General information
PDB ID 4EUW
Title CRYSTAL STRUCTURE OF A HMG DOMAIN OF TRANSCRIPTION FACTOR SOX-9 BOUND TO DNA (SOX-9/DNA) FROM HOMO SAPIENS AT 2.77 A RESOLUTION
PDB header TRANSCRIPTION/DNA
Date 2012-04-25
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.77
Kind dna
Organism HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb4euw.pdb A BC 0
Biounits:
4euw.pdb1.pdb A BC 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
HMG_box Domain P48436_105-173 2.1e-27 1 CL0114 A 105 173 BC  H-Bb H-Mj H-Mn L-Bb L-Mn 
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
A=98-181 C chromatin remodeling complex
A=98-181 F RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
A=98-181 F enhancer sequence-specific DNA binding
A=98-181 F protein kinase activity
A=98-181 F chromatin binding
A=98-181 F core promoter sequence-specific DNA binding
A=98-181 F RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
A=98-181 P negative regulation of biomineral tissue development
A=98-181 P cellular response to heparin
A=98-181 P negative regulation of transcription, DNA-dependent
A=98-181 P neural crest cell development
A=98-181 P intrahepatic bile duct development
A=98-181 P retinal rod cell differentiation
A=98-181 P positive regulation of branching involved in ureteric bud morphogenesis
A=98-181 P notochord development
A=98-181 P regulation of cell adhesion
A=98-181 P protein kinase B signaling cascade
A=98-181 P extracellular matrix organization
A=98-181 P hair follicle development
A=98-181 P cellular response to mechanical stimulus
A=98-181 P negative regulation of apoptotic process
A=98-181 P metanephric nephron tubule formation
A=98-181 P positive regulation of phosphatidylinositol 3-kinase cascade
A=98-181 P epithelial cell proliferation involved in prostatic bud elongation
A=98-181 P negative regulation of photoreceptor cell differentiation
A=98-181 P positive regulation of chondrocyte differentiation
A=98-181 P epithelial to mesenchymal transition
A=98-181 P cell fate specification
A=98-181 P positive regulation of cell proliferation involved in heart morphogenesis
A=98-181 P negative regulation of ossification
A=98-181 P limb bud formation
A=98-181 P epidermal growth factor receptor signaling pathway
A=98-181 P chromatin remodeling
A=98-181 P cellular response to epidermal growth factor stimulus
A=98-181 P positive regulation of male gonad development
A=98-181 P endocardial cushion morphogenesis
A=98-181 P ureter urothelium development
A=98-181 P negative regulation of myoblast differentiation
A=98-181 P heart valve morphogenesis
A=98-181 P spermatogenesis
A=98-181 P nucleosome assembly
A=98-181 P Sertoli cell differentiation
A=98-181 P somatic stem cell maintenance
A=98-181 P regulation of cell proliferation involved in tissue homeostasis
A=98-181 P ossification
A=98-181 P intestinal epithelial structure maintenance
A=98-181 P positive regulation of protein catabolic process
A=98-181 P male germ-line sex determination
A=98-181 P cellular response to transforming growth factor beta stimulus
A=98-181 P positive regulation of mesenchymal stem cell differentiation
A=98-181 P regulation of cell cycle process
A=98-181 P ureter morphogenesis
A=98-181 P chondrocyte hypertrophy
A=98-181 P protein complex assembly
A=98-181 P positive regulation of cartilage development
A=98-181 P positive regulation of protein phosphorylation
A=98-181 P positive regulation of epithelial cell differentiation
A=98-181 P chondrocyte differentiation involved in endochondral bone morphogenesis
A=98-181 P astrocyte fate commitment
A=98-181 P positive regulation of epithelial cell proliferation
A=98-181 P negative regulation of bone mineralization
A=98-181 P cAMP-mediated signaling
A=98-181 P oligodendrocyte differentiation
A=98-181 P cellular response to retinoic acid
A=98-181 P cartilage condensation
A=98-181 P negative regulation of canonical Wnt receptor signaling pathway
A=98-181 P negative regulation of immune system process
A=98-181 P negative regulation of chondrocyte differentiation
A=98-181 P positive regulation of epithelial cell migration
A=98-181 P branching involved in ureteric bud morphogenesis
A=98-181 P otic vesicle formation
A=98-181 P Sertoli cell development
A=98-181 P renal vesicle induction
A=98-181 P cochlea morphogenesis
A=98-181 P cellular response to interleukin-1
A=98-181 P positive regulation of mesenchymal cell proliferation
A=98-181 P ERK1 and ERK2 cascade
A=98-181 P heart valve formation
A=98-181 P negative regulation of epithelial cell proliferation
A=98-181 P endocrine pancreas development
A=98-181 P mammary gland development
Sequences
Download file with secondary structure created by Stride  
4euw.pdb1.pdb:   [ download sequences in FASTA format ]
B (dna): 
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C (dna): 
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A (protein): 
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