General information
PDB ID 4E68
Title UNPHOSPHORYLATED STAT3B CORE PROTEIN BINDING TO DSDNA
PDB header TRANSCRIPTION/DNA
Date 2012-03-15
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.58
Kind dna
Organism SYNTHETIC, MUS MUSCULUS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb4e68.pdb A B 0
Biounits:
4e68.pdb1.pdb A B 2
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
STAT_bind Domain P42227_325-464 3.1e-39 1 CL0073 A 325 464 B   
SH2 Domain P42227_584-674 8.9e-14 1 CL0541 A 584 674   
STAT_alpha Family P42227_145-313 6.3e-54 1 No_clan A 145 313   
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
A=127-715 C cytoplasm
A=127-715 C cytosol
A=127-715 C glutamatergic synapse
A=127-715 C mitochondrial inner membrane
A=127-715 C mitochondrion
A=127-715 C nuclear chromatin
A=127-715 C nucleoplasm
A=127-715 C nucleus
A=127-715 C plasma membrane
A=127-715 C postsynaptic density
A=127-715 C RNA polymerase II transcription regulator complex
A=127-715 C Schaffer collateral - CA1 synapse
A=127-715 C transcription regulator complex
A=127-715 F CCR5 chemokine receptor binding
A=127-715 F chromatin DNA binding
A=127-715 F DNA binding
A=127-715 F DNA-binding transcription activator activity, RNA polymerase II-specific
A=127-715 F DNA-binding transcription factor activity
A=127-715 F DNA-binding transcription factor activity, RNA polymerase II-specific
A=127-715 F glucocorticoid receptor binding
A=127-715 F identical protein binding
A=127-715 F nuclear receptor activity
A=127-715 F primary miRNA binding
A=127-715 F protein dimerization activity
A=127-715 F protein homodimerization activity
A=127-715 F protein kinase binding
A=127-715 F protein phosphatase binding
A=127-715 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
A=127-715 F RNA polymerase II repressing transcription factor binding
A=127-715 F sequence-specific DNA binding
A=127-715 F transcription factor binding
A=127-715 F transcription regulatory region sequence-specific DNA binding
A=127-715 P acute-phase response
A=127-715 P aging
A=127-715 P astrocyte differentiation
A=127-715 P cell population proliferation
A=127-715 P cellular response to cytokine stimulus
A=127-715 P cellular response to hormone stimulus
A=127-715 P cellular response to leptin stimulus
A=127-715 P cellular response to organic cyclic compound
A=127-715 P cytokine-mediated signaling pathway
A=127-715 P defense response
A=127-715 P eating behavior
A=127-715 P energy homeostasis
A=127-715 P eye photoreceptor cell differentiation
A=127-715 P glucose homeostasis
A=127-715 P growth hormone receptor signaling pathway
A=127-715 P growth hormone receptor signaling pathway via JAK-STAT
A=127-715 P inflammatory response
A=127-715 P interleukin-6-mediated signaling pathway
A=127-715 P intracellular receptor signaling pathway
A=127-715 P leptin-mediated signaling pathway
A=127-715 P modulation of chemical synaptic transmission
A=127-715 P mRNA transcription by RNA polymerase II
A=127-715 P negative regulation of autophagy
A=127-715 P negative regulation of cell death
A=127-715 P negative regulation of cell population proliferation
A=127-715 P negative regulation of glycolytic process
A=127-715 P negative regulation of hydrogen peroxide biosynthetic process
A=127-715 P negative regulation of neuron death
A=127-715 P negative regulation of neuron migration
A=127-715 P negative regulation of primary miRNA processing
A=127-715 P negative regulation of stem cell differentiation
A=127-715 P phosphorylation
A=127-715 P positive regulation of angiogenesis
A=127-715 P positive regulation of ATP biosynthetic process
A=127-715 P positive regulation of cell migration
A=127-715 P positive regulation of cell population proliferation
A=127-715 P positive regulation of cytokine production involved in inflammatory response
A=127-715 P positive regulation of erythrocyte differentiation
A=127-715 P positive regulation of gene expression
A=127-715 P positive regulation of gene silencing by miRNA
A=127-715 P positive regulation of growth factor dependent skeletal muscle satellite cell proliferation
A=127-715 P positive regulation of interleukin-1 beta production
A=127-715 P positive regulation of interleukin-10 production
A=127-715 P positive regulation of interleukin-6 production
A=127-715 P positive regulation of interleukin-8 production
A=127-715 P positive regulation of metalloendopeptidase activity
A=127-715 P positive regulation of miRNA mediated inhibition of translation
A=127-715 P positive regulation of NF-kappaB transcription factor activity
A=127-715 P positive regulation of Notch signaling pathway
A=127-715 P positive regulation of pri-miRNA transcription by RNA polymerase II
A=127-715 P positive regulation of transcription by RNA polymerase II
A=127-715 P positive regulation of transcription, DNA-templated
A=127-715 P positive regulation of tumor necrosis factor biosynthetic process
A=127-715 P positive regulation of tumor necrosis factor secretion
A=127-715 P positive regulation of vascular endothelial cell proliferation
A=127-715 P postsynapse to nucleus signaling pathway
A=127-715 P protein import into nucleus
A=127-715 P radial glial cell differentiation
A=127-715 P receptor signaling pathway via JAK-STAT
A=127-715 P regulation of cell cycle
A=127-715 P regulation of cell population proliferation
A=127-715 P regulation of feeding behavior
A=127-715 P regulation of mitochondrial membrane permeability
A=127-715 P regulation of multicellular organism growth
A=127-715 P regulation of transcription, DNA-templated
A=127-715 P response to cytokine
A=127-715 P response to drug
A=127-715 P response to estradiol
A=127-715 P response to ethanol
A=127-715 P response to leptin
A=127-715 P response to peptide hormone
A=127-715 P sexual reproduction
A=127-715 P stem cell population maintenance
A=127-715 P T-helper 17 cell lineage commitment
A=127-715 P T-helper 17 type immune response
A=127-715 P temperature homeostasis
A=127-715 P transcription by RNA polymerase II
Sequences
Download file with secondary structure created by Stride  
4e68.pdb1.pdb:   [ download sequences in FASTA format ]
B (dna): 
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A (protein): 
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