forkhead Domain Q9BZS1_336-417 7e-28 1 CL0123 G 336 417 CD  H-Bb H-Mj S-Bb 
RHD_dimer Domain Q13469_579-678 5.4e-25 1 CL0159 N 579 678   
RHD_DNA_bind Domain Q13469_410-570 5.6e-23 1 CL0073 N 410 570 CD  H-Bb S-Bb S-Mj L-Bb L-Mj 
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
F/G/H/I=336-417 C cytoplasm
F/G/H/I=336-417 C nuclear chromatin
F/G/H/I=336-417 C nucleoplasm
F/G/H/I=336-417 C nucleus
F/G/H/I=336-417 C protein-containing complex
F/G/H/I=336-417 F DNA binding
F/G/H/I=336-417 F DNA-binding transcription factor activity
F/G/H/I=336-417 F DNA-binding transcription factor activity, RNA polymerase II-specific
F/G/H/I=336-417 F histone acetyltransferase binding
F/G/H/I=336-417 F histone deacetylase binding
F/G/H/I=336-417 F metal ion binding
F/G/H/I=336-417 F NF-kappaB binding
F/G/H/I=336-417 F NFAT protein binding
F/G/H/I=336-417 F protein homodimerization activity
F/G/H/I=336-417 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
F/G/H/I=336-417 F sequence-specific DNA binding
F/G/H/I=336-417 F sequence-specific double-stranded DNA binding
F/G/H/I=336-417 F transcription corepressor activity
F/G/H/I=336-417 P B cell homeostasis
F/G/H/I=336-417 P CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment
F/G/H/I=336-417 P chromatin remodeling
F/G/H/I=336-417 P cytokine production
F/G/H/I=336-417 P myeloid cell homeostasis
F/G/H/I=336-417 P negative regulation of activated T cell proliferation
F/G/H/I=336-417 P negative regulation of cell population proliferation
F/G/H/I=336-417 P negative regulation of chronic inflammatory response
F/G/H/I=336-417 P negative regulation of CREB transcription factor activity
F/G/H/I=336-417 P negative regulation of cytokine biosynthetic process
F/G/H/I=336-417 P negative regulation of cytokine secretion
F/G/H/I=336-417 P negative regulation of DNA-binding transcription factor activity
F/G/H/I=336-417 P negative regulation of histone acetylation
F/G/H/I=336-417 P negative regulation of histone deacetylation
F/G/H/I=336-417 P negative regulation of immune response
F/G/H/I=336-417 P negative regulation of interferon-gamma production
F/G/H/I=336-417 P negative regulation of interleukin-10 production
F/G/H/I=336-417 P negative regulation of interleukin-17 production
F/G/H/I=336-417 P negative regulation of interleukin-2 production
F/G/H/I=336-417 P negative regulation of interleukin-4 production
F/G/H/I=336-417 P negative regulation of interleukin-5 production
F/G/H/I=336-417 P negative regulation of interleukin-6 production
F/G/H/I=336-417 P negative regulation of isotype switching to IgE isotypes
F/G/H/I=336-417 P negative regulation of NF-kappaB transcription factor activity
F/G/H/I=336-417 P negative regulation of T cell cytokine production
F/G/H/I=336-417 P negative regulation of T cell proliferation
F/G/H/I=336-417 P negative regulation of T-helper 17 cell differentiation
F/G/H/I=336-417 P negative regulation of transcription by RNA polymerase II
F/G/H/I=336-417 P negative regulation of transcription, DNA-templated
F/G/H/I=336-417 P negative regulation of tumor necrosis factor production
F/G/H/I=336-417 P positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
F/G/H/I=336-417 P positive regulation of histone acetylation
F/G/H/I=336-417 P positive regulation of immature T cell proliferation in thymus
F/G/H/I=336-417 P positive regulation of interleukin-4 production
F/G/H/I=336-417 P positive regulation of peripheral T cell tolerance induction
F/G/H/I=336-417 P positive regulation of T cell anergy
F/G/H/I=336-417 P positive regulation of transcription by RNA polymerase II
F/G/H/I=336-417 P positive regulation of transcription, DNA-templated
F/G/H/I=336-417 P positive regulation of transforming growth factor beta1 production
F/G/H/I=336-417 P regulation of isotype switching to IgG isotypes
F/G/H/I=336-417 P regulation of regulatory T cell differentiation
F/G/H/I=336-417 P regulation of T cell anergy
F/G/H/I=336-417 P regulation of transcription, DNA-templated
F/G/H/I=336-417 P regulation of Wnt signaling pathway
F/G/H/I=336-417 P response to virus
F/G/H/I=336-417 P T cell activation
F/G/H/I=336-417 P T cell homeostasis
F/G/H/I=336-417 P T cell mediated immunity
F/G/H/I=336-417 P T cell receptor signaling pathway
F/G/H/I=336-417 P tolerance induction to self antigen
M/N=396-678 C cytoplasm
M/N=396-678 C cytosol
M/N=396-678 C nuclear chromatin
M/N=396-678 C nucleoplasm
M/N=396-678 C nucleus
M/N=396-678 C ribonucleoprotein complex
M/N=396-678 C transcription regulator complex
M/N=396-678 F chromatin binding
M/N=396-678 F DNA binding
M/N=396-678 F DNA-binding transcription activator activity, RNA polymerase II-specific
M/N=396-678 F DNA-binding transcription factor activity
M/N=396-678 F DNA-binding transcription factor activity, RNA polymerase II-specific
M/N=396-678 F DNA-binding transcription repressor activity, RNA polymerase II-specific
M/N=396-678 F phosphatase binding
M/N=396-678 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
M/N=396-678 F sequence-specific double-stranded DNA binding
M/N=396-678 F transcription factor binding
M/N=396-678 P B cell receptor signaling pathway
M/N=396-678 P calcineurin-NFAT signaling cascade
M/N=396-678 P cell migration
M/N=396-678 P cellular response to DNA damage stimulus
M/N=396-678 P cytokine production
M/N=396-678 P Fc-epsilon receptor signaling pathway
M/N=396-678 P myotube cell development
M/N=396-678 P negative regulation of vascular associated smooth muscle cell differentiation
M/N=396-678 P positive regulation of B cell proliferation
M/N=396-678 P positive regulation of myoblast fusion
M/N=396-678 P positive regulation of transcription by RNA polymerase II
M/N=396-678 P positive regulation of transcription, DNA-templated
M/N=396-678 P regulation of regulatory T cell differentiation
M/N=396-678 P regulation of transcription, DNA-templated
M/N=396-678 P response to drug
Sequences
Download file with secondary structure created by Stride  
3qrf.pdb1.pdb:   [ download sequences in FASTA format ]
C (dna): 
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D (dna): 
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F (protein): 
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G (protein): 
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N (protein): 
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3qrf.pdb2.pdb:   [ download sequences in FASTA format ]
A (dna): 
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B (dna): 
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