General information
PDB ID 3RKQ
Title NKX2.5 HOMEODOMAIN DIMER BOUND TO ANF-242 DNA
PDB header TRANSCRIPTION/DNA
Date 2011-04-18
Experimental method X-RAY DIFFRACTION
Resolution (A) 1.7
Kind dna
Organism HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
 PDIdb 
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb3rkq.pdb AB CD 0
Biounits:
3rkq.pdb1.pdb AB CD 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Homeodomain Domain P52952_139-194 2.4e-21 1 CL0123 A 139 194 CD  H-Bb H-Mj L-Bb L-Mn 
Homeodomain Domain P52952_139-194 6.3e-21 1 CL0123 B 139 193 CD  H-Bb H-Mj L-Bb L-Mn 
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
A/B=138-192 C cytoplasm
A/B=138-192 C nuclear chromatin
A/B=138-192 C nucleus
A/B=138-192 C protein-containing complex
A/B=138-192 C protein-DNA complex
A/B=138-192 C RNA polymerase II transcription regulator complex
A/B=138-192 C transcription regulator complex
A/B=138-192 F chromatin binding
A/B=138-192 F DNA binding
A/B=138-192 F DNA-binding transcription activator activity, RNA polymerase II-specific
A/B=138-192 F DNA-binding transcription factor activity
A/B=138-192 F DNA-binding transcription factor activity, RNA polymerase II-specific
A/B=138-192 F protein homodimerization activity
A/B=138-192 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
A/B=138-192 F sequence-specific DNA binding
A/B=138-192 F sequence-specific double-stranded DNA binding
A/B=138-192 F transcription factor binding
A/B=138-192 F transcription regulatory region sequence-specific DNA binding
A/B=138-192 P adult heart development
A/B=138-192 P apoptotic process involved in heart morphogenesis
A/B=138-192 P atrial cardiac muscle cell development
A/B=138-192 P atrial septum morphogenesis
A/B=138-192 P atrioventricular node cell development
A/B=138-192 P atrioventricular node cell fate commitment
A/B=138-192 P bundle of His development
A/B=138-192 P cardiac conduction system development
A/B=138-192 P cardiac muscle cell differentiation
A/B=138-192 P cardiac muscle cell proliferation
A/B=138-192 P cardiac muscle contraction
A/B=138-192 P cardiac muscle tissue morphogenesis
A/B=138-192 P cardiac ventricle formation
A/B=138-192 P cell differentiation
A/B=138-192 P embryonic heart tube development
A/B=138-192 P embryonic heart tube left/right pattern formation
A/B=138-192 P heart looping
A/B=138-192 P heart morphogenesis
A/B=138-192 P heart trabecula formation
A/B=138-192 P hemopoiesis
A/B=138-192 P negative regulation of apoptotic process
A/B=138-192 P negative regulation of canonical Wnt signaling pathway
A/B=138-192 P negative regulation of cardiac muscle cell apoptotic process
A/B=138-192 P negative regulation of myotube differentiation
A/B=138-192 P negative regulation of transcription by RNA polymerase II
A/B=138-192 P negative regulation of transcription, DNA-templated
A/B=138-192 P outflow tract septum morphogenesis
A/B=138-192 P pharyngeal system development
A/B=138-192 P positive regulation of cardioblast differentiation
A/B=138-192 P positive regulation of cell population proliferation
A/B=138-192 P positive regulation of heart contraction
A/B=138-192 P positive regulation of neuron differentiation
A/B=138-192 P positive regulation of sodium ion transport
A/B=138-192 P positive regulation of transcription by RNA polymerase II
A/B=138-192 P positive regulation of transcription initiation from RNA polymerase II promoter
A/B=138-192 P positive regulation of transcription via serum response element binding
A/B=138-192 P positive regulation of transcription, DNA-templated
A/B=138-192 P proepicardium development
A/B=138-192 P pulmonary myocardium development
A/B=138-192 P Purkinje myocyte differentiation
A/B=138-192 P regulation of cardiac conduction
A/B=138-192 P regulation of cardiac muscle cell proliferation
A/B=138-192 P regulation of cardiac muscle contraction
A/B=138-192 P right ventricular cardiac muscle tissue morphogenesis
A/B=138-192 P sarcomere organization
A/B=138-192 P septum secundum development
A/B=138-192 P spleen development
A/B=138-192 P thyroid gland development
A/B=138-192 P vasculogenesis
A/B=138-192 P ventricular cardiac muscle cell development
A/B=138-192 P ventricular cardiac myofibril assembly
A/B=138-192 P ventricular septum morphogenesis
A/B=138-192 P ventricular trabecula myocardium morphogenesis
Sequences
Download file with secondary structure created by Stride  
3rkq.pdb1.pdb:   [ download sequences in FASTA format ]
C (dna): 
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D (dna): 
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A (protein): 
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B (protein): 
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