General information
PDB ID 4FM9
Title HUMAN TOPOISOMERASE II ALPHA BOUND TO DNA
PDB header ISOMERASE/DNA
Date 2012-06-15
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.9
Kind dna
Organism HOMO SAPIENS, SYNTHETIC CONSTRUCT
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb4fm9.pdb A CD 0
Biounits:
4fm9.pdb1.pdb AB CDEF 0
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
DNA_topoisoIV Family P11388_713-1172 5e-134 1 No_clan A 713 1172 CDE  H-Mj S-Bb S-Mj S-Mn L-Bb 
TOPRIM_C Family P11388_573-711 6.5e-51 1 No_clan A 573 711 D  H-Bb 
Toprim Family P11388_456-572 0.0000000014 1 CL0413 A 456 572 CDF  H-Bb S-Bb L-Bb L-Mn 
DNA_topoisoIV Family 5e-134 1 No_clan B 713 1172 CEF
TOPRIM_C Family 6.5e-51 1 No_clan B 573 711 F
Toprim Family 0.0000000014 1 CL0413 B 456 572 EFD
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
A=431-1193 C cytoplasm
A=431-1193 C nucleolus
A=431-1193 C DNA topoisomerase complex (ATP-hydrolyzing)
A=431-1193 C nucleoplasm
A=431-1193 C synaptonemal complex
A=431-1193 F structure-specific DNA binding
A=431-1193 F sequence-specific DNA binding
A=431-1193 F drug binding
A=431-1193 F chromatin binding
A=431-1193 F DNA topoisomerase (ATP-hydrolyzing) activity
A=431-1193 F ATP binding
A=431-1193 P positive regulation of retroviral genome replication
A=431-1193 P DNA-dependent DNA replication
A=431-1193 P response to drug
A=431-1193 P embryonic cleavage
A=431-1193 P apoptotic chromosome condensation
A=431-1193 P mitotic cell cycle G2/M transition decatenation checkpoint
A=431-1193 P positive regulation of apoptotic process
A=431-1193 P DNA ligation
A=431-1193 P phosphatidylinositol-mediated signaling
A=431-1193 P response to parathyroid hormone stimulus
A=431-1193 P DNA repair
A=431-1193 P sister chromatid segregation
A=431-1193 P resolution of meiotic recombination intermediates
A=431-1193 P positive regulation of transcription from RNA polymerase II promoter
A=431-1193 P aging
A=431-1193 P DNA topological change
A=431-1193 P mitotic recombination
Sequences
Download file with secondary structure created by Stride  
4fm9.pdb1.pdb:   [ download sequences in FASTA format ]
C (dna): 
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D (dna): 
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E (dna): 
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F (dna): 
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A (protein): 
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B (protein): 
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