General information
PDB ID 3V79
Title STRUCTURE OF HUMAN NOTCH1 TRANSCRIPTION COMPLEX INCLUDING CSL, RAM, ANK, AND MAML-1 ON HES-1 PROMOTER DNA SEQUENCE
PDB header TRANSCRIPTION/DNA
Date 2011-12-20
Experimental method X-RAY DIFFRACTION
Resolution (A) 3.85
Kind dna
Organism HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb3v79.pdb KCMR XY 0
Biounits:
3v79.pdb1.pdb KCMR XY 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
BTD Domain Q06330_206-328 1.5e-61 1 CL0066 C 192 314 X  S-Bb 
LAG1-DNAbind Domain Q06330_48-178 3.5e-47 1 CL0073 C 34 164 XY  L-Bb L-Mj 
TIG_SUH Domain Q06330_354-444 7.5e-32 1 CL0159 C 340 430   
MamL-1 Domain Q92585_16-70 8.2e-27 1 No_clan M 16 70   
Ank_2 Repeat P46531_1971-2058 4.6e-12 1 CL0465 K 2006 2093   
Ank_5 Repeat P46531_1890-1937 2e-10 1 CL0465 K 1920 1967   
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
C=23-449 C cytoplasm
C=23-449 C MAML1-RBP-Jkappa- ICN1 complex
C=23-449 C nuclear chromatin
C=23-449 C nucleolus
C=23-449 C nucleoplasm
C=23-449 C nucleus
C=23-449 C transcription regulator complex
C=23-449 C transcription repressor complex
C=23-449 F chromatin binding
C=23-449 F DNA binding
C=23-449 F DNA-binding transcription activator activity, RNA polymerase II-specific
C=23-449 F DNA-binding transcription factor activity
C=23-449 F DNA-binding transcription factor activity, RNA polymerase II-specific
C=23-449 F protein N-terminus binding
C=23-449 F repressing transcription factor binding
C=23-449 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
C=23-449 F RNA polymerase II repressing transcription factor binding
C=23-449 F sequence-specific DNA binding
C=23-449 F transcription factor binding
C=23-449 P angiogenesis
C=23-449 P aortic valve development
C=23-449 P arterial endothelial cell fate commitment
C=23-449 P atrioventricular canal development
C=23-449 P auditory receptor cell fate commitment
C=23-449 P B cell differentiation
C=23-449 P blood vessel endothelial cell fate specification
C=23-449 P blood vessel lumenization
C=23-449 P blood vessel remodeling
C=23-449 P cardiac left ventricle morphogenesis
C=23-449 P club cell differentiation
C=23-449 P defense response to bacterium
C=23-449 P dorsal aorta morphogenesis
C=23-449 P endocardium morphogenesis
C=23-449 P epidermal cell fate specification
C=23-449 P epithelial to mesenchymal transition
C=23-449 P epithelial to mesenchymal transition involved in endocardial cushion formation
C=23-449 P hair follicle maturation
C=23-449 P humoral immune response
C=23-449 P inflammatory response to antigenic stimulus
C=23-449 P interleukin-4 production
C=23-449 P keratinocyte differentiation
C=23-449 P labyrinthine layer blood vessel development
C=23-449 P myeloid dendritic cell differentiation
C=23-449 P negative regulation of cell differentiation
C=23-449 P negative regulation of cell population proliferation
C=23-449 P negative regulation of cold-induced thermogenesis
C=23-449 P negative regulation of ossification
C=23-449 P negative regulation of transcription by RNA polymerase II
C=23-449 P negative regulation of transcription, DNA-templated
C=23-449 P Notch signaling involved in heart development
C=23-449 P Notch signaling pathway
C=23-449 P outflow tract morphogenesis
C=23-449 P pituitary gland development
C=23-449 P positive regulation of BMP signaling pathway
C=23-449 P positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment
C=23-449 P positive regulation of cardiac muscle cell proliferation
C=23-449 P positive regulation of cell proliferation involved in heart morphogenesis
C=23-449 P positive regulation of ephrin receptor signaling pathway
C=23-449 P positive regulation of ERBB signaling pathway
C=23-449 P positive regulation of gene expression
C=23-449 P positive regulation of Notch signaling pathway
C=23-449 P positive regulation of transcription by RNA polymerase II
C=23-449 P positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
C=23-449 P positive regulation of transcription of Notch receptor target
C=23-449 P pulmonary valve development
C=23-449 P regulation of timing of cell differentiation
C=23-449 P regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
C=23-449 P sebaceous gland development
C=23-449 P secondary heart field specification
C=23-449 P somatic stem cell population maintenance
C=23-449 P somitogenesis
C=23-449 P transcription initiation from RNA polymerase II promoter
C=23-449 P ventricular septum morphogenesis
C=23-449 P ventricular trabecula myocardium morphogenesis
K=1872-2126, R=1759-1777 C acrosomal vesicle
K=1872-2126, R=1759-1777 C adherens junction
K=1872-2126, R=1759-1777 C apical plasma membrane
K=1872-2126, R=1759-1777 C cell surface
K=1872-2126, R=1759-1777 C cytosol
K=1872-2126, R=1759-1777 C endoplasmic reticulum membrane
K=1872-2126, R=1759-1777 C extracellular region
K=1872-2126, R=1759-1777 C Golgi membrane
K=1872-2126, R=1759-1777 C integral component of membrane
K=1872-2126, R=1759-1777 C MAML1-RBP-Jkappa- ICN1 complex
K=1872-2126, R=1759-1777 C nucleoplasm
K=1872-2126, R=1759-1777 C nucleus
K=1872-2126, R=1759-1777 C plasma membrane
K=1872-2126, R=1759-1777 C receptor complex
K=1872-2126, R=1759-1777 F calcium ion binding
K=1872-2126, R=1759-1777 F chromatin DNA binding
K=1872-2126, R=1759-1777 F enzyme binding
K=1872-2126, R=1759-1777 F enzyme inhibitor activity
K=1872-2126, R=1759-1777 F identical protein binding
K=1872-2126, R=1759-1777 F Notch binding
K=1872-2126, R=1759-1777 F sequence-specific DNA binding
K=1872-2126, R=1759-1777 F transcription coactivator activity
K=1872-2126, R=1759-1777 F transmembrane signaling receptor activity
K=1872-2126, R=1759-1777 P animal organ regeneration
K=1872-2126, R=1759-1777 P aortic valve morphogenesis
K=1872-2126, R=1759-1777 P apoptotic process involved in embryonic digit morphogenesis
K=1872-2126, R=1759-1777 P arterial endothelial cell differentiation
K=1872-2126, R=1759-1777 P astrocyte differentiation
K=1872-2126, R=1759-1777 P atrioventricular node development
K=1872-2126, R=1759-1777 P atrioventricular valve morphogenesis
K=1872-2126, R=1759-1777 P auditory receptor cell fate commitment
K=1872-2126, R=1759-1777 P axon guidance
K=1872-2126, R=1759-1777 P branching morphogenesis of an epithelial tube
K=1872-2126, R=1759-1777 P cardiac atrium morphogenesis
K=1872-2126, R=1759-1777 P cardiac chamber formation
K=1872-2126, R=1759-1777 P cardiac epithelial to mesenchymal transition
K=1872-2126, R=1759-1777 P cardiac left ventricle morphogenesis
K=1872-2126, R=1759-1777 P cardiac muscle cell proliferation
K=1872-2126, R=1759-1777 P cardiac muscle tissue morphogenesis
K=1872-2126, R=1759-1777 P cardiac right atrium morphogenesis
K=1872-2126, R=1759-1777 P cardiac right ventricle formation
K=1872-2126, R=1759-1777 P cardiac septum morphogenesis
K=1872-2126, R=1759-1777 P cardiac vascular smooth muscle cell development
K=1872-2126, R=1759-1777 P cardiac ventricle morphogenesis
K=1872-2126, R=1759-1777 P cell cycle arrest
K=1872-2126, R=1759-1777 P cell differentiation in spinal cord
K=1872-2126, R=1759-1777 P cell fate specification
K=1872-2126, R=1759-1777 P cell migration involved in endocardial cushion formation
K=1872-2126, R=1759-1777 P cellular response to follicle-stimulating hormone stimulus
K=1872-2126, R=1759-1777 P cellular response to vascular endothelial growth factor stimulus
K=1872-2126, R=1759-1777 P cilium assembly
K=1872-2126, R=1759-1777 P collecting duct development
K=1872-2126, R=1759-1777 P compartment pattern specification
K=1872-2126, R=1759-1777 P coronary artery morphogenesis
K=1872-2126, R=1759-1777 P coronary sinus valve morphogenesis
K=1872-2126, R=1759-1777 P coronary vein morphogenesis
K=1872-2126, R=1759-1777 P determination of left/right symmetry
K=1872-2126, R=1759-1777 P distal tubule development
K=1872-2126, R=1759-1777 P embryonic hindlimb morphogenesis
K=1872-2126, R=1759-1777 P endocardial cell differentiation
K=1872-2126, R=1759-1777 P endocardial cushion morphogenesis
K=1872-2126, R=1759-1777 P endocardium development
K=1872-2126, R=1759-1777 P endocardium morphogenesis
K=1872-2126, R=1759-1777 P endoderm development
K=1872-2126, R=1759-1777 P epithelial to mesenchymal transition
K=1872-2126, R=1759-1777 P epithelial to mesenchymal transition involved in endocardial cushion formation
K=1872-2126, R=1759-1777 P forebrain development
K=1872-2126, R=1759-1777 P foregut morphogenesis
K=1872-2126, R=1759-1777 P glomerular mesangial cell development
K=1872-2126, R=1759-1777 P growth involved in heart morphogenesis
K=1872-2126, R=1759-1777 P hair follicle morphogenesis
K=1872-2126, R=1759-1777 P heart development
K=1872-2126, R=1759-1777 P heart looping
K=1872-2126, R=1759-1777 P heart trabecula morphogenesis
K=1872-2126, R=1759-1777 P homeostasis of number of cells within a tissue
K=1872-2126, R=1759-1777 P humoral immune response
K=1872-2126, R=1759-1777 P immune response
K=1872-2126, R=1759-1777 P in utero embryonic development
K=1872-2126, R=1759-1777 P inflammatory response to antigenic stimulus
K=1872-2126, R=1759-1777 P interleukin-4 production
K=1872-2126, R=1759-1777 P keratinocyte differentiation
K=1872-2126, R=1759-1777 P left/right axis specification
K=1872-2126, R=1759-1777 P liver development
K=1872-2126, R=1759-1777 P lung development
K=1872-2126, R=1759-1777 P mesenchymal cell development
K=1872-2126, R=1759-1777 P mitral valve formation
K=1872-2126, R=1759-1777 P negative regulation of anoikis
K=1872-2126, R=1759-1777 P negative regulation of biomineral tissue development
K=1872-2126, R=1759-1777 P negative regulation of BMP signaling pathway
K=1872-2126, R=1759-1777 P negative regulation of calcium ion-dependent exocytosis
K=1872-2126, R=1759-1777 P negative regulation of canonical Wnt signaling pathway
K=1872-2126, R=1759-1777 P negative regulation of cardiac muscle hypertrophy
K=1872-2126, R=1759-1777 P negative regulation of catalytic activity
K=1872-2126, R=1759-1777 P negative regulation of cell adhesion molecule production
K=1872-2126, R=1759-1777 P negative regulation of cell migration involved in sprouting angiogenesis
K=1872-2126, R=1759-1777 P negative regulation of cell population proliferation
K=1872-2126, R=1759-1777 P negative regulation of cell proliferation involved in heart valve morphogenesis
K=1872-2126, R=1759-1777 P negative regulation of cell-cell adhesion mediated by cadherin
K=1872-2126, R=1759-1777 P negative regulation of cell-substrate adhesion
K=1872-2126, R=1759-1777 P negative regulation of cold-induced thermogenesis
K=1872-2126, R=1759-1777 P negative regulation of endothelial cell chemotaxis
K=1872-2126, R=1759-1777 P negative regulation of extracellular matrix constituent secretion
K=1872-2126, R=1759-1777 P negative regulation of gene expression
K=1872-2126, R=1759-1777 P negative regulation of glial cell proliferation
K=1872-2126, R=1759-1777 P negative regulation of growth rate
K=1872-2126, R=1759-1777 P negative regulation of inner ear auditory receptor cell differentiation
K=1872-2126, R=1759-1777 P negative regulation of myoblast differentiation
K=1872-2126, R=1759-1777 P negative regulation of myotube differentiation
K=1872-2126, R=1759-1777 P negative regulation of neurogenesis
K=1872-2126, R=1759-1777 P negative regulation of oligodendrocyte differentiation
K=1872-2126, R=1759-1777 P negative regulation of ossification
K=1872-2126, R=1759-1777 P negative regulation of osteoblast differentiation
K=1872-2126, R=1759-1777 P negative regulation of photoreceptor cell differentiation
K=1872-2126, R=1759-1777 P negative regulation of pro-B cell differentiation
K=1872-2126, R=1759-1777 P negative regulation of stem cell differentiation
K=1872-2126, R=1759-1777 P negative regulation of transcription by RNA polymerase II
K=1872-2126, R=1759-1777 P negative regulation of transcription, DNA-templated
K=1872-2126, R=1759-1777 P neural tube development
K=1872-2126, R=1759-1777 P neuronal stem cell population maintenance
K=1872-2126, R=1759-1777 P Notch signaling involved in heart development
K=1872-2126, R=1759-1777 P Notch signaling pathway
K=1872-2126, R=1759-1777 P Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation
K=1872-2126, R=1759-1777 P oligodendrocyte differentiation
K=1872-2126, R=1759-1777 P outflow tract morphogenesis
K=1872-2126, R=1759-1777 P pericardium morphogenesis
K=1872-2126, R=1759-1777 P positive regulation of aorta morphogenesis
K=1872-2126, R=1759-1777 P positive regulation of apoptotic process involved in morphogenesis
K=1872-2126, R=1759-1777 P positive regulation of astrocyte differentiation
K=1872-2126, R=1759-1777 P positive regulation of BMP signaling pathway
K=1872-2126, R=1759-1777 P positive regulation of cardiac epithelial to mesenchymal transition
K=1872-2126, R=1759-1777 P positive regulation of cardiac muscle cell proliferation
K=1872-2126, R=1759-1777 P positive regulation of cell migration
K=1872-2126, R=1759-1777 P positive regulation of cell population proliferation
K=1872-2126, R=1759-1777 P positive regulation of endothelial cell differentiation
K=1872-2126, R=1759-1777 P positive regulation of epithelial cell proliferation
K=1872-2126, R=1759-1777 P positive regulation of ERK1 and ERK2 cascade
K=1872-2126, R=1759-1777 P positive regulation of gene expression
K=1872-2126, R=1759-1777 P positive regulation of keratinocyte differentiation
K=1872-2126, R=1759-1777 P positive regulation of neuroblast proliferation
K=1872-2126, R=1759-1777 P positive regulation of Notch signaling pathway
K=1872-2126, R=1759-1777 P positive regulation of Ras protein signal transduction
K=1872-2126, R=1759-1777 P positive regulation of receptor signaling pathway via JAK-STAT
K=1872-2126, R=1759-1777 P positive regulation of transcription by RNA polymerase II
K=1872-2126, R=1759-1777 P positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
K=1872-2126, R=1759-1777 P positive regulation of transcription of Notch receptor target
K=1872-2126, R=1759-1777 P positive regulation of transcription, DNA-templated
K=1872-2126, R=1759-1777 P positive regulation of viral genome replication
K=1872-2126, R=1759-1777 P prostate gland epithelium morphogenesis
K=1872-2126, R=1759-1777 P pulmonary valve morphogenesis
K=1872-2126, R=1759-1777 P regulation of epithelial cell proliferation involved in prostate gland development
K=1872-2126, R=1759-1777 P regulation of extracellular matrix assembly
K=1872-2126, R=1759-1777 P regulation of somitogenesis
K=1872-2126, R=1759-1777 P regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
K=1872-2126, R=1759-1777 P regulation of transcription, DNA-templated
K=1872-2126, R=1759-1777 P response to corticosteroid
K=1872-2126, R=1759-1777 P response to lipopolysaccharide
K=1872-2126, R=1759-1777 P response to muramyl dipeptide
K=1872-2126, R=1759-1777 P secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
K=1872-2126, R=1759-1777 P skeletal muscle cell differentiation
K=1872-2126, R=1759-1777 P somatic stem cell division
K=1872-2126, R=1759-1777 P spermatogenesis
K=1872-2126, R=1759-1777 P sprouting angiogenesis
K=1872-2126, R=1759-1777 P tissue regeneration
K=1872-2126, R=1759-1777 P transcription initiation from RNA polymerase II promoter
K=1872-2126, R=1759-1777 P tube formation
K=1872-2126, R=1759-1777 P vasculogenesis involved in coronary vascular morphogenesis
K=1872-2126, R=1759-1777 P venous endothelial cell differentiation
K=1872-2126, R=1759-1777 P ventricular septum morphogenesis
K=1872-2126, R=1759-1777 P ventricular trabecula myocardium morphogenesis
M=13-74 C intracellular membrane-bounded organelle
M=13-74 C MAML1-RBP-Jkappa- ICN1 complex
M=13-74 C nuclear speck
M=13-74 C nucleoplasm
M=13-74 C nucleus
M=13-74 F peptide antigen binding
M=13-74 F protein kinase binding
M=13-74 F transcription coactivator activity
M=13-74 P atrioventricular node cell development
M=13-74 P atrioventricular node development
M=13-74 P myoblast differentiation
M=13-74 P Notch signaling pathway
M=13-74 P positive regulation of myotube differentiation
M=13-74 P positive regulation of Notch signaling pathway
M=13-74 P positive regulation of transcription by RNA polymerase II
M=13-74 P positive regulation of transcription of Notch receptor target
M=13-74 P protein phosphorylation
M=13-74 P transcription initiation from RNA polymerase II promoter
Sequences
Download file with secondary structure created by Stride  
3v79.pdb1.pdb:   [ download sequences in FASTA format ]
X (dna): 
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Y (dna): 
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C (protein): 
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K (protein): 
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M (protein): 
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R (protein): 
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