General information
PDB ID 4EI3
Title CRYSTAL STRUCTURE OF HUMAN ARGONAUTE2
PDB header HYDROLASE/RNA
Date 2012-04-04
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.89
Kind rna
Organism HOMO SAPIENS
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CATH PDBsum HSSP PDBePISA UniProt
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Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb4ei3.pdb A B 0
Biounits:
4ei3.pdb1.pdb A B 1
Pfam domains
Name: Type: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Action:
ArgoMid Domain 6.4e-33 1 No_clan A 429 511
ArgoN Domain 1.6e-27 1 No_clan A 36 166
PAZ Domain 6.6e-26 1 CL0638 A 231 365 B
ArgoL1 Domain 1.6e-21 1 No_clan A 176 226 B
Piwi Family 2.1e-111 1 CL0219 A 517 818 B
ArgoL2 Family 0.00000000000032 1 No_clan A 374 420
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
A=1-859 C micro-ribonucleoprotein complex
A=1-859 C RNA-induced silencing complex
A=1-859 C cytoplasmic mRNA processing body
A=1-859 C nucleus
A=1-859 C mRNA cap binding complex
A=1-859 C cytosol
A=1-859 C polysome
A=1-859 F siRNA binding
A=1-859 F translation initiation factor activity
A=1-859 F endoribonuclease activity, cleaving siRNA-paired mRNA
A=1-859 F metal ion binding
A=1-859 F RNA 7-methylguanosine cap binding
A=1-859 P transcription, DNA-dependent
A=1-859 P post-embryonic development
A=1-859 P mRNA cleavage involved in gene silencing by miRNA
A=1-859 P Notch signaling pathway
A=1-859 P regulation of transcription, DNA-dependent
A=1-859 P negative regulation of translational initiation
A=1-859 P pre-miRNA processing
A=1-859 P negative regulation of translation involved in gene silencing by miRNA
Sequences
Download file with secondary structure created by Stride  
4ei3.pdb1.pdb:   [ download sequences in FASTA format ]
A (protein): 
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B (rna): 
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